Drugs of abuse

Question 1

sources of cocaine

Answer 1

mostly as HCl salt

crack - free base form not water soluble

Question 2

methods of cocaine ingestion

Answer 2

IV
smoking - crack
snorting
oral rare due to first pass effect
topically 
free basing - make HCl into crack

Question 3

desired cocaine effects

Answer 3

intense euphoria
decreased anxiety and social inhibtions
increased alertness, mental clarity, performance in simple tasks, self confidence

Question 4

onset of cocaine effect

Answer 4

7sec smoking

10min oral

Question 5

duration of cocaine effects

Answer 5

20min smoking
60min oral
90min snorting

Question 6

high dose chronic cocaine use effects

Answer 6

dysphoria
fatigue 
confusion
hallucinations
fear and paranoria
aggressiveness
itching of skin 
psychosis

Question 7

what is formucation

Answer 7

sensaton of bugs under skin

Question 8

3 phases of cocaine withdrawal

Answer 8

crash phase: agitation, depression, intense cravings, fatigue lasts 4 days
withdrawal phase: increased anxiety, lack of energy, variable cravings lasts up to 10weeks
extinction phase: episodic cravings for the drug

Question 9

symptoms of cocaine induced excited delirium

Answer 9

dissociative state
violence
exaggerated strength
increased BP
cardiorespiratory arrest
rhabdomyolysis
sudden death

Question 10

type of dependences developed from cocaine use

Answer 10

tolerance
psychological
physiological

Question 11

challenges interpretating cocaine use

Answer 11

enzymes in the blood cause a loss of cociaine

alcohol + cocaine makes cocaethylene metabolite

Question 12

sources of meth

Answer 12

super labs that use bulk quantities of the required substances
small clandestine labs in NA

Question 13

meth is made from

Answer 13

pseudoephedrine or ephedrine
paint thinner
drain cleaner
starter fluid etc

Question 14

how did mb pharmacists try control meth production

Answer 14

max pseudoephedrine sold at one time 3600mg

Question 15

3 methods of meth production

Answer 15

P2P
ephedrine or pseudoephedrine reduction
nazi methods

Question 16

methods of meth ingestion

Answer 16

smoked
snorted
injected
swallowed

Question 17

desired meth effects

Answer 17

euphoria

increased alertness, mental clarity, sense of well being, energy, confidence

Question 18

meth onset

Answer 18

within seconds if smoked or injected

Question 19

duraiton of meth

Answer 19

4-12hr

Question 20

undesired meth effects

Answer 20

meth mouth 
smelly
crank bugs 
tremor 
insomnia
irritable 
hyperthermia
mental confusion

Question 21

after meth effects

Answer 21

extreme fatigue leading to prolonged and disturbed sleep

can lead to depression

Question 22

types of meth dependence

Answer 22

tolerance develops quickly

psychological and physiological

Question 23

interpretation challenges

Answer 23

there are 2 isomers possible have to do another step to identify
d isomer for active addictive and toxic
l isomer in vicks vapour rubs

Question 24

sources of mdma

Answer 24

illicit production only

Question 25

methods of mdma ingestion

Answer 25

oral snorted smoked injection rare

Question 26

desired efffects of mdma

Answer 26

``` euphoria increased sense of well being, energy, self confidence intensification of feelings overwhelming desire to communicate profound empathy ```

Question 27

onset of mdma

Answer 27

30-45min

Question 28

duration of mdma

Answer 28

4-6hr

Question 29

toxic effects of mdma

Answer 29

``` increased HR sweating muscle tension and cramping dry mouth teeth grinding blurred vision nausea ```

Question 30

mdma overdose

Answer 30

``` convulsions hyperthermia behavioral chnages rhabdomyolysis intravascular coagulation acute renal failure ```

Question 31

type of mdma dependence

Answer 31

tolarance develops psychological dependeance no physiological dependence