FMS Week 9: Regeneration and Repair Flashcards
Causes of Tissue Injury
8 Listed
Tissue Adaptations
4 Listed
- Hyperplasia
- Hypertrophy
- Atrophy
- Metaplasia
What do you see?
- Stratum corneum destroyed
- neutrophils (forbidden this is acute process)
What do you see?
neutrophils in the epithelium (forbidden than is an acute process)
Integrins action
signal transduction that there is damage taking place
what is the signal saying?
What is this and its significance in injury?
The basement membrane divides to replace dying cells from damage detected by integrin signaling
Macrophage Growth Factors
4 Listed
- EGF
- TGF-α
- FGFs
- TGF-β
What are these cells?
- showing keratinocytes
- macrophage bot left
- top right fibroblast
What is the chance there will be regeneration here?
6 Listed
- None
- very necrotic
- no cells left
- angiogenesis will take place
- macrophages and mesenchymal will come in VEGF, FGF
- fibroblasts lay down collagen and scar formation
What do you see?
granulation tissue
blood vessels
fibroblasts
construction site
What do you see?
- granulation tissue
- blood vessels
- fibroblasts
- construction site
scar
How is collagen made?
need vitamin C for tissue repair
Tissue Examples based on proliferative capacity
3 Listed
- Permanent Tissues
- Stable Tissues
- Labile Tissues
Permanent tissues Properties
3 Listed
Permanent Tissue Examples
2 Listed
- Neurons
- Cardiac Muscle Cells
Stable Tissues Properties
6 Listed
A Stable tissue that can divide?
Liver Cells
Stable Tissues Cell Cycle
Tend to be quiescent in G0 but can go back into the cell cycle
Labile Tissues Properties
4 Listed
Labile Tissue Examples
3 Listed
- Hematopoietic cells of bone
- Surface epithelia
- Gastrointestinal columnar epithelium
Stem Cell Homeostasis
