Antiviral drugs Flashcards
What class of anti-viral drugs does Enfuvirtide belong to (what does it target)? What is it effective against?
Viral entry
HIV
Against what drugs has the flu gained resistance? What class of anti-viral drugs do these belong to (what do they target)?
Amantadine, Rimantadine
Viral uncoating
What class of anti-viral drugs do Nucleoside analogs, Non-nucleoside polymerase inhibitors, and non-nucleoside reverse transcriptase inhibitors belong to (what do they target)? What are they affective against?
Nucleic acid synthesis
Herpesviruses, HIV
What class of anti-viral drugs is used to treat influenza?
viral uncoating
What class of anti-viral drugs do Protease inhibitors and neuraminidase inhibitors belong to (what do they target)?
Assembly and release of viral particles
What are antiviral drugs which target assembly and release of viral particles effective against?
HIV
What are Protease inhibitors effective against?
Influenza
What are antiviral drugs which target intrinsic immunity effective against?
Hep C, Hep B, and more
What class of anti-viral drugs does Peg-interferon belong to (what does it target)?
intrinsic immunity
What do nucleoside analogs do?
compete for enzymes in purine and pyrimidine synthesis pathways
The Specificity issues with antivirals include:
- Most drugs target functions of _____
- _______ are rare
only one virus
broad spectrum drugs
The Cytotoxicity issues with antivirals include:
- “Off target” effects can ________
- “On target” drugs directed at viral enzymes can be _____________
harm cells
defeated by resistance
The issues with duration of antiviral effects include:
- Most drugs are _______ (______ inhibitors)
- Virus ______ can resume when drug is cleared (_____)
- Treatment might need to be ________
reversible; competitive
replication; rebound
life-long
Antiviral resistance mutations often occur in a patient before/after drug treatment?
before
High rate of virus replication, high mutation rate (higher in RNA than DNA), high selective drug pressure (from long-term or multi drug treatments), and an immunosuppressed host who cannot clear virus infected cells are all factors favoring _________.
emergence of resistant variants
