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immunology > Final exam-transplant immuno > Flashcards

Final exam-transplant immuno Flashcards

1
Q

Autografts are?

A

exchanges from one part to another part of the same individual

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2
Q

grafts exchanged between different individuals of identical constituites

A

isografts

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3
Q

grafts exchanged between non-identical members of the same species

A

allograft

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4
Q

grafts exchanged from members of different species

A

Xenograft

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5
Q

HLA-antigens are

A

co-dominantly expressed

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6
Q

strong barriers to transplantation are these antigens?

A

class I HLA-antigens (A and B)

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7
Q

What are the most important for transplantation?

A

Class II- three types

HLA-DR, HLA-DP, HLA-DQ

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8
Q

Direct allorecognition involves the T cell recognizing

A

unprocessed allogenic MHC molecules on graft APC’s

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9
Q

Indirect allorecognition involves T cell recognizing

A

processed peptide of allogenic MHC molecules bound to self MHC molecules on host APC

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10
Q

this type of rejection is caused by preformed antidonor antibodies and complement activated within minutes to hours

A

Hyperacute

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11
Q

reactivation of sensitized T cells within days of transplant rejection

A

Accelerated

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12
Q

primary activation of t cell in transplant rejection that takes days to weeks. involves cellular and vascular changes due to fibrosis

A

Acute rejection

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13
Q

immunologic and non-immunologic factors that take months to years to reject a transplant

A

Chronic

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14
Q

direct allorecognition pathway is the primary response to

A

graft transplant

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15
Q

the indirect allorecognition pathway is most important in?

A

Chronic rejection

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16
Q

Acute cellular involve the which T cells?

A

T helper 1

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17
Q

Acute vascular humoral involve which T cells?

A

T helper 2

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18
Q

after transplant, donor Dendritic cells migrate to?

A

lymph nodes

19
Q

Chronic graft rejection occurs due to?

A

occlusion of blood vessels and ischemia of organ

20
Q

which cells play an important role in triggering an acute rejection?

A

donor Dendritic cells

21
Q

can CD4 and CD8 contribute to graft rejection?

A

yes

22
Q

indirect allorecognition pathway contributes to which type of rejection?

A

acute

23
Q

Does Chronic rejection respond to immunosuppressive therapy?

A

no

24
Q

Fibrinopeptides lead to vascular permeability (vasodilation) that provide attractant of neutrophils and macrophages in the kinin cascade. Fibrinopeptides are a type of Non-immunological factor associated with?

A

allograft rejection

25
Q

a test used to test recipient serum for performed antibodies against donor HLAs is?

A

Cross-matching

26
Q

Corneal transplant, heart valve transplant, and bone/ tendon grafts are NOT important for?

A

ABO blood matching because of a barrier to transplantation

27
Q

The first step in donor transplantation is?

A

ABO compatibility because of its strong surface antigens on many tissues

28
Q

Universal donor blood?

A

type O

29
Q

complement is activated by classical pathway. patient of blood type A received type B blood. what happens?

A

RBC lysis because of anti-B antibodies on the surface of type A blood group.

30
Q

universal recipient?

A

AB blood

31
Q

to identify HLAs which test is preformed?

A

tissue typing

32
Q

success of transplantation is dependent on matching of?

A

MHC antigens

33
Q

the spleen and lymph node provide a convenient source of?

A

lymphocytes for HLA typing

34
Q

Microcytotoxicity test detects?

A

which Donors anti-serum to HLA antigens match the best with the recipient

35
Q

ABO is major antigen and Cross matching is Minor

A

…..

36
Q

a mixed lymphocyte reaction (MLR) is used in

A

class II HLA typing

37
Q

you want to determine if the donor cells stimulate proliferation of recipient lymphocytes. you use a?

A

a mixed lymphocyte reaction (MLR) in class II HLA typing

38
Q

Will proliferation occur in recipient tissue if the class II MHC antigens are different?

A

no. they MUST be the same for proliferation to occur

39
Q

in Graft vs. Host disease, T cells from the transplanted organ react how?

A

attack host tissue

40
Q

in host vs. graft disease. T cells from the host react how?

A

attack the transplanted organ

41
Q

T cells enter the allograft when endothelial cells are activated in

A

non-immune injury of the graft

42
Q

inability of the host immune system to reject allogenic cells due to the immunocompromised recipient causes?

A

Graft vs host disease.

43
Q

reaction directed against MINOR H antigens derived from polypmorphc proetin preented CD8……

A

Graft vs host disease

44
Q

The cornea is an immunologically

A

privileged site- free from the immune systems effects

immunology (12 decks)

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