for midterm Flashcards
what colonizes plastic catheters
staphylococcus epidermis
what causes skin infections
staphylcoccus aureus
what bacteria species for large intestine
Bacteroides
what maintain low pH of vagina
lactobacillus
large skin lesions w bright red outer border and partially clear central area
early localized lyme disease
chills, fever, cardiovascular instability
bacteremia
stupor (near unconscious and stiff neck)
meninges/cerebrospinal fluid needs to be evaluated
gram stain what colors
+ –> purple
- –> pink/red
acid fast stain: acid fast bacilli what color
pink/red
india ink useful for what and how identified
crytococcus neofarmus in CSF
identified by large, transparent capsules that displace the ink
potassium hydroxide prep spares what
spares fungi
blood agar , sheep/horse what kind of media
enriched
for catalse test + or -
stephylococci
streptococci and enterococci
stephylococci –> +
steptococci and enterococci –> -
complement fixation solution will turn what color if negative
pink
range for pyschrophil, mesophil, thermophil, and which one for human pathogens
psychohrils (0-20 C)
mesophils (20-45 C)
Thermoohils (45-90 C)
most human pathogens aremesophils
human pathogen pH
7-7.4
ETC how much ATP/Mol glucose vs substrate level phosphorylation
38 vs 2
beta-lactams (penicillin and cephalosporins)
inhibition of cell wall synthesis
polymixins (neomycin and bacitarcin)
alteration of cytosolic membrane integrity
(displace mg and ca)
erythromycin
binds to 50S ribosomal subunit and inhibits peptidyl transferases
(inhibition of ribosomal protein synthesis)
clindamycin
binds to 50S ribosomal subunit and inhibits RNA-dependent protein synthesis
(inhibition of ribosomal protein synthesis)
tetracyclines
binds to 30S ribosomal subunit and inhibits binding of tRNA to mRNA
(inhibition of ribosomal protein synthesis)
metronidazole
reduction of 5 nitro group
suppression of nucleic acid syntehsis
quinolones
inhibit DNA supercoiling by DNA gyrase
suppression of nucleic acid synthesis
sulfonamides
blocks conversion of PABA to dihydrofolic acid
inhibition of folic acid synthesis
conjugation
cell to cell contact
transduction
phage vector
trasformation
naked DNA
Griffith mice experimentation was R virulent or S
R
crusted skin lesion
impetigo
infection of skin tissue that involves subcutaneous tissue, appears red, shiny, hot, swollen
cellulitis
collection of pus
abscess
small superficial abscess involving hair follicles
folliculitis
subcutaneous abscess that involves an hair follicle and surround tissue
furnuncle (boil)
clusters of furnucle connected subcutaneously, causing deeper suppuration and scarring
carbuncle
caused by exotoxin TSST-1
fever, nausea, vomiting, watery diarrhea, erythematous rash, hypotension, and desquamation of palms and soles
toxic shock syndrome
caused by exfoliative toxin A and B
fine sheets of skin peeling to reveal moist red skin beneath
rapid healing
low mortality
mainly affects neonates
scalded skin syndrome
what sticks to catheters, has slime
staph epidermis
what is main player for UTI
staph saprophyticus
streptococcus gram what, catalase what, virulent strain encapsulated or not
gram +
catalse -
viruelent strain encapsulated
fastidious
beta-hemolytic
alpha-hemolytic
gamma-hemolytic
beta - RBC completely lysed
alpha - RBC partially lysed
gamma - RBC not lysed
strep pyogenes (group A) where
skin infections, nasopharynx
step. agalctiae (group B) where
vagina
entercoccus fecalise (group D) where
intestine
strawberry tongue, red rash on body
scarlet fever
fiery red, advacing erythema on face or lower limbs
erysipelas
puffy face, darker urine, hypertension
actue glomerulonphritis
arthritis, carditis, fever, rash
rheumatic fever
acetylcholine, serotonin, GABA are what kind of channel receptors
ligand gated ion channel receptors
phospholipase C breaks down what into what
PIP2 –> DAG + IP3
what does Dag do
stimulate protein kinase C
what does IP3 do
binds to recptor of ER, releases Ca2+
rapid increase of cytosolic IP3 and Dag means stimulation of what
stimulation of PLCB
arachidonic acid converts metabolites to what
eicosanoids
NSAIDS targets what
cyclooxygenase
cyclooxygenase produces what
thromboxanes, prostaglandins, prostclyclins
5-lipoxygenase produces what
leukotrienes, HETE
epoxygenase produces what
HETE, EET
HETE and EET help w what
Ca2+ release and cell proliferation
phospholipase A2 releases what
arachidonic acid
atrial natruiretic peptide (ANP) does what
acts of vascular smooth muscle to dilate blood vessels, enhances Na+ excretion in urine
increased cGMP does what
relaxes vascular smooth muscle and dilates blood vessels
soluable guanylyl cyclase receptor which does what
NO, helps w blood flow and pressure
viagra inhibits what
PDE5 (which stops cGAMP which stops increased blood flow)
inside the cell high or low K, Na, Cl
Na and Cl low inside
K high inside
B-CDK1 involved w what cell phase
M phase
D-CDK4/6 involved w what cell phase
G1 phase
A-CDK2 involved in what cell phase
S phase
INK4 inhibits what
CDK4/6
cip/kip affects what
CDK1/2
mitogens do what
inhibit inhibitors
presence of mitogens, cyclin D-CDK4/6 phosphorylates what which does what
phosphorylates Rb protein (allows E2F)
endocrine vs paracrine signaling
endocrine - distant signaling
paracrine - neighbor signaling
SLCs, GLUT1 example of what
carriers