Final Lecture Exam Flashcards
Hierarchy of Life
- Molecular/Chemical Level
- Cellular Level
- Tissue Level
- Organ Level
- Organ System
- Organism
Homeostasis
Having a stable internal environtment
Static equilibrium
If your body temperature stayed the same
Dynamic equilibrium
Not the same everyday (changes). There is a range that is accepted
Autoregulation
Regulation without help
Examples of autoregulation
Stomach
- Food puts off homeostasis, so it undergoes homeostasis to digest it
Running
- Blood to the heart increases by itself
Feed-forward
The ability to predict a change in homeostasis and begin to prepare for it before it happens
Examples of feed-forward
Your hungry and walk past a restaurant, your stomach growls, then it makes acid and enzymes to prepare for food
Types of Feedback (Loops)
- Positive feedback loop
2. Negative feedback loop
Positive feedback loop
Body’s response to stimulus is to exaggerate that stimulus; Used in situations where the only way to get back to homeostasis is to push through as fast as possible
Examples of positive feedback loops
Low body temperature.
Body’s response is to make it lower
Labor and Delivery
- Stimulus is cervical stretch
- Body responds by making oxytocin (by the hypothalamus)
- Oxytocin causes cervix to stretch
- Pitocin (being induced) speeds up positive feedback loop; oxytocin
Negative feedback loop
Body’s response to a stimulus is to revert the stimulus; The most important/most common type of regulation
What is the body’s first response to a stimulus
Recognizing the stimulus
Receptors
Recognizes a stimulus and sends information to the integration center
Integration center
(The brain, usually) Takes in information and determines if a response is necessary; If a response is necessary it sends information to the effector
Types of macromolecules
- Proteins
- Lipids
- Carbohydrates
- Nucleic acids
What is the monomer that is used to make proteins?
Amino acids
What is the monomer for lipids
Fatty acids
What is the monomer of carbohydrates
Monosaccharides
What is the monomer of nucleic acids
Nucleotides
Functions of proteins
Help with structure
Function of lipids
Store energy
Function of carbohydrates
Main source of energy
Function of nucleic acids
Make up genetic information
Activation energy
Energy that is needed to get a chemical reaction moving
Enzymes
Protein catalysts that our body uses that can be reused over and over
What is the function of enzymes
To make chemical reactions happen fast enough to maintain life
What do enzymes do
Lower the amount of activation energy required
Active site
Pockets that are formed from the what that the protein forms
A protein is only functional if
It folds into the correct shape
What must happen for a protein to be functional
It must turn into a 3D structure
Factors that influence enzyme activity
- pH
2. Temperature
When do enzymes not work as well
- Colder temperature
2. Hotter temperature
What happens to enzymes in colder temperatures
They slow down
What happens to enzymes in hotter temperature
It denatures
Denature
The 3D structure breaks down and it reverts to its primary structure
What happens when an enzyme denatures
The hydrophobic amino acids go into the water and are unprotected
Example of activation energy
Stirring sugar in water
Triglyceride
3 fatty acids (tri) that are connected with a glycerol (glyceride)
Triglyceride function
- Energy
- Used to store fatty acids (they are stored as triglycerides)
- Insulation
- Protection
(know 3)
Phospholipid
2 fatty acids attached to a phosphate group; amphipathic
Phospholipid function
Used in the plasma membrane to create a phospholipid bilayer and protect the hydrophobic parts (heads are hydrophilic, tails are hydrophobic)
Phospholipids are
Amphipathic
Amphipathic
Parts of the molecule are hydrophobic and parts are hydrophilic
Three ways phospholipids organize
- Hydrophilic heads on water surface, tails sticking out
- Circle with hydrophilic heads on the outside, tails are protected on the inside
- Bilayer
Bilayer
The plasma membrane is a phospholipid bilayer
What molecules pass through the plasma membrane freely
Hydrophobic
Most lipids are
Hydrophobic
Steroid function
Used for communcation
Nucleic acids function
Used to store information
What do you need for simple diffusion to occur?
A concentration gradient
What molecules move through the plasma membrane through simple diffusion
Small, hydrophobic molecules
What molecules use facilitated diffusion
Large, charged molecules because they are hydrophilic
Osmosis
Movement of water across a selectively permeable membrane
Osmotic pressure
The higher the solute concentration, the higher the osmotic pressure. The side with the more solute has osmotic pressure. This describes the amount of pull that a solution has on water
Example of osmotic pressure
- High osmotic pressure is needed by kidneys to pull water out of urine
- Small intestine pulls water out of food waste, so it needs high osmotic pressure
Tonicity
Describes the effect that a solution has on a cell
Isotonic
Describes a solution that has solute that matches the inside. Water moves in and out for every water molecule that goes out, another goes in, creating equilibrium
Hypotonic
Less solute in the solution than inside the cell, or more solute inside the cell than the outside (it is plump)
Hypertonic
More solute outside the cell than inside
Active transport
Moves things against the concentration gradient, from low to high; requires energy because it is not “natural”
Sodium-potassium exchange pump
There is more sodium outside than inside the cell, and more potassium inside than outside; They are moved against the concentration gradient using ATP
- an example of active transport
Endocytosis
Membrane makes a “bud” and pulls something in after it pinches off into the cell
Types of endocytosis
- Pinocytosis
- Phagocytosis
- Receptor mediated
Pinocytosis
Constantly randomly testing fluid from the environment that can be useful or useless
Phagocytosis
Pulls in specific things by reaching out and capturing things from the environment
Receptor mediated
Extremely specific because it has receptor proteins that have active sites that are specific for binding to molecules
Reflex
Automatic, reproducible response to a stimulus
How do you detect a stimulus?
By using a RECEPTOR that takes information about a stimulus and sends it to the INTEGRATION CENTER, which determines if the stimulus requires a response, if a response is needed it sends the information to an EFFECTOR which responds to the stimulus
Events in a reflex arc
- Arrival of stimulus and activation of receptor
- Activation of sensory neuron
- Information processing in the CNS
- Activation of a motor neuron
- Response by effector
Pain/withdraw reflex
Moves affected parts of the body away from the stimulus
Peripheral nervous system
All the neural tissue that is not in the brain or spinal cord
Types of PNS
- Afferent nervous system
2. Efferent nervous system
Afferent nervous system
System of neurons that brings sensory information from the body into the CNS
Efferent nervous system
Carries motor command information from the CNS to the body
Types of Efferent nervous system
- Somatic nervous system
2. Autonomic nervous system
Somatic nervous system
Carries efferent/motor commands to skeletal muscle
Autonomic nervous system
Controls everything that we move unconsciously
Function of the PNS
To bring sensory information to and from the CNS
Types of autonomic nervous system
- Sympathetic nervous system
2. Parasympathetic nervous system
Sympathetic nervous system
“Fight or flight”; increases heart and respiratory rate and shuts down the urinary system and digestive system to save energy
Parasympathetic nervous system
“Rest and digest”; stimulates the digestive and urinary systems, decreases heart and respiratory rate
Cell body
Soma
Parts of cell body
- Nucleus
2. Perikaryon
What is found in the perikaryon
All of the organelles that would be found in a normal cell
What does the perikaryon lack that other normal cells have, and what does this cause?
Centrioles, which makes neurons unable to divide
Nissl bodies
The equivalent of the rough ER in neurons; has ribosomes, which link amino acids and makes proteins, that cover the outside and makes it “rough”; causes the grey color
Axon hillock
This creates an action potential if a stimulus is strong enough for a response
Axolemma
The plasma membrane of the axon
Action potential
An electrical current
Synaptic terminal
The end of the telodendria; where the neuron communicates with another cell
Telodendria
The branches of the axon
Synaptic cleft/Synapse
The small gap between the synaptic terminal and the next tell
Membrane potential
An electrical charge; the charge on the inside of the membrane RELATIVE to the charge on the outside
Resting membrane potential
The resting phase of a neuron; when you don’t notice any stimuli from the environment
What is the mV for resting potential?
-70 mV
What things contribute to the negative charge
- Leak channels
- Sodium-potassium pump
- Intracellular proteins
Leak channel
Allows for the facilitated diffusion of sodium and potassium ions
Where are there more sodium ion?
Outside the membrane
Where are there more potassium ions?
Inside the membrane
Sodium and potassium have ____ charges
Positive
Potassium leaks ____, sodium leaks ____
Out; in
Does sodium or potassium leak faster?
Potassium leaks out faster than sodium leaks in
Potassium leaking out faster than sodium leaking in causes what
This lowers the charge inside the cell making it more negative
Sodium-potassium pump
Active transport; moves sodium out and potassium in; uses energy because it moves things against the gradient
Does sodium or potassium move in/out more?
More sodium is moving out than potassium is moving in
Intracellular proteins
Located right on the inside of the membrane; negative charge; makes the inside more negative than the outside
Graded potential
A stimulus that acts on a neuron at rest; a deviation from the resting membrane potential (more + or more -)
Types of graded potentials
- Depolarizing graded potential
2. Hyperpolarizing graded potential
Depolarizing graded potential
A deviation that makes membrane potential more positive/more like the outside
Depolarizing graded potential is also called
Excitatory post-synaptic potential (EPSP)
Hyperpolarizing graded potential
A deviation that makes membrane potential more negative/less like the outside
Hyperpolarizing graded potential is also called
Inhibitory post-synaptic potential (IPSP)
Summation
Adding more than 1 graded potential together; used to get to threshold
Types of summation
- Temporal summation
2. Spatial summation
Temporal summation
When we summate graded potentials from a single synapse
Explain temporal summation
One telodendrian synapses with another neuron. An action potential is sent through the telodendrian and neurotransmitters are sent through the synapse; happens one after another faster than the sodium-potassium pump can push out
Can you summate EPSP and IPSP at the same time in temporal summation?
No, you can only summate EPSP OR IPSP, not both at the same time; Because one synapse can only send one type of graded potential (EPSP or IPSP) and they would just cancel each other out
Spatial summation
When we summate graded potentials from multiple synapses; the sodium mixes; the synapses must be close together
What does summation do for graded potentials
Graded potentials are weak by themselves, so we have to summate them to reach threshold
Action potential
How neurons communicate; when the stimulus is so strong that the neuron gets to threshold, it will create this
Threshold
When a stimulus is strong enough to take it out of resting membrane potential; the point where a stimulus is so strong that it activates a sensory neuron
What is the graded potential “battle”?
EPSP is trying to bring sodium in and reach threshold while the sodium-potassium pumps are trying to pump sodium out and get away from threshold and back to resting membrane potential
How do you reach threshold?
There has to be more sodium coming in than the sodium-potassium pump can push back out
Volted-gated channel
A membrane potential (mV) causes it to open or close; has two gates: activation gate on outside of cell, inactivation gate on inside of cell
What happens to a volted-gated channel once you reach threshold?
The gates open and allows sodium to rush through until the membrane potential reaches 30 mV
When does the inactivation gate close?
When the membrane potential reaches 30 and stays closed until the neuron goes back to resting membrane potential
What happens once the membrane reaches -70mV (volted-gated channel)?
The inactivation gate opens and the activation gate closes
Describe the graph and what happens when the membrane potential reaches threshold
When the membrane potential reaches threshold, action potential begins and the membrane potential goes more and more positive, then it goes back to resting membrane potential
What can we tell from this graph?
- In this graph there is an EPSP that depolarizes
2. It must be summated because one EPSP will move it only about .5 mV
What happens when the cell reaches threshold?
Volted gated sodium channels open
Once the membrane reaches 30+ what happens?
- The inactivation gate of the volted gated sodium channel closes
- Volted gated potassium channels open and potassium rushed out