Fluid & Electrolytes Flashcards
Define Electrolyte
A solute that develops an electrical charge (sodium and potassium).
Intracellular fluid
Fluid contained within the cells. 40% of body weight and is responsible for cell function and metabolism. ~28L in adult
Extracellular fluid
Fluid outside the cells. 20% body weight, carries water, oxygen, electrolytes, nutrients to cells and removes waste products from cellular ,metabolism. ~14L in adult
Major electrolytes in ICF; cations and anion
Cations: Potassium, magnesium
Anion: phosphate
Main electrolytes in ECF; cations and anion
Cations: sodium, chloride
Anion: bicarbonate
Define interstitial fluid
ECF located in the spaces between the cells. Excess fluid here is called edema. Second spacing
Define intravascular fluid
ECF located within the blood vessels. It is the plasma located in the blood. Transports blood cells
Define transcellular fluid
ECF that includes specialized fluids that are contained in body spaces ( cerebrospinal, pleural, peritoneal, and synovial fluids) and digestive juices. ~1L
Fluid movement into a compartment is known as third spacing (Ascities).
Define osmolality (tonicity)
The concentration of solutes creating pressure in body fluid.
Isotonic solution
Of the same osmolality of blood ; no osmosis will occur
Hypotonic solution
Of lower osmolality than blood ; water will move into cells by osmosis from vascular system
Hypertonic solution
Contains a higher concentration of solutes than blood ; water moves by osmosis out of cells into ECF
Define osmosis
The movement of water (passive) from a lower solute concentration to a higher solute concentration to achieve dilution of higher solute concentration to reach equilibrium
Define diffusion
Movement (passive) of molecules of a solute from a higher concentration to a lower concentration to reach equilibrium
Factors affecting rate of diffusion
Size of molecule, concentration of solution, and temperature of solution.
What are crystalliods
Solutes that readily dissolve ( electrolytes)
What are colloids
Larger molecules that do not dissolve readily ( proteins)
Define filtration
The movement of both water and smaller solutes from an area of high pressure to area of low pressure
Define hydrostatic pressure
The force created by fluid within a closed system ; responsible for normal circulation of blood
High pressure (arteries) to low pressure (capillaries and veins)
Define osmotic pressure
The power of a solution to draw water.
A highly concentrated solution draws water and has a high osmotic pressure.
Filtration pressure
When hydrostatic pressure exceeds osmotic pressure fluid leaves the vessels.
Represents the net pressures that move fluid and solutes
Active transport
Occurs when molecules move across cell membranes against the concentration gradient with the use of ATP (from an area of low concentration to an area of high concentration)
Ex: sodium-potassium pump
Define Solute
Solid substance that dissolves in body fluids
Factors that increase plasma osmolality
excessive fluid loss, excessive sodium intake, and decreased fluid intake.
changes in plasma osmolality signal which center in the brain
the thirst center in the hypothalamus
sensible fluid loss
measurable and perceived
ex: urine 1500mL, diarrhea, ostomy, gastric drainage, skin 300-600mL, feces 100-200mL
insensible fluid loss
loss that we do not perceive and cannot measure accounts for about 900mL per day
ex: lungs about 300mL per day
what is the principal regulator of fluid and electrolyte balance
kidneys
what hormones are involved in regulation
ADH, Renin-Angiotensin System, Aldosterone, Thyroid, ANP & BNP & CNP
define ADH and function
pressure sensors from the vascular system stimulate or inhibit the release of antidiuretic hormone from pituitary gland. ADH causes kidneys to retain fluid. ADH is also produced in response to a rise in serum osmolality, fever, pain, stress, and some opioids.
ex: if fluid volume in the vascular system is low, fluid pressures decrease, and more ADH is released to signal kidneys to retain more fluid.
define Renin-Angiotensin System and function
when intravascular fluid volume is decreased, receptors in the glomeruli respond to the decreased perfusion of the kidneys by releasing renin. Renin is responsible for a chain reaction that converts angiotensin into angiotensin 2.
Angiotensin 2 acts on the nephrons to retain sodium and water and directs the adrenal cortex to release aldosterone.
define aldosterone and function
when released, it stimulates the distal tubules to reabsorb sodium and excrete potassium. with this, water is passively reabsorbed thereby increasing fluid volume and renin is not released and this process stops.
define thyroid hormone and function
affects fluid volume by influencing cardiac output. and increase in thyroid hormone causes increase in CO and increases glomerular filtration rate and urine output. a decrease does the opposite.
define Natriuresis (ANP, BNP, CNP) and functions
natriuretic is the discharge of sodium through urine
BNP is released from brain and right atrium. can be measured to help determine presence of heart failure with fluid excess and to distinguish heart failure from pulmonary edema.
Sodium (Na+)
major cation in the ECF. primary function to regulate fluid volume. reabsorbed and excreted by kidneys.
Moves by active transport via sodium-potassium pump, regulated by ADH and aldosterone levels (pituitary)
Potassium (K+)
major cation in the ICF (98% in icf). key electrolyte in cellular metabolism. necessary transmission/conduction of nerve and muscle impulses, maintenance of cardiac rhythms, cellular growth, acid-base balance. Na+ K+ pump (3sodiums out 2 potassiums in) regulated by aldosterone. excreted and conserved primarily by kidneys ~90% daily K+. Sodium retention = potassium loss in urine
Calcium (Ca++)
responsible for bone health, neuromuscular, and cardiac function. essential factor in blood clotting. 99% is found in bones and teeth, the remainder 1% circulates in the blood and affects system functions. as serum calcium levels drop, ca++ is leached from bones and into the blood to compensate.
Magnesium (Mg++)
mineral used in more than 300 biochemical reactions in the body. like calcium, only about 50-60% is found in the bone. 2% is in the ECF. coenzyme in metabolism of protein and carbs. required for nucleic acid and protein synthesis. necessary for na-K pump. skeletal muscle relaxation.
Mistaken for Ca+ imbalance; if you replace K, also replace Mg++
Chloride (Cl-)
most abundant anion in the ECF. usually bound with other ions especially sodium or potassium. essential for hydrochloric production for gastric sectretions. found in food high in sodium
Phosphorus (Phosphate [Po4-])
Most abundant ICF anion. most phosphorous in the body is combined with oxygen forming phosphate-mostly bound with calcium in teeth and bones as calcium phosphate.
phosphate and calcium exist in an inverse relationship.
Phosphate in the ECF is known as phosphorus.
Bicarbonate (HCO3-)
present in both ICF and ECF. The kidneys regulate EC bicarbonate to maintain acid-base balance. when serum levels rise, kidneys excrete excess bicarbonate. It is not consumed in the diet but is produced by the body to meet current needs. a major buffer.
what is an acid
any compound that contains hydrogen ions that can be released. acids are referred to cation donors.
what is a base/alkali
a compound that combines with (accepts) hydrogen ions in solution. bases are referred to cation receptors.
what is pH
the amount of acid or base present in a solution; measured as 1-14. 1-6.9 as being acidic 7 is neutral and 7.1-14 is basic.
Hgb Female
12-16 g/dL
Hgb Male
14-18 g/dL