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IMSE LABORATORY > FINALS - SYPHILIS > Flashcards

FINALS - SYPHILIS Flashcards

1
Q

agent for syphilis

A

treponema pallidum subspecies pallidum

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2
Q

syphilis is also known as

A

great for
evil fox
Spanish disease
great imitator - bacteria

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3
Q

why is it termed as spanish disease?

A

Christopher Columbus brought into the New world syphilis

old world - small fox

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4
Q

a great imitator in parasitology

A

trichinella spiralis

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5
Q

MOT of syphilis

A

SEX
transpacental
congenital
parental
blood transfusion

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6
Q

syphilis is least to be transmitted via

A

blood transfusio

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7
Q

why is it blood transfusion is the least MOT

A

can’t tolerate cold temperature - if treponema stays in blood bag for more than 72hrs - it will die

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8
Q

agents found in blood

A

HIV, hepa B and C, and malaria

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9
Q

stages of syphilis

A

primary
secondary
latent
tertiary

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10
Q

Infection is localized

A

primary stage

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11
Q

days of infection for primary syphilis

A

1-6 weeks after infection

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12
Q

a lesion starting to occur in primary syphilis

A

hard chancre

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13
Q

greenish lesions that are isolated only in the part you used for sexual contact

A

hard chancre

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14
Q

is primary stage infectious?

A

yes, very infectious

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15
Q

lab test for primary syphilis

A

dark field microscopy only
(no antibodies yet)

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16
Q

soft chancre is for

A

Haemophilus ducreyi

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17
Q

characterized by lymphadenopathy or enlargement of lymph nodes, malaise, fever, pharyngitis, and rash or mucous membranes

A

secondary syphilis

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18
Q

duration of secondary syphilis

A

1-2 months

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19
Q

in secondary syphilis, appearance of rash like lesions called

A

Condylomata lata

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20
Q

lab test for secondary syphilis

A

antibodies and dark field microscopy

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21
Q

a stage which is non infectious

A

latent syphilis

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22
Q

asymptomatic stage

A

latent syphilis stage

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23
Q

when do latent stage starts?

A

after 2nd year of infection

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24
Q

last test for latent syphilis

A

serologic test only

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25
Q

clinical time for tertiary syphilis

A

10-30 yrs

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26
Q

3 major manifestation of tertiary syphils

A

gummatous syphilis
cardiovascular syphilis
neurosyphilis (csf)

congenital syphilis

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27
Q

in congenital syphilis, it is characterized by :

A

hutchinson triad

28
Q

what is under the hutchinson triad

A

hutchinson’s teeth - notched teeth
interstitial keratitis
nerve deafness

29
Q

serologic test

A

non treponemal test
treponemal test

30
Q

non treponemal test examples

A

wassermann test
venereal disease research laboratory

31
Q

wasserman test is made by

A

august paul von wasserman (1906)

32
Q

antigen source used for wasserman test

A

crude liver extract from a fetus with syphilis

33
Q

principle of wasserman test

A

complement fixation

34
Q

do vdrl and rpr use complement proteins?

A

nope, so they need inactivated serum

35
Q

how to inactivate serum in vdrl

A

heating

36
Q

purpose of inactivating serum

A

to remove complement

37
Q

in vdrl - inactivating serum

temp and time

A

56* C for 30 mns

stand to room temp

another 10 mns - 56*C again

38
Q

principle of VDRL -

A

flocculation

39
Q

reagent of vdrl is made up of

A

cardiolipin
lecithin
cholesterol

40
Q

the component of vdrl that detects reagin

A

cardiolipin

41
Q

the anti body for syphilis

A

reagin

42
Q

VDRL rotator time and speed for serum

speed
time

A

speed 180 rpm
time 4 mns

43
Q

VDRL rotator time and speed for csf

speed
time

A

speed 180 rpm
time 8 mns

44
Q

diameter to be considered positive in serum

A

14 mm

45
Q

diameter to be considered positive in csf

A

16 mm

46
Q

depth

A

1.75 mm

47
Q

antigen diluting needle for vdrl

A

hamilton syringe

48
Q

qualitative svdrl gauge

A

18 gauge; 60 drops/ml

49
Q

quantitative svdrl gauge

A

19 gauge - 75 drops/ml

50
Q

csf vdrl gauge

A

21 and 22 gauge - 100 drops/ml

51
Q

reporting for vdrl

non reactive

A

no clumps

52
Q

reporting for vdrl

weakly reactive

A

small clump

53
Q

reporting for vdrl

reactive

A

medium to large clumps

54
Q

false positive in vdrl

A

SLR, RA, IM, MALARIA,

55
Q

uses unheated serum

A

RPR - rapid plasma reagi

56
Q

principle of RPR

A

flocculation

57
Q

reagent or RPR

A

cardiolipin
lecithin
anti complement protein
charcoal
choline chloride
thimerosal

58
Q

component of the reagent of rpr that is for neutralizing

A

lecithin

59
Q

component of the reagent of rpr that is for inactivating serum chemically

A

choline chloride

60
Q

component of the reagent of rpr that is for visual

A

charcoal

61
Q

component of the reagent of rpr that is for preservative

A

thimerosal

62
Q

time and speed of rotator of rpr

A

speed 100 rpm
time 8 mns

63
Q

hamilton syringe of rpr

A

20 gauge needle - 60 drops per ml

64
Q

ring diameter for rpr

A

18 mm

65
Q
A

IMSE LABORATORY (8 decks)

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