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FMS > FMS Week 10 Systemic Lupus Erythematosus > Flashcards

FMS Week 10 Systemic Lupus Erythematosus Flashcards

1
Q

Systemic Lupus Erythematosus: Affected Organ Systems

6 Listed

A
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2
Q

Systemic Lupus Erythematosus: Goals of Therapy

3 Listed

A
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3
Q

Systemic Lupus Erythematosus: Mild Disease can be treated with?

3 Listed

A
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4
Q

Systemic Lupus Erythematosus: Severe Disease can be treated with?

2 Listed

A
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5
Q

Treatment of SLE patients with Prednisone is associated with increased risk of _________

A

Cardiovascular Events

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6
Q

Steroid-sparing Therapy Challenge

2 Listed

A
  • The onset of therapeutic response for immunosuppressants is slower with prednisone
  • Patients often need immediate relief
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7
Q

Steroid-sparing therapy organ involvement

A

Organ involvement may influence choice

  • If a primary symptom is arthritis, methotrexate, hydroxychloroquine, or mycophenolate mofetiil
  • For photosensitive rashes, azathioprine, or leflunomide
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8
Q

Steroid-sparing therapy: if the primary symptom is arthritis?

3 Listed

A
  • Methotrexate
  • hydroxychloroquine
  • mycophenolate mofetil
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9
Q

Steroid-sparing therapy: For photosensitive rashes?

2 Listed

A
  • azathioprine
  • leflunomide
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10
Q

Methotrexate can cause __________

A

Photosensitive Rash

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11
Q

Hydroxychloroquine MOA

A

MOA in SLE is not known

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12
Q

Hydroxychloroquine Reduces

A
  • Skin inflammation
  • mouth sores
  • joint pain
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13
Q

Hydroxychloroquine Toxicities

7 Listed

A
  • headache
  • dizziness
  • hair loss
  • nausea
  • muscle pain
  • rash and itching
  • may worsen psoriasis
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14
Q

Hydroxychloroquine Rare but serious toxicities

4 Listed

A
  • Leukopenia (reduction of the number of white cells)
  • Thrombocytopenia (low blood platelet count)
  • anemia
  • retinal damage
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15
Q

Hydroxychloroquine​ Warning

A

G6PD deficiency associated with severe anemia

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16
Q

Hydroxychloroquine Irreversible retinal toxicity

A
17
Q

Azathioprine MOA

A

6-thioguanine metabolite exerts cytotoxic and immunosuppressive actions

18
Q

Azathioprine toxicity

3 listed

A
  • can cause myelotoxicity (bone marrow suppression) and hepatotoxicity
  • should run CBC and liver function tests
19
Q

Azathioprine: CBC

A

if lymphocyte count is low but the liver function test is normal, then low lymphocyte count is probably not due to a drug toxicity, as low lymphocyte count is often associated with SLE

20
Q

Lupus Nephritis and end-stage renal disease

A

at 10-year follow up 20% have end-stage renal disease

21
Q

Lupus Nephritis: Induction and maintenance therapies

2 Listed

A
  • Mycophenolate mofetil (MMF)
  • Cyclophosphamide
22
Q

Lupus Nephritis: Prednisone and cyclophosphamide

A
23
Q

Mycophenolate Mofetil (MMF) and Cyclophosphamide for the treatment of lupus nephritis

2 Listed

A
24
Q

Cyclophosphamide toxicities include increased risk of?

3 Listed

A
  • Infection
  • Amenorrhea
  • ovarian toxicity
25
Q

MMF AKA

A

Mycophenolate Mofetil

26
Q

MMF may be _______ toxic than cyclophosphamide

A

less

27
Q

MMF is a _________ inhibitor of ________ and ___________________.

A

Selective, B and T cell Proliferation

28
Q

Treatment of Resistant lupus nephritis

3 listed

A
29
Q

Eicosanoids

A
30
Q

Organ-System Effects of Eicosanoids

6 Listed

A
31
Q

Cardiovascular System Actions of Prostaglandins

A
32
Q

Cardiovascular System Actions of Leukotrienes

A
33
Q

Cardiovascular System Actions of Thromboxanes

A
34
Q

Prostoglandins in the kidney

A
35
Q

Pulmonary System

A
36
Q

Gastrointestinal System

A
37
Q

Bone formation and resorption

A
38
Q

Glucocorticoid effects in connective tissue, bone, calcium metabolism, metabolic effect

A
39
Q

Glucocorticoid Effects on CNS, ophthalmologic effects, immunologic function

A

FMS (34 decks)

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