FOCUS Flashcards
EXPLAIN SINGLE STRAND BREAK
OCCURS IN DNA
AKA POINT MUTATION
REPAIRS
EXPLAIN DOUBLE STRAND BREAK FRAMESHIRT
OCCURS IN DNA
BREAKS IN PHOSPH. CHAIN AT DIFF LEVELS
CAN REPAIR BUT HARDER
EXPLAIN DOUBLE STRAND BREAK
OCCURS IN DNA
BREAKS IN PHOSPH. ON SAME LEVELS
WORST DNA. - REPLICATES DAMAGED INFO
MUTATION OCCURS WHEN?
CROSS LINKING
EXPLAIN RESTITUTION
CHROMOSOME
BREAK & REJOIN
NO DAMAGE
EXPLAIN DELETION
CHROMOSOME
ACENTRIC FRAGMENT RESULTS
EXPLAIN BROKEN END ARRANGEMENT
CHROMOSOME
1 CHROMOSOME = RINGS / REPO DEATH
2 CHROMOSOME = DEATH OR REPLICATED MUTATIONS TRANSLOCATION
WORST CHROM
INSTANT DEATH
1000 Gy in SECONDS
REPRODUCTIVE DEATH
1 - 10 Gy
Cant reproduce / pass on da,age
MITOTIC DEATH
AKA: GENETIC DEATH
MITOTIC DELAY
.01 Gy
CELL DONT DIVIDE ON TIME
HEMATOLOGIC DEPRESSION / BLOOD CHANGES
.25 Gy
LD 50/30
LD 50/60
LD 100
LETHAL DOSE
50/30 = 300-400 rad / 3 - 4 Gy
50/60 = 350 rad / 3.5 Gy
100 = 600 rad / 6 - 10 Gy
GESTATIONAL TOTAL DOSE EQUIVALENT FOR EMBRYO/FETUS OF OCCUPATIONAL WORKER?
5 mSv
.5 rem
GESTATIONAL = TOTAL
MONTHLY DOSE EQUIVALENT FOR EMBRYO/FETUS OF OCCUPATIONAL WORKER?
.5 mSv
.05 rem
TEMPORARY STERILITY
PERMANENT STERILITY
TEMP = 2 Gy (200 rad)
PERM = 5 - 6 Gy (500 - 600 rad)
CUMULATIVE WHOLE BODY EFFECTIVE DOSE
AGE X 10 mSv
AGE X 1 rem
ANNUAL SKIN OF EXTREMITIES & ORGANS OF OCCUPATIONAL WORKER
500 mSv
50 rem
EFFECTIVE DOSE LIMITS ARE BASED ON WHICH RESPONSE CURVE?
LINEAR NONTHRESHOLD
SOMATIC OCCURS
LATE / YEARS AFTER