Fungal Infections of the Respiratory Tract I Flashcards

1
Q

Zygomycoses

A

group of uncommon, but potentially fatal infection. infection is rare in normal healthy people

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2
Q

How can you identify zygomycoses

A

non-septate hyphae

sporangia bearing sporangiospores

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3
Q

Symptoms of rhinocerebral zygomycosis

A

nasal congestion, blood tinged rhinorrhea, tender sinuses, headache and fever

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4
Q

What can rhinocerebral zygomycosis progress to

A

facial or periorital edema and visual disturbances, can even get to coma and death

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5
Q

How do you treat zygomycoses?

A

amphotericin B

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6
Q

When is candida in yeast form

A

when it’s normal flora

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7
Q

When is candida in hyphal form

A

when it’s in tissue

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8
Q

Symptoms of oral candidiasis

A

diffuse erythema and white patches on surface of buccal mucosa, throat, tongue and gums
white lesions

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9
Q

How do you treat oral candidiasis

A

oral formations of nystatin and azole

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10
Q

Systemic myocses

A

diverse group of clinical presentations
not opportunity
acquired by inhibition of fungal elements

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11
Q

What do clinical syndromes of systemic mycoeses start as

A

pulmonary infection

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12
Q

What are the systemic mycoses

A

histoplasma capsulatum
blastomyces dermatititdis
paracoccidiodides brasiliensis
coccidiodies immitis

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13
Q

Are systemic mycoses dimorphic?

A

yes

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14
Q

Where is histoplasmosis endemic

A

mississippi and ohio river valleys

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15
Q

What is histoplasmosis associated with

A

bird and bat droppings

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16
Q

How is histoplasmosis transmitted

A

inhalation

17
Q

What happens in your body when it’s infected with histoplasmosis

A

inhaled sproes are phagocytosed by pulmonary macrophages and convert to yeast form. Yeast replicates within macrophages

18
Q

Symptoms of pulmonary histoplasmosis

A

mild flu like illness

not a lot of sputum production

19
Q

What is the treatment of pulmonary histoplasmosis

A

most people don’t need intervention

20
Q

Chronic Pulmonary and Disseminated Histoplasmosis symptoms

A

similiar to TB but with heptomegaly, splenomegaly, and lymphadenopathy

21
Q

How do you treat chronic pulmonary and disseminated histoplasmosis

A

Amphotericin B

22
Q

How do you treat someone with chronic pulmonary and disseminated histoplasmosis AND AIDS

A

lifelong suppressive therapy with azoles

23
Q

Blastomycosis

A

endemic in ohio and missippi river valley

exists in moist soil high in decaying vegetation content

24
Q

How does blastomyces exist in environment

A

mold

25
Q

How does blastomyces exist in tissue

A

yeast

26
Q

How can you tell blastomyces from histoplasma in yeast form

A

blastomyces has a larger size and very thick cell walls

27
Q

symptoms acute blastomycosis

A

cough, fever, chills, arthralgia, myalgia

28
Q

symptoms of chronic pulmonary blastomycosis

A

cough, fever, night sweats, weight loss, sputum

29
Q

Symptoms of disseminated disease of blastomycosis

A

skin, bone, and urogenital lesions

30
Q

What is the treatment of blastomycosis

A

amphotericin B