Final exam-transplant immuno Flashcards
Autografts are?
exchanges from one part to another part of the same individual
grafts exchanged between different individuals of identical constituites
isografts
grafts exchanged between non-identical members of the same species
allograft
grafts exchanged from members of different species
Xenograft
HLA-antigens are
co-dominantly expressed
strong barriers to transplantation are these antigens?
class I HLA-antigens (A and B)
What are the most important for transplantation?
Class II- three types
HLA-DR, HLA-DP, HLA-DQ
Direct allorecognition involves the T cell recognizing
unprocessed allogenic MHC molecules on graft APC’s
Indirect allorecognition involves T cell recognizing
processed peptide of allogenic MHC molecules bound to self MHC molecules on host APC
this type of rejection is caused by preformed antidonor antibodies and complement activated within minutes to hours
Hyperacute
reactivation of sensitized T cells within days of transplant rejection
Accelerated
primary activation of t cell in transplant rejection that takes days to weeks. involves cellular and vascular changes due to fibrosis
Acute rejection
immunologic and non-immunologic factors that take months to years to reject a transplant
Chronic
direct allorecognition pathway is the primary response to
graft transplant
the indirect allorecognition pathway is most important in?
Chronic rejection
Acute cellular involve the which T cells?
T helper 1
Acute vascular humoral involve which T cells?
T helper 2
after transplant, donor Dendritic cells migrate to?
lymph nodes
Chronic graft rejection occurs due to?
occlusion of blood vessels and ischemia of organ
which cells play an important role in triggering an acute rejection?
donor Dendritic cells
can CD4 and CD8 contribute to graft rejection?
yes
indirect allorecognition pathway contributes to which type of rejection?
acute
Does Chronic rejection respond to immunosuppressive therapy?
no
Fibrinopeptides lead to vascular permeability (vasodilation) that provide attractant of neutrophils and macrophages in the kinin cascade. Fibrinopeptides are a type of Non-immunological factor associated with?
allograft rejection
a test used to test recipient serum for performed antibodies against donor HLAs is?
Cross-matching
Corneal transplant, heart valve transplant, and bone/ tendon grafts are NOT important for?
ABO blood matching because of a barrier to transplantation
The first step in donor transplantation is?
ABO compatibility because of its strong surface antigens on many tissues
Universal donor blood?
type O
complement is activated by classical pathway. patient of blood type A received type B blood. what happens?
RBC lysis because of anti-B antibodies on the surface of type A blood group.
universal recipient?
AB blood
to identify HLAs which test is preformed?
tissue typing
success of transplantation is dependent on matching of?
MHC antigens
the spleen and lymph node provide a convenient source of?
lymphocytes for HLA typing
Microcytotoxicity test detects?
which Donors anti-serum to HLA antigens match the best with the recipient
ABO is major antigen and Cross matching is Minor
…..
a mixed lymphocyte reaction (MLR) is used in
class II HLA typing
you want to determine if the donor cells stimulate proliferation of recipient lymphocytes. you use a?
a mixed lymphocyte reaction (MLR) in class II HLA typing
Will proliferation occur in recipient tissue if the class II MHC antigens are different?
no. they MUST be the same for proliferation to occur
in Graft vs. Host disease, T cells from the transplanted organ react how?
attack host tissue
in host vs. graft disease. T cells from the host react how?
attack the transplanted organ
T cells enter the allograft when endothelial cells are activated in
non-immune injury of the graft
inability of the host immune system to reject allogenic cells due to the immunocompromised recipient causes?
Graft vs host disease.
reaction directed against MINOR H antigens derived from polypmorphc proetin preented CD8……
Graft vs host disease
The cornea is an immunologically
privileged site- free from the immune systems effects
