From questions Flashcards

1
Q

Improvement or no improvement in hypoxemia test in cyanotic heart disease

A

no

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2
Q

Improvement or no improvement in hypoxemia test in meconium aspiration syndrome

A

yes

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3
Q

Improvement or no improvement in hypoxemia test in persistent pulmonary hypertension

A

yes

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4
Q

Improvement or no improvement in hypoxemia test in pneumonia

A

yes

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5
Q

Improvement or no improvement in hypoxemia test in retained fetal lung liquid

A

yes

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6
Q

Causes of superior vena cava syndrome

A

1) Extrinsic compression - mediastinal mass or tumor
2) Intrinsic compression - surgical anastomotic sites, baffle stenosis, thrombosis, cardiac tumors
3) Increased right atrial pressure

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7
Q

Pattern: infant 4 weeks of age, fatigues with feeding and now takes twice as long to complete his feeding as he did 1 week ago. Also breathes fast during his feedings and stops frequently to “catch his breath”

A

congestive heart failure

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8
Q

Regurgitation of mitral valve produces what murmur

A

holosystolic

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9
Q

Regurgitation of aortic valve produces what murmur

A

diastolic

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10
Q

Most common two organisms for infective endocarditis

A

Viridans streptococci

Staphylococcus aureus

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11
Q

If patient with suspected infectious endocarditis is looks acutely ill how do you manage?

A

Get blood culture than treat with abx

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12
Q

If patient with suspected infection endocarditis has chronic symptoms how you manage?

A

Get ECHO to confirm

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13
Q

Infective endocarditis can cause hematuria how?

A

Through deposition of immune complexes

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14
Q

Cases when microalbuminuria are useful.

A

Diabetes and HTN

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15
Q

Casesw when 24-hour urine testing for proteinuria helpful?

A

risk factors for nephrolithiasis/urolithiasis or to screen for catecholamine metabolites in children suspected of neural crest tumors (neuroblastoma or pheochromocytom)

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16
Q

Pattern: AR disorder, chornic tubulointerstitial disease (azotemia, ESRD), polyuria, polydipsia, tubular wasting leading to hyponatremia and salt cravings, acidosis, anemia, azotemia, associated with Senior-Loken syndrome with tapetoretinal degeneration, retinitis pigmentosa

A

Juvenile nephroopththisis

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17
Q

What are all the eye findings in Senior-Loken?

A

1) tapetoretinal degneration, retinitis pigmentosa, blindness, nystagmus, coloboma, cataracts

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18
Q

Pattern: aplasia of cerebellar vermis causing ataxia and retinal coloboma/retinitis pigmentosa

A

Joubert

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19
Q

Gene: nephronophthisis

A

NPHP1 gene, chromosome 2q12.3 (nephrocystin 1) NPHP2 and NPHP3 encode for proteins for infantile and adolescent

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20
Q

Eye finding in Alport

A

Anterior lenticonus and catarcts

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21
Q

Pattern: X-linked FAnconi (glycosuria, met acid, aminoaciduria, hypophosphatemia) MR, and congenital cataracts

A

Lowe syndrome

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22
Q

Pattern: AR, Fanconi, FTT, cystine crystal deposition within the cornea, severe photophobia

A

Nephropathic cystinosis

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23
Q

Any treatment from narrowed urethra in child with h/o of UTI

A

no, normal variant

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24
Q

What are some extrarenal structural causes for hematuri?

A

ruptured cyst of cystic kidney (polycystic kidney), renal mass (Wilms tumor), renal stone, renal vein thrombosis, papillary necrosis or hypercalciuria, hemorrhagic cystitis, bladder clculi, hemangioma, rhabdomyosarcoma of the bladder

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25
Q

Definition o hematuria

A

> 5 RBC/HPF

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26
Q

DDx of red urine

A

hematuria, hemoglobiunuria, myoglobinuria, porphyrinuria

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27
Q

Dipstick is sensitive to what?

A

free hemoglobin, myoglobin, intact red blood cells

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28
Q

Definition of persistent microscopic hematuria

A

blood on UA detected on repeat samples over a 1-month period

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29
Q

Pattern: Fever in setting of UTI in infant and neonates

A

pyelonephritis

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30
Q

Neonates and infants, UTI no fever

A

Lower tract

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31
Q

90% of UTIs are caused y what?

A

E. coli

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32
Q

What is best initial treatment of cystitis?

A

TMP-SMX

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33
Q

If recurrent UTI, history of resistance or allergy to TMP-SMX, what second line abx?

A

cephalexin, defixime, or ciprofloxacin

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34
Q

First-linefor steroid-resistant nephrotic?

A

cyclosporine and then tacrolimus

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35
Q

What is the chance of relapse in minimal change?

A

50-70%

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36
Q

What are labs associated with hemolysis?

A

elevated lactate dehydrogenase and low haptoglobin values

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37
Q

What is reticulocytosis sometimes not elevated in HUS?

A

impaired Epo production

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38
Q

What are two endocrine problems associated with chronic kidney disease?

A

Increased IGF1 and PTH as compensation

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39
Q

Most common types of renal stones?

A

calcium oxalate, calcium phosphate, mixd, struvite, cystine, and uric acid

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40
Q

Promoters of kidney stone formation

A

calcium, oxalate, uric acid, cystine

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41
Q

Inhibitors of stone formation

A

magnesium and citrate

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42
Q

What first test to do for evaluation of kidney stones

A

urinary calcium excretion

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43
Q

What organism is associated with struvite stone

A

proteus, produces urease

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44
Q

Pattern: hypercalciuria and renal stones

A

RTA

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45
Q

Pattern: midface hypoplasia, ocular hypertelorism, nail hypoplasia, cleft lip +/- cleft palate, and heart defects, developmental delay, pre and postnatal growth failure

A

Phenobarbital toxicity

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46
Q

Pattern: newborn with cyanosis, hypotonia, abnormalities of cardiac rhythm, goiter, hypothyroidism, and nephrogenic diabetes insipidus, mom has bipolar

A

Lithium toxicity

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47
Q

Pattern: newborn with tremulousness, increased irritability and abnormal visual response to light stimulus, what did the mother smoke/ingest prenatally

A

marijuana

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48
Q

LSD and birth defects Y/N?

A

No

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49
Q

Is there an increase in congenital anomalies wtih metamphetamine?

A

No

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50
Q

Describe general picture of polycythemia and hyperviscosity.

A

Lots of organs can be affected. some signs, hypotonia, sleepiness, irritability, hypoglycemia, jaundice, hypocal, plethora, cardiomegaly, increased pulmonary resistance, decreased cardiac output, Nec

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51
Q

Pattern: in newborn, IUGR, jaundice, heptaospelnomegaly, hepatitis, thrombocytopenia with petechiae and purpura, microcephaly, intracerebral calcifications, chorioretinitis, sensorineural hearing loss

A

CMV

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52
Q

Estimated MAP for new borns

A

should not be less than gestational age

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53
Q

Pattern: meat impaction, dysphagia

A

EE

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54
Q

Pattern: heartburn, dysphagia, odynophagia, hoarseness, chronic cough, exacerbation of asthma, apnea and aspiration pneumonia

A

GER

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55
Q

Difference b/w findings from GER versus EE

A

GER- ulceration and injury limited to the distal 5cm of esophagus; EE characterized by inflammation of the proximal, middle and distal esophagus with large number of eosinophils seen on biopsy

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56
Q

GI symptoms associated with Down syndrome

A

Hirschsprung, duodenal atresia

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57
Q

Most commonly injured intra-abdominal organs

A

liver and spleen

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58
Q

What are complications of long-term H pylori infection?

A

Gastric and duodenal ulcers, gastric lymphoma, and atrophic gastritis

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59
Q

What is gold standard test for H pylori?

A

upper GI endoscopy with biopsy of gastric antrum

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60
Q

What are non invasive tests for H pylori?

A

IgG serology, fecal sample for H pylori antigen, C13 urea breath test

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61
Q

Rx for H pylori

A

2 antibiotics and PPI

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62
Q

What is follow-up after H pylori treatment?

A

documentation of eradication, negative fecal antigen studies or endoscopy

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63
Q

What is the ratio of L:S typically achieved by 35 weeks’ gestation

A

2

64
Q

Is PG or PI used as indicator of pulmonary surfactant maturity?

A

PG

65
Q

What should be used as test for fetal lung maturity in setting of maternal diabetes?

A

surfactant

66
Q

Pattern: bilateral microtia, depressed nasal bridge, ocular hypertelorism, cleft palate, macrocephaly, truncus arteriosus, dilated ventricles with hydrocephalus

A

isotretinon

67
Q

Pattern: neonate with IUGR, ocular hypertelorism, midface hypoplasia, celft lip+/- cleft palate and heart defects

A

phenobarbital and phenytoin

68
Q

Shortened AP dimension. Which suture close early?

A

Coronal

69
Q

Pattern: coronal suture synostosis, large thumbs or great toes

A

FGFR dominant mutation

70
Q

Trigonocephaly “keel-shaped” skull. Which suture close early?

A

metopic

71
Q

Scaphocephalic (long in AP dimension and narrow in biparietal dimension) Which suture close early?

A

sagittal

72
Q

Posterior plagiocephaly (flattening of one or both sides of the occiput) Which suture close early?

A

lambdoid suture

73
Q

When should you start helmet for positional plagiocephaly?

A

9 months

74
Q

When infant sees a mirror, smiles and vocalizes

A

4 mo

75
Q

When infant sees a mirror, reaches for it and pats the image

A

6 mo

76
Q

When infant sees a mirror, offers it a toy

A

12mo

77
Q

Letter reversal is normal up to what age?

A

7yrs

78
Q

Why is MCT used in children with distal ileal resection for nec?

A

It can be absorbed directly across the tnerocyte and does not require intraluminal digestion by bile acids.
LCFA require bile acids for digestion and might cause diarrhea in a child with cholestasis and ileal resection

79
Q

Pattern: cardiac disease (PS), vertebral anomalies, ocular anomalies (posterior embryotoxon), facial dysmorphism (triangular facies, macrocephaly, large ears) and paucity of the intrahepatic bile ducts

A

Alagille syndrome

80
Q

Vitamin deficiency: hypotonia and apnea

A

Magnesium

81
Q

Vitamin deficiency: hypotonia and seizures

A

Vitamin B6

82
Q

Vitamin deficiency: hypotonia, DD, seizures, steely hair

A

Cooper

83
Q

Vitamin deficiency: pallor, poor feeding, hypochromic anemia, neutropenia, and skeletal changes Metaphyseal fraying and osteoporosis

A

Cooper

84
Q

Vitamin deficiency: hemolysis and peripheral neuropathy, hyporeflexia, tremors

A

Vit E

85
Q

Differential for children with small hands and feet, hypogonadism, learning disabilities, MR

A

Prader-Willi and Bardet-Biedl syndromes

86
Q

What infections is absolute contraindication for breast feeding?

A

HIV, untreated TB, active herpes lesion

87
Q

What maternal medications preclude breastfeeding?

A

Chemo, immunosuppressants, lithium and readiopharmaceutical

88
Q

Is candida contraI for breastfeeding?

A

No, but mother and baby should be treated

89
Q

Difference between foodborne and infant botulism

A

Foodborne ingestion of food that is contaminated with spores - honey
Infant results from ingestion of C bot spores that germinat and produce the toxin

90
Q

Pattern: nausea, dry mouth and diarrhea –> cranial nerve dysfunction, most commonly diplopia, blurry vision, descending to include dysphagia, upper extremity weakness, respiratory dysfunction, and lower extremity weakness

A

Foodborne botulism - hours incubation time

91
Q

Pattern: Injury 4 to 14 days prior to symptoms of cranial nerve dysfunction, diplopia, blurry vision, descending to include dysphagia, upper extremity weakness, respiratory dysfunction and lower extremity

A

Wound botulism

92
Q

Pattern: 3 to 30 days from ingestion of spores, constipation, feeding difficulties, hypotonia, incrased drooling, weak cry, diminished gag reflex, truncal weakness, cranial nerve palsies, and generalized weakness

A

Infant botulism

93
Q

Toxin type for infant and wound botulism

A

A and B

94
Q

Rx for wound and foodborne

A

Equine trivalent antitoxin

95
Q

Rx for infant botulism

A

BIGIV

96
Q

Pattern: paralysis ascending beginning in the lower extremities and ascending symmetrically to involve trunk, upper extremities and head within a few hours

A

tick paralysis

97
Q

Three infections that cause oculoglandular disease

A

Bartonella, tularemia, H influ

98
Q

Pattern: fever, diarrhea, blood mucous, neutrophils in stool, seizures

A

Shigella

99
Q

Pattern: tenosynovitis, dermatitis, polyarthralgias

A

Dissemniated gonococcal infection

100
Q

What can cause disseminated syndrome, neonatal conjunctivitis, urethritis, salpingitis, PID

A

N. gonorrhoeae

101
Q

Complications associated with varicella

A

superinfection of skin lesions, pneumonia, cerebellar ataxia, encephalitis, thrombocytopenia, glomerulonephritis, arthritis, and hepatitis

102
Q

Rx for immunocompetent hosts at increased risk for moderate to severe varicella

A

oral acyclovir

103
Q

Persons at increased risk for moderate to severe varicella

A

?12yo, chornic cutaneous or pulm disorders, persons receiving long-term salicylate therapy, people receiving short, intermittent or aerosolized courses of croticosteroids and secondary household cases

104
Q

Rx for immunocompromised patients who have varicellas and who have been treated with chronic corticosteroids

A

IV antiviral

105
Q

Rx for varicella in HIV with normal CD4, leukemic patient in whom careful follow-up is guaranteed

A

High dose oral

106
Q

Which antibiotics should you not take with dairy products?

A

tetracycline, doxycycline, ciprofloxacin

107
Q

Which antibiotics should you not take with food?

A

ampicillin - acid ability

108
Q

Which antibiotics should you take with food to reduce stomach upset?

A

erythromycin and metronidazole

109
Q

Liquid restrictions pre-sedation

A

Milk or food 6 hours
Human milk 4 hours
Clear juices 2 hours

110
Q

Treatment for HSV

A

400mg acyclovir 3x/day for 7 to 10 days

111
Q

After antihistamine, what is next therapy for allergic rhinitis

A

intranasal corticosteroid

112
Q

What % of COHgb concentration is indicative of exposure

A

> 3 to 5% sometimes 100%

113
Q

Rx for carbon monoxide poisoning

A

100% nonrebreather decreases half life from 300 minutes to 90 minutes and should be continued until COHgb concentration is less than 5%

114
Q

When should you suspect bacterial cause of rhinitis?

A

URI persisting longer than 7 to 10 days

115
Q

Most common cause?

A

H influ

116
Q

Rx for acute bacterial rhinosinusitis

A

high dose amoxicillin, augmentin, cefdinir, defpodoxime proxetil, cefuroxime axetil

117
Q

List complications of chronic renal failure

A
  1. poor appetites
  2. impaired growth –> FTT, short stature
  3. Increased IGF-BP so bioavailability of IGF is lower
  4. Decreased urine output with impaired excretion of sodium and water
  5. Hypertension
  6. P, K, Mg accumulate
  7. 25-hydroxyVitD3 exiting liver cannot be activated to 1,25-dihydroxyD3 because of low 1-alpha hydroxylase activity
  8. Low bioactive forms of VitD3 acompanied by phosphorus retention and secondary hyperPTH lead to renal astodystrophy (renal rickets)
  9. Anemia
118
Q

Pattern: dry mucous membrane, can be aroused, dry mucous membranes, and pupillary constriction

A

clonidine overdose

119
Q

In 1/3 to 1/2 of males with Hemophilia A, no family history, what percentage of those mothers could be carriers

A

80%, she could have denovo or germline mosaicism

120
Q

Exercise limitations for mild aortic stenosis and moderate

A

Mild- no restrictions

Moderate - self-limited aerobic activities and avoid isometric activities

121
Q

Drugs that cause hemolysis with G6PD

A

Sulfonamides, antimalarials, aspirin, vit K analogs

122
Q

Rx for corneal abrasion

A

oral pain killers

123
Q

When to refer to ophthalmology after corneal abrasion

A

if complete healing isn’t seen in 2 to 3 days

124
Q

Rx for sulfonylurea overdoses

A

octreotide

125
Q

Pattern: salivation, lacrimation, urination, diarrhea, and gastic emesis

A

cholinergic poisoning via inhibition of acetylcholinesterase inhibitor

126
Q

Pattern: failure to gain weight, jaundice, and hepatomegaly and elevated urine reducing substances

A

galactosemia

127
Q

Adult complications of galactosemia

A

learning disabilities, verbal dyspraxia, neurologic disorders and ovarian failure

128
Q

Name pro-epileptic drugs

A

isoniazid, theophylline, cocaine, burproprion, insulin, cyclosporine

129
Q

HOCM genetics

A

AD

130
Q

Pattern: 16yo boy with family with HCM. Treatment/consult

A

Cardiology should follow

131
Q

How long does oral iron have to be taken for in anemic patient?

A

2 months to replenish iron stores

132
Q

Pattern: bump on neck located laterally along the anterior border of SCM, nonmobile

A

Branchial cleft cysts

133
Q

Pattern: soft midline neck mass that moves vertically when the child swallows or protrudes the tongue, drainage onto the skin

A

Thyroglossal duct cyst

134
Q

What is a cystic hygroma

A

lymphangioma, a soft mass of dilated lymph vessels

135
Q

Pattern: on xray, patchy area of diffuse atelectasis, focal areas of air-trapping, and increased lung volume

A

Meconium stained amniotic fluid

136
Q

Pattern: on xray, air bronchograms, diffusely hazy lung fields, and low lung volume

A

surfactant deficiency-related respiratory distress syndrome

137
Q

Pattern: Diaphoresis, tachycardia, tremulousness, pallor irritability, somnolence, and coma

A

hypoglycemia

138
Q

What are some poisons that cause hypoglycemia

A

oral hypoglycemic agents, insulin, beta-blockers, saicylates, and ethanol

139
Q

What is the RAST method

A

radioallergosorbent test to measure IgE

140
Q

What needs to be discontinued before skin testing

A

Anti-histamine 1 week prior to skin testing

141
Q

Can you anaphylax during skin testing?

A

Yes

142
Q

First-line medication for steroid-resistant nephrotic syndrome

A

cyclosporine

143
Q

Age when most kids are toilet trained

A

98% by 3 years

144
Q

Pleural liquic concentration of protein and LDH for transudate and exudate

A

Transudate protein <3g/dL

LDH <200 IU/L

145
Q

Which metabolic problem can lead to E. coli sepsis

A

galactosemia

146
Q

Iron deficiency can lead to what?

A

impaired cognitive abilities

147
Q

Name the types of fractures that are concerning for NAT

A

metaphyseal chip fractures, metaphyseal bucket handle fractures, fracture of posterior ribs, scapula, spinous process, sternum, multiple fractures, fractures of different ages, femor fractures younger than 1 year of age, complex skull fractures

148
Q

When would you need to use antivenom in spider bite?

A

Indicated only when autonomic symptoms or pain cannot be managed with usual measures

149
Q

Pattern: severe muscular cramping, tremors and autonomic symptoms such as drooling and sweating

A

similar to cholinergic crisis, but can be black widow spider bites

150
Q

Congenital scoliosis is associated with abnormalities in what other organs?

A

Heart, kidneys and spinal cord

151
Q

Management for child with congenital scoliosis

A

serial PA and lateral spine radiographs at birth; after 1 year, spine xray should be taken with child standing and the pelvis maintained in a level position, CT with thin slices and 3D reconstruction may be helpful,especially if malformations are multiple or complex; MRI with cratilate is recommended to determine growth potential

152
Q

Which salter should you reduce and which to cast to immobilize?

A

Reduce Salter III and IV; cast and immobilize V

153
Q

Which Salter sets you up for significant risk for deformity

A

Salter IV and V

154
Q

Endocrine causes of myositis

A

hypo/hyperTH, hypercortisolism, hypo/hyperPTH, hypoca/hypoK

155
Q

Drugs that cause myositis

A

colchicine, lipid-lowering, cyclosporine

156
Q

Metabolic conditions that cause myositis

A

myhosphorylase deficiency, acid maltase deficiency, lipid storage disease