Fungal medications MOA Exam 1

Question 1

Allylamines & Benzylamine

Answer 1

target the fungal cell membrane; inhibit the enzyme squalene epoxidase (squalene monooxygenase), thereby inhibiting ergosterol synthesis. Ergosterol is a key component of the cell membrane in many fungal organisms

Question 2

Azoles

Answer 2

target the fungal cell membrane; disrupts fungal cell mitotic spindle, thereby halting fungal cell division;
inhibits lanosterol from being converted to ergosterol

Question 3

Polyenes

Answer 3

target the fungal cell membrane; bind ergosterol in the fungal cell membrane causing pore formation that leads to increased membrane permeability and rapid cell death

Question 4

Amphotericin B

Answer 4

Bind to ergosterol and make a hole in the cell membrane

Question 5

Nystatin

Answer 5

Bind to ergosterol and make a hole in the cell membrane

Question 6

Griseofulvin

Answer 6

Inhibits fungal cell division

Question 7

Flucytosine

Answer 7

Inhibits DNA and RNA synthesis

Question 8

Terbinafine

Answer 8

Inhibits squalene to being converted to squalene epoxide

Question 9

Echinocandins

Answer 9

Inhibits beta glycan synthase (beta glycan needed for cell wall)