FM1 Pt3-10 Therapeutics for cats Flashcards
Why must special care be taken when administering drugs to cats?
Cats have unique differences in drug metabolism, especially in phase II processes, and have more vulnerable haemoglobin, which makes them susceptible to certain drug toxicities.
What is a major difference between cats and dogs in drug metabolism?
Cats are deficient in glucuronidation, a phase II metabolic process, making them more susceptible to toxicity from drugs like paracetamol.
How does feline haemoglobin differ from canine haemoglobin in drug reactions?
Feline haemoglobin is more vulnerable to oxidation, making cats more prone to methaemoglobinaemia.
What is a significant risk when using the chemotherapeutic drug cisplatin in cats?
Cisplatin causes fatal, acute pulmonary oedema in cats.
Why is paracetamol (acetaminophen) dangerous for cats?
It causes methaemoglobinaemia due to their deficiency in glucuronidation, which can lead to fatal toxicity.
What are the potential side effects of using aspirin in cats?
Aspirin can cause hypersensitivity, hyperthermia, and dyspnoea due to prolonged persistence in the body.
Why should diazepam be used with caution in cats?
Repeated oral doses of diazepam can cause idiosyncratic fatal hepatic necrosis in cats.
What should be monitored when using doxorubicin in cats?
Renal function should be monitored as doxorubicin is associated with renal failure in cats.
What is a critical consideration when using permethrin-based flea treatments on cats?
Permethrin can cause severe neurological signs, including seizures and coma, especially if products intended for dogs are used on cats.
Why must doxycycline and clindamycin be administered with water or food in cats?
These antibiotics can cause esophageal damage if not followed by water or food, potentially leading to esophageal strictures.
What can happen if enrofloxacin is administered to cats?
Enrofloxacin can cause acute retinal degeneration and blindness in cats, so alternative antibiotics may be safer.
What are idiosyncratic adverse effects in drug reactions?
Unpredictable and severe effects that can occur in cats, making the use of certain drugs risky without thorough vet supervision.
