FMS Week 10 Systemic Lupus Erythematosus

Question 1

Systemic Lupus Erythematosus: Affected Organ Systems

6 Listed

Answer 1

Question 2

Systemic Lupus Erythematosus: Goals of Therapy

3 Listed

Answer 2

Question 3

Systemic Lupus Erythematosus: Mild Disease can be treated with?

3 Listed

Answer 3

Question 4

Systemic Lupus Erythematosus: Severe Disease can be treated with?

2 Listed

Answer 4

Question 5

Treatment of SLE patients with Prednisone is associated with increased risk of _________

Answer 5

Cardiovascular Events

Question 6

Steroid-sparing Therapy Challenge

2 Listed

Answer 6

• The onset of therapeutic response for immunosuppressants is slower with prednisone
• Patients often need immediate relief

Question 7

Steroid-sparing therapy organ involvement

Answer 7

Organ involvement may influence choice

• If a primary symptom is arthritis, methotrexate, hydroxychloroquine, or mycophenolate mofetiil
• For photosensitive rashes, azathioprine, or leflunomide

Question 8

Steroid-sparing therapy: if the primary symptom is arthritis?

3 Listed

Answer 8

• Methotrexate
• hydroxychloroquine
• mycophenolate mofetil

Question 9

Steroid-sparing therapy: For photosensitive rashes?

2 Listed

Answer 9

• azathioprine
• leflunomide

Question 10

Methotrexate can cause __________

Answer 10

Photosensitive Rash

Question 11

Hydroxychloroquine MOA

Answer 11

MOA in SLE is not known

Question 12

Hydroxychloroquine Reduces

Answer 12

• Skin inflammation
• mouth sores
• joint pain

Question 13

Hydroxychloroquine Toxicities

7 Listed

Answer 13

• headache
• dizziness
• hair loss
• nausea
• muscle pain
• rash and itching
• may worsen psoriasis

Question 14

Hydroxychloroquine Rare but serious toxicities

4 Listed

Answer 14

• Leukopenia (reduction of the number of white cells)
• Thrombocytopenia (low blood platelet count)
• anemia
• retinal damage

Question 15

Hydroxychloroquine​ Warning

Answer 15

G6PD deficiency associated with severe anemia

Question 16

Hydroxychloroquine Irreversible retinal toxicity

Answer 16

Question 17

Azathioprine MOA

Answer 17

6-thioguanine metabolite exerts cytotoxic and immunosuppressive actions

Question 18

Azathioprine toxicity

3 listed

Answer 18

• can cause myelotoxicity (bone marrow suppression) and hepatotoxicity
• should run CBC and liver function tests

Question 19

Azathioprine: CBC

Answer 19

if lymphocyte count is low but the liver function test is normal, then low lymphocyte count is probably not due to a drug toxicity, as low lymphocyte count is often associated with SLE

Question 20

Lupus Nephritis and end-stage renal disease

Answer 20

at 10-year follow up 20% have end-stage renal disease

Question 21

Lupus Nephritis: Induction and maintenance therapies

2 Listed

Answer 21

• Mycophenolate mofetil (MMF)
• Cyclophosphamide

Question 22

Lupus Nephritis: Prednisone and cyclophosphamide

Answer 22

Question 23

Mycophenolate Mofetil (MMF) and Cyclophosphamide for the treatment of lupus nephritis

2 Listed

Answer 23

Question 24

Cyclophosphamide toxicities include increased risk of?

3 Listed

Answer 24

• Infection
• Amenorrhea
• ovarian toxicity

Question 25

MMF AKA

Answer 25

Mycophenolate Mofetil

Question 26

MMF may be _______ toxic than cyclophosphamide

Answer 26

less

Question 27

MMF is a _________ inhibitor of ________ and \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_.

Answer 27

Selective, B and T cell Proliferation

Question 28

Treatment of Resistant lupus nephritis 3 listed

Answer 28

Question 29

Eicosanoids

Answer 29

Question 30

Organ-System Effects of Eicosanoids 6 Listed

Answer 30

Question 31

Cardiovascular System Actions of Prostaglandins

Answer 31

Question 32

Cardiovascular System Actions of Leukotrienes

Answer 32

Question 33

Cardiovascular System Actions of Thromboxanes

Answer 33

Question 34

Prostoglandins in the kidney

Answer 34

Question 35

Pulmonary System

Answer 35

Question 36

Gastrointestinal System

Answer 36

Question 37

Bone formation and resorption

Answer 37

Question 38

Glucocorticoid effects in connective tissue, bone, calcium metabolism, metabolic effect

Answer 38

Question 39

Glucocorticoid Effects on CNS, ophthalmologic effects, immunologic function

Answer 39