FMS Week 9: Pathology of Chronic Inflammation Flashcards by Jay Sandoval

Q

Features of Acute Inflammation

A

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Q

Features of Chronic Inflammation

A

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Q

chronic inflammation is an outcome of?

A

Acute inflammation if the cause is not resolved

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Q

Causes of Chronic Inflammation

7 Listed

A

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Q

A

Tuberculosis

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Q

Tissue/Pathology?

A

Normal Lung Alveoli

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Q

Tissue/Pathology?

A

Tuberculosis associated with necrosis

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Q

Tissue/Pathology?

A

Tuberculosis associated with necrosis

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Q

Immune granulomas are caused when?

A

The inciting agents are difficult to eradicate, such as a persistant microbe or self-antigen

Persistant Infections

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Q

A

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Q

Cells in Chronic Inflammation

A

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Q

A

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Q

Tissue/Pathology?

A

Normal Lung

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Q

Tissue/Pathology?

A

Sarcoidosis

NOT associated with necrosis

A lot of fibrosis and fibroblasts

no neutrophils so chronic

Langerhans giant cells seen top right

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Q

Tissue/Pathology?

A

Sarcoidosis

NOT associated with necrosis

A lot of fibrosis and fibroblasts

no neutrophils so chronic

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Q

Hypersensitivity Disease Properties

4 Listed

A

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Q

Macrophage effector functions for inflammation and Tissue Injury

7 Listed

A

Q

Macrophage effector functions for Repair

4 Listed

A

Q

A

Q

A

Q

Tissue/Pathology?

A

Normal Colon

Q

Tissue/Pathology?

A

Crohn’s Disease

Architectural changes (Acute and Chronic)

lamina propria packed full of inflammatory cells

branching of glands, only one normal looking gland

has neutrophils because there is an acute aspect of IBD

Q

Tissue/Pathology?

A

IBD associated cancer

Colorectal Adenocarcinoma

arising from chronic inflammation from Crohn’s Disease

Q

Inflammatory Bowel Disease

Ulcerative Colitis and Crohn’s Disease Properties

A

Inflammation-associated cancers

* Free radicals cause DNA Damage * NFkB inhibits apoptosis * NFkB induces cell proliferation * Cytokines stimulate NFkB * Cytokines stimulate cell proliferation

Tissue/Pathology?

Foreign body Granuloma Giant cells macrophages fusing together to try to phagocytose material

Tissue/Pathology?

Foreign Body Granuloma

Foreign Body Granulomas are?

Biological responses to relatively inert foreign bodies

Foreign Body Granulomas are mediated by? 2 Listed

* Macrophage mediated * T cells are absent

Foreign body granulomas form around things such as? 4 Listed

* Talc * Sutures * implants * other fibers that are too large

Tissue/Pathology?

Normal Aortic Wall

Tissue/Pathology?

Aneurysm

An Aneurysm is?

Atherosclerosis is?

A Fatty streak formation - contains lipid-filled macrophages (foam cells) and activated T cells

Fibrous cap in Atherosclerosis 3 listed

* advanced stage to wall off the lesion but this can cause damage to the endothelial cells * the plaque can rupture and material inside plaque * blood clots can form

Atherosclerosis treated by? 3 Listed

* Statins * decrease leukocyte adhesion and NO * inhibits cholesterol synthsis