Addiction Flashcards
describe impulsive stage
binge intoxication – pleasureable effects — abstinence — reward craving
compulsive stage
prolonged intoxication — relief – protracted abstinence negative affect — relief craving
circuits involved in drug abuse and addiction
memory/learning
motivation/drive
inhibitory control
reward
addicted vs non addicted brain
increased reward and memory and decreased inhibtoroy control feeds into drive
pathways involved in addiction
functions
serotonin
increased risk of drug interactions
dose of drugs taken genetics diet reduced liver or kidney function increased age polypharmacy poly substance abuse comorbidities
3 types of di effects
synergistic
additive
antagonist
ginkgo biloba
increase bleeding
st johns wort
interacts with many anti depressants
ephedra
interacts with other stimulants
kava kava
adds to the sedative effect
serious effects with parkinson drugs
dopamine involved in
movement pleasure behaviour reward euphoris
serotonin involved in
body temp cognitive function regulation of emotions regulate appetite sleep/wake cycle secual function
noradrenergic pathway involved in
flight flight or freeze
increased HR, BP
peripheral blood vessel contract
blood diverted to skeletal muscle
gaba pathway involved in
calming
decreased anxiety
relaxation
