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IMSE LABORATORY > FINALS - SYPHILIS > Flashcards

FINALS - SYPHILIS Flashcards

1
Q

agent for syphilis

A

treponema pallidum subspecies pallidum

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2
Q

syphilis is also known as

A

great for
evil fox
Spanish disease
great imitator - bacteria

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3
Q

why is it termed as spanish disease?

A

Christopher Columbus brought into the New world syphilis

old world - small fox

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4
Q

a great imitator in parasitology

A

trichinella spiralis

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5
Q

MOT of syphilis

A

SEX
transpacental
congenital
parental
blood transfusion

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6
Q

syphilis is least to be transmitted via

A

blood transfusio

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7
Q

why is it blood transfusion is the least MOT

A

can’t tolerate cold temperature - if treponema stays in blood bag for more than 72hrs - it will die

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8
Q

agents found in blood

A

HIV, hepa B and C, and malaria

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9
Q

stages of syphilis

A

primary
secondary
latent
tertiary

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10
Q

Infection is localized

A

primary stage

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11
Q

days of infection for primary syphilis

A

1-6 weeks after infection

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12
Q

a lesion starting to occur in primary syphilis

A

hard chancre

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13
Q

greenish lesions that are isolated only in the part you used for sexual contact

A

hard chancre

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14
Q

is primary stage infectious?

A

yes, very infectious

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15
Q

lab test for primary syphilis

A

dark field microscopy only
(no antibodies yet)

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16
Q

soft chancre is for

A

Haemophilus ducreyi

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17
Q

characterized by lymphadenopathy or enlargement of lymph nodes, malaise, fever, pharyngitis, and rash or mucous membranes

A

secondary syphilis

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18
Q

duration of secondary syphilis

A

1-2 months

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19
Q

in secondary syphilis, appearance of rash like lesions called

A

Condylomata lata

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20
Q

lab test for secondary syphilis

A

antibodies and dark field microscopy

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21
Q

a stage which is non infectious

A

latent syphilis

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22
Q

asymptomatic stage

A

latent syphilis stage

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23
Q

when do latent stage starts?

A

after 2nd year of infection

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24
Q

last test for latent syphilis

A

serologic test only

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25
clinical time for tertiary syphilis
10-30 yrs
26
3 major manifestation of tertiary syphils
gummatous syphilis cardiovascular syphilis neurosyphilis (csf) congenital syphilis
27
in congenital syphilis, it is characterized by :
hutchinson triad
28
what is under the hutchinson triad
hutchinson's teeth - notched teeth interstitial keratitis nerve deafness
29
serologic test
non treponemal test treponemal test
30
non treponemal test examples
wassermann test venereal disease research laboratory
31
wasserman test is made by
august paul von wasserman (1906)
32
antigen source used for wasserman test
crude liver extract from a fetus with syphilis
33
principle of wasserman test
complement fixation
34
do vdrl and rpr use complement proteins?
nope, so they need inactivated serum
35
how to inactivate serum in vdrl
heating
36
purpose of inactivating serum
to remove complement
37
in vdrl - inactivating serum temp and time
56* C for 30 mns stand to room temp another 10 mns - 56*C again
38
principle of VDRL -
flocculation
39
reagent of vdrl is made up of
cardiolipin lecithin cholesterol
40
the component of vdrl that detects reagin
cardiolipin
41
the anti body for syphilis
reagin
42
VDRL rotator time and speed for serum speed time
speed 180 rpm time 4 mns
43
VDRL rotator time and speed for csf speed time
speed 180 rpm time 8 mns
44
diameter to be considered positive in serum
14 mm
45
diameter to be considered positive in csf
16 mm
46
depth
1.75 mm
47
antigen diluting needle for vdrl
hamilton syringe
48
qualitative svdrl gauge
18 gauge; 60 drops/ml
49
quantitative svdrl gauge
19 gauge - 75 drops/ml
50
csf vdrl gauge
21 and 22 gauge - 100 drops/ml
51
reporting for vdrl non reactive
no clumps
52
reporting for vdrl weakly reactive
small clump
53
reporting for vdrl reactive
medium to large clumps
54
false positive in vdrl
SLR, RA, IM, MALARIA,
55
uses unheated serum
RPR - rapid plasma reagi
56
principle of RPR
flocculation
57
reagent or RPR
cardiolipin lecithin anti complement protein charcoal choline chloride thimerosal
58
component of the reagent of rpr that is for neutralizing
lecithin
59
component of the reagent of rpr that is for inactivating serum chemically
choline chloride
60
component of the reagent of rpr that is for visual
charcoal
61
component of the reagent of rpr that is for preservative
thimerosal
62
time and speed of rotator of rpr
speed 100 rpm time 8 mns
63
hamilton syringe of rpr
20 gauge needle - 60 drops per ml
64
ring diameter for rpr
18 mm
65

IMSE LABORATORY (8 decks)

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