Functions of G coupled receptors Flashcards

1
Q

Can the G protien compelx be stimultaory or inhibitory

A

BOTH

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2
Q

What does Adenyly Cyclase Chlorea Toxin cause

A

Diarrhea

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3
Q

How does Adenyly cyclase cholera toxin create diarrahea

A

It enters the inside where it is able to bind to the G protien sub unit that stimulates Adenylate cyclase which turns on cAMP and turns on protien kinase A which pumps out chlorine creating a salt where water then needs to be pumped out causing diarrhea

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4
Q

What is Pertuss toxin do

A

uses whooping cough in the lungs

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5
Q

What state is the G protien in when pertussis toxin

A

It is in stimulating state because the inactive state is bloced by the PTX toxin so cAMP is always being produced

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6
Q

Where does cAMP bind to PKA first

A

The B cite and then the A cite

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7
Q

What does cAMP binding to the CNB-B site do

A

Creates a higher affinity and a lower kD

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8
Q

What detaches from protien kinase

A

The catalytic site

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9
Q

What are four common intracellular second messengers

A
  1. Cyclic AMP
  2. Cyclic GMP
  3. Diacylglyceron
  4. Inositol trisphoshpate
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10
Q

what does cAMP do

Inglycogen metabolism

A

Activate PKA

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11
Q

What does PKA activate to produce glucose

A

GPK which then produces GP

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12
Q

What is the inhibtor of phosohoprotien phsophates doing when trying to produce glucose

A

It is activated to inhbiot phophoprotien phosphate which are molecules that remove phosphates

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13
Q

What is the stimulatory hormone that activates glucose production

A

epinepherine, glucagon

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14
Q

How do you get glucose back into its glycogen form

A

Remove the stimulatory hormone

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15
Q

What will removing the stimulatory hormone do

A

Activate glycogen synthatse because it is no longer phosphorylated by PKA

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16
Q

What is activating phosphorylation for glucose

A

Glycogen phosphorylase kinase
Glycogen phosphorylase

17
Q

What is inhiitory phosphorylation for production of glucose

A

Inactive of glycogen synthase
And the phoshporylation of the inhibitor of phosphoprotien phosphatase

18
Q

What is active-de phosphorylation of glycogen synthesis

A

GS when it is not phosphorylated it is in its active form

19
Q

What is inactive of glycogen breakdown (inhibiton)

A

GPK and GP is inactive when it is dephoshporylated

20
Q

What is the genes regulated by PKA have a specefic…

A

Nucletoide sequence that is known as cAMP response element

21
Q

What does CREB stand for

A

CRE-binding protien

22
Q

How does P-CREB bind

A

as a dimer to cAMP response element

23
Q

What does P-CREB also bind too

A

CBP/P300 coactivator

24
Q

what does CBP/P300 do

A

Recruits transcriptional machinery

25
What plays a major role for synaptic remodeling
CREB
26
What does Phospholipase C do
Cleaves PIP2 into DAG and IP3
27
What activates PLC
Certain Ga subunits
28
When does Phosphilpase cleave
When it is bound to the GTP alpha G subunit
29
What does IP3 do when released
Opens the Ca channel into the ER
30
What does calcium do when it is the ER
Attach to the protein kinase which then turns on phosphorylation of substrates
31
What does Nitroglycerin be used to treat
Angina it decomposes into NO
32
How does relaxation of muscle cell occur
Acetylechloine is relased which activates GPCR then Phosphlipase C then the IP3 activated the Calcium which creates NO sunthase producing NO onto the receptor creating cGMP then protien kinase G which will have the muscle relax
33
Who uses vigra mostly
Older people because there blood pressure is higher
34
How does Vigra work
It works to inhibit the PDE 5 which in turn converts cGMP into GMP this way it stays at cGMP and produces Protien kinase G and relax the muslce
35
What are side effects of vigra
Priapism (Erection that doesn't go away to O2 to the penis) Heart attack Stroke Sudden Hearing Loss Cynaopsia Decreasing the BP could lead to stroke