FMS Week 9: Pathology of Chronic Inflammation

Question 1

Features of Acute Inflammation

Answer 1

Question 2

Features of Chronic Inflammation

Answer 2

Question 3

chronic inflammation is an outcome of?

Answer 3

Acute inflammation if the cause is not resolved

Question 4

Causes of Chronic Inflammation

7 Listed

Answer 4

Question 5

Answer 5

Tuberculosis

Question 6

Tissue/Pathology?

Answer 6

Normal Lung Alveoli

Question 7

Tissue/Pathology?

Answer 7

Tuberculosis associated with necrosis

Question 8

Tissue/Pathology?

Answer 8

Tuberculosis associated with necrosis

Question 9

Immune granulomas are caused when?

Answer 9

The inciting agents are difficult to eradicate, such as a persistant microbe or self-antigen

Persistant Infections

Question 10

Answer 10

Question 11

Cells in Chronic Inflammation

Answer 11

Question 12

Answer 12

Question 13

Tissue/Pathology?

Answer 13

Normal Lung

Question 14

Tissue/Pathology?

Answer 14

Sarcoidosis

NOT associated with necrosis

A lot of fibrosis and fibroblasts

no neutrophils so chronic

Langerhans giant cells seen top right

Question 15

Tissue/Pathology?

Answer 15

Sarcoidosis

NOT associated with necrosis

A lot of fibrosis and fibroblasts

no neutrophils so chronic

Question 16

Hypersensitivity Disease Properties

4 Listed

Answer 16

Question 17

Macrophage effector functions for inflammation and Tissue Injury

7 Listed

Answer 17

Question 18

Macrophage effector functions for Repair

4 Listed

Answer 18

Question 19

Answer 19

Question 20

Answer 20

Question 21

Tissue/Pathology?

Answer 21

Normal Colon

Question 22

Tissue/Pathology?

Answer 22

Crohn’s Disease

Architectural changes (Acute and Chronic)

lamina propria packed full of inflammatory cells

branching of glands, only one normal looking gland

has neutrophils because there is an acute aspect of IBD

Question 23

Tissue/Pathology?

Answer 23

IBD associated cancer

Colorectal Adenocarcinoma

arising from chronic inflammation from Crohn’s Disease

Question 24

Inflammatory Bowel Disease

Ulcerative Colitis and Crohn’s Disease Properties

Answer 24

Question 25

Inflammation-associated cancers

Answer 25

• Free radicals cause DNA Damage
• NFkB inhibits apoptosis
• NFkB induces cell proliferation
• Cytokines stimulate NFkB
• Cytokines stimulate cell proliferation

Question 26

Answer 26

Question 27

Answer 27

Question 28

Answer 28

Question 29

Tissue/Pathology?

Answer 29

Foreign body Granuloma

Giant cells macrophages fusing together to try to phagocytose material

Question 30

Tissue/Pathology?

Answer 30

Foreign Body Granuloma

Question 31

Foreign Body Granulomas are?

Answer 31

Biological responses to relatively inert foreign bodies

Question 32

Foreign Body Granulomas are mediated by?

2 Listed

Answer 32

• Macrophage mediated
• T cells are absent

Question 33

Foreign body granulomas form around things such as?

4 Listed

Answer 33

• Talc
• Sutures
• implants
• other fibers that are too large

Question 34

Answer 34

Question 35

Tissue/Pathology?

Answer 35

Normal Aortic Wall

Question 36

Tissue/Pathology?

Answer 36

Aneurysm

Question 37

An Aneurysm is?

Answer 37

Question 38

Atherosclerosis is?

Answer 38

A Fatty streak formation - contains lipid-filled macrophages (foam cells) and activated T cells

Question 39

Fibrous cap in Atherosclerosis

3 listed

Answer 39

• advanced stage to wall off the lesion but this can cause damage to the endothelial cells
• the plaque can rupture and material inside plaque
• blood clots can form

Question 40

Atherosclerosis treated by?

3 Listed

Answer 40

• Statins
• decrease leukocyte adhesion and NO
• inhibits cholesterol synthsis