From questions Flashcards
Improvement or no improvement in hypoxemia test in cyanotic heart disease
no
Improvement or no improvement in hypoxemia test in meconium aspiration syndrome
yes
Improvement or no improvement in hypoxemia test in persistent pulmonary hypertension
yes
Improvement or no improvement in hypoxemia test in pneumonia
yes
Improvement or no improvement in hypoxemia test in retained fetal lung liquid
yes
Causes of superior vena cava syndrome
1) Extrinsic compression - mediastinal mass or tumor
2) Intrinsic compression - surgical anastomotic sites, baffle stenosis, thrombosis, cardiac tumors
3) Increased right atrial pressure
Pattern: infant 4 weeks of age, fatigues with feeding and now takes twice as long to complete his feeding as he did 1 week ago. Also breathes fast during his feedings and stops frequently to “catch his breath”
congestive heart failure
Regurgitation of mitral valve produces what murmur
holosystolic
Regurgitation of aortic valve produces what murmur
diastolic
Most common two organisms for infective endocarditis
Viridans streptococci
Staphylococcus aureus
If patient with suspected infectious endocarditis is looks acutely ill how do you manage?
Get blood culture than treat with abx
If patient with suspected infection endocarditis has chronic symptoms how you manage?
Get ECHO to confirm
Infective endocarditis can cause hematuria how?
Through deposition of immune complexes
Cases when microalbuminuria are useful.
Diabetes and HTN
Casesw when 24-hour urine testing for proteinuria helpful?
risk factors for nephrolithiasis/urolithiasis or to screen for catecholamine metabolites in children suspected of neural crest tumors (neuroblastoma or pheochromocytom)
Pattern: AR disorder, chornic tubulointerstitial disease (azotemia, ESRD), polyuria, polydipsia, tubular wasting leading to hyponatremia and salt cravings, acidosis, anemia, azotemia, associated with Senior-Loken syndrome with tapetoretinal degeneration, retinitis pigmentosa
Juvenile nephroopththisis
What are all the eye findings in Senior-Loken?
1) tapetoretinal degneration, retinitis pigmentosa, blindness, nystagmus, coloboma, cataracts
Pattern: aplasia of cerebellar vermis causing ataxia and retinal coloboma/retinitis pigmentosa
Joubert
Gene: nephronophthisis
NPHP1 gene, chromosome 2q12.3 (nephrocystin 1) NPHP2 and NPHP3 encode for proteins for infantile and adolescent
Eye finding in Alport
Anterior lenticonus and catarcts
Pattern: X-linked FAnconi (glycosuria, met acid, aminoaciduria, hypophosphatemia) MR, and congenital cataracts
Lowe syndrome
Pattern: AR, Fanconi, FTT, cystine crystal deposition within the cornea, severe photophobia
Nephropathic cystinosis
Any treatment from narrowed urethra in child with h/o of UTI
no, normal variant
What are some extrarenal structural causes for hematuri?
ruptured cyst of cystic kidney (polycystic kidney), renal mass (Wilms tumor), renal stone, renal vein thrombosis, papillary necrosis or hypercalciuria, hemorrhagic cystitis, bladder clculi, hemangioma, rhabdomyosarcoma of the bladder
Definition o hematuria
> 5 RBC/HPF
DDx of red urine
hematuria, hemoglobiunuria, myoglobinuria, porphyrinuria
Dipstick is sensitive to what?
free hemoglobin, myoglobin, intact red blood cells
Definition of persistent microscopic hematuria
blood on UA detected on repeat samples over a 1-month period
Pattern: Fever in setting of UTI in infant and neonates
pyelonephritis
Neonates and infants, UTI no fever
Lower tract
90% of UTIs are caused y what?
E. coli
What is best initial treatment of cystitis?
TMP-SMX
If recurrent UTI, history of resistance or allergy to TMP-SMX, what second line abx?
cephalexin, defixime, or ciprofloxacin
First-linefor steroid-resistant nephrotic?
cyclosporine and then tacrolimus
What is the chance of relapse in minimal change?
50-70%
What are labs associated with hemolysis?
elevated lactate dehydrogenase and low haptoglobin values
What is reticulocytosis sometimes not elevated in HUS?
impaired Epo production
What are two endocrine problems associated with chronic kidney disease?
Increased IGF1 and PTH as compensation
Most common types of renal stones?
calcium oxalate, calcium phosphate, mixd, struvite, cystine, and uric acid
Promoters of kidney stone formation
calcium, oxalate, uric acid, cystine
Inhibitors of stone formation
magnesium and citrate
What first test to do for evaluation of kidney stones
urinary calcium excretion
What organism is associated with struvite stone
proteus, produces urease
Pattern: hypercalciuria and renal stones
RTA
Pattern: midface hypoplasia, ocular hypertelorism, nail hypoplasia, cleft lip +/- cleft palate, and heart defects, developmental delay, pre and postnatal growth failure
Phenobarbital toxicity
Pattern: newborn with cyanosis, hypotonia, abnormalities of cardiac rhythm, goiter, hypothyroidism, and nephrogenic diabetes insipidus, mom has bipolar
Lithium toxicity
Pattern: newborn with tremulousness, increased irritability and abnormal visual response to light stimulus, what did the mother smoke/ingest prenatally
marijuana
LSD and birth defects Y/N?
No
Is there an increase in congenital anomalies wtih metamphetamine?
No
Describe general picture of polycythemia and hyperviscosity.
Lots of organs can be affected. some signs, hypotonia, sleepiness, irritability, hypoglycemia, jaundice, hypocal, plethora, cardiomegaly, increased pulmonary resistance, decreased cardiac output, Nec
Pattern: in newborn, IUGR, jaundice, heptaospelnomegaly, hepatitis, thrombocytopenia with petechiae and purpura, microcephaly, intracerebral calcifications, chorioretinitis, sensorineural hearing loss
CMV
Estimated MAP for new borns
should not be less than gestational age
Pattern: meat impaction, dysphagia
EE
Pattern: heartburn, dysphagia, odynophagia, hoarseness, chronic cough, exacerbation of asthma, apnea and aspiration pneumonia
GER
Difference b/w findings from GER versus EE
GER- ulceration and injury limited to the distal 5cm of esophagus; EE characterized by inflammation of the proximal, middle and distal esophagus with large number of eosinophils seen on biopsy
GI symptoms associated with Down syndrome
Hirschsprung, duodenal atresia
Most commonly injured intra-abdominal organs
liver and spleen
What are complications of long-term H pylori infection?
Gastric and duodenal ulcers, gastric lymphoma, and atrophic gastritis
What is gold standard test for H pylori?
upper GI endoscopy with biopsy of gastric antrum
What are non invasive tests for H pylori?
IgG serology, fecal sample for H pylori antigen, C13 urea breath test
Rx for H pylori
2 antibiotics and PPI
What is follow-up after H pylori treatment?
documentation of eradication, negative fecal antigen studies or endoscopy