Forensics 1 Flashcards
what is toxicology
analysis of body fluids and tissues for presences of drugs and poisons
3 areas of forensic toxicology
postmortem: cause of death
human performance: drugs/poisons modifying human behaviour or performance
forensic drug testing: determine drug use
knowledge required for a forensic toxicologist
drug metabolism
effects of poisoning on body
analytical chemistry
pharmacological action s
toxicology role in death
homicide suicide accident natural was there a drug, how much, when
does toxicologist determine cause of death
no pathologist does
answers if the amount was sufficient to cause death
info required to aid in interpretation in death
time and date of death details of last meal treated in hospital med history symptoms evidence at scene time delay between death and autopsy
what is postmortem redistribution
distribution of drugs from heart tssue to the cardiac blood
cardiac blood may be significantly elevated which may be good for preliminary investigations
changes start in 1h and usually done in 24hr
more accurate blood level sites
femoral and cardiac may allow for more accurate interpretation of blood level at time of death
some drugs that undergo postmortem redistribution
TCA
digoxin
info to aid interpretation in living person
signs and symptoms
admission of drug or alcohol use
evidence found at scene
4 stages of tox exam
- screen - for as many drugs as possble with as little samples as possible
confirm - 2 aliquots with different tests need to match
quantification - need to use blood, liver, stomach
interpret - toxic, therapeutic, lethal
improper specimen selection, collection, and submission =
inaccurate results
how to ensure continuity of exhibits
labelled by each possesser sent by courier adhesive tape to seal container kept under lock and key no access to lab to anyone unauthorized transfer slips used
types of blood samples and what they contain
serum
plasma - clotting factors
whole blood - RBC need to detect CO poisoning
most reliable sample for alcohol and drug impairment
blood
what is sodium fluoride
preservative to prevent breakdown of some drugs
benefits of urine sample
non invasive
little to no sample prep
drugs/alcohol found in higher concentrations here
longer detection periods
what is meant by urine having a long detection period
drug concentration that is detectable will be in the urine much longer than in the blood
disadvantages of urine
may not reflect level of impairment at time of incident - not quantitative
some drugs break down in body so detection difficult
subject to tampering