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Micro Exam II > Bacterial Infections of the Lower Respiratory Tract II > Flashcards

Bacterial Infections of the Lower Respiratory Tract II Flashcards

1
Q

What is the most common cause of walking pneumonia

A

mycoplasma pneumoniae

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2
Q

What is the most common cause of toxic pneumonia

A

legionella pneumophila

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3
Q

Treatment for atypical pneumonia

A

tetracycline and erythromycin

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4
Q

Characteristics of mycoplasma pneumoniae

A

no peptidoglycan
membrane contains sterols
fried egg colony morpholy
restricted to humans

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5
Q

How is mycoplasma pneumoniae spread

A

respiratory droplets

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6
Q

Virulence factor of mycoplasma pneumoniae

A

P1 adhesion

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7
Q

How does P1 adhesion work

A

binds to base of cilia, causes epithelial cell damage/death, and defect in mucociliary clearance

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8
Q

How do you confirm mycoplasma pneumoniae with lab tests

A

PCR, EIA

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9
Q

How do prevent mycoplasma pneumoniae disease

A

no vaccine

avoid overcrowded areas

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10
Q

Characteristics of chylamydophila pneumoniae

A

small, gram neg

obilgate intercellular pathogen

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11
Q

How can you confirm chylamdophilia pneumoniae with lab tests

A

microimmuofluorescence

PCR

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12
Q

What disease does chylamydophila pneumoniae cause

A

atypical (walking) pneumonia

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13
Q

Characteristics of legionella pneumophilia

A

gram negative
inside cells - coccobacilli
outside of cell -pleomorphic

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14
Q

Where is legionella pneumophila often found

A

freshwater lakes, streams, groud water, mud, riverbanks

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15
Q

What does legionella pneumophilia mainly exist as

A

parasites of amoeba

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16
Q

How does legionella pneumonphila get spread to humans

A

cooling towers/AC
respiratory therapy devices
the misting at the grocery stores

17
Q

Virulence of legionella pneumophilia

A

target and attach to alveolar macrophage using pili, flagella, numerous proteins

18
Q

Pathogenesis of legionella pneumophilia

A

prevents fusion with lysosome
makes stuff in the legionella containg vacuole
replicate to high numbers, the cell lyses, and the process starts over again

19
Q

Symptoms of legionarries

A

chills, pleurisy, vomiting, diarrhea, confusion, delirium

elevated WBC count but no left band shift

20
Q

What lab tests can you do to confirm it’s legionella pneumophilia

A

DFA

nucleic acid amplifcation (however with both of these you get a lot of false negs)

21
Q

How do you treat legionella pneumophilia

A

macrolide or fluoroquinolone

22
Q

How do you prevent legionella pneumophilia

A

minimize exposure to/production of contaminated aerosols

Micro Exam II (8 decks)

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