Final exam-transplant immuno

Question 1

Autografts are?

Answer 1

exchanges from one part to another part of the same individual

Question 2

grafts exchanged between different individuals of identical constituites

Answer 2

isografts

Question 3

grafts exchanged between non-identical members of the same species

Answer 3

allograft

Question 4

grafts exchanged from members of different species

Answer 4

Xenograft

Question 5

HLA-antigens are

Answer 5

co-dominantly expressed

Question 6

strong barriers to transplantation are these antigens?

Answer 6

class I HLA-antigens (A and B)

Question 7

What are the most important for transplantation?

Answer 7

Class II- three types

HLA-DR, HLA-DP, HLA-DQ

Question 8

Direct allorecognition involves the T cell recognizing

Answer 8

unprocessed allogenic MHC molecules on graft APC’s

Question 9

Indirect allorecognition involves T cell recognizing

Answer 9

processed peptide of allogenic MHC molecules bound to self MHC molecules on host APC

Question 10

this type of rejection is caused by preformed antidonor antibodies and complement activated within minutes to hours

Answer 10

Hyperacute

Question 11

reactivation of sensitized T cells within days of transplant rejection

Answer 11

Accelerated

Question 12

primary activation of t cell in transplant rejection that takes days to weeks. involves cellular and vascular changes due to fibrosis

Answer 12

Acute rejection

Question 13

immunologic and non-immunologic factors that take months to years to reject a transplant

Answer 13

Chronic

Question 14

direct allorecognition pathway is the primary response to

Answer 14

graft transplant

Question 15

the indirect allorecognition pathway is most important in?

Answer 15

Chronic rejection

Question 16

Acute cellular involve the which T cells?

Answer 16

T helper 1

Question 17

Acute vascular humoral involve which T cells?

Answer 17

T helper 2

Question 18

after transplant, donor Dendritic cells migrate to?

Answer 18

lymph nodes

Question 19

Chronic graft rejection occurs due to?

Answer 19

occlusion of blood vessels and ischemia of organ

Question 20

which cells play an important role in triggering an acute rejection?

Answer 20

donor Dendritic cells

Question 21

can CD4 and CD8 contribute to graft rejection?

Answer 21

yes

Question 22

indirect allorecognition pathway contributes to which type of rejection?

Answer 22

acute

Question 23

Does Chronic rejection respond to immunosuppressive therapy?

Answer 23

no

Question 24

Fibrinopeptides lead to vascular permeability (vasodilation) that provide attractant of neutrophils and macrophages in the kinin cascade. Fibrinopeptides are a type of Non-immunological factor associated with?

Answer 24

allograft rejection

Question 25

a test used to test recipient serum for performed antibodies against donor HLAs is?

Answer 25

Cross-matching

Question 26

Corneal transplant, heart valve transplant, and bone/ tendon grafts are NOT important for?

Answer 26

ABO blood matching because of a barrier to transplantation

Question 27

The first step in donor transplantation is?

Answer 27

ABO compatibility because of its strong surface antigens on many tissues

Question 28

Universal donor blood?

Answer 28

type O

Question 29

complement is activated by classical pathway. patient of blood type A received type B blood. what happens?

Answer 29

RBC lysis because of anti-B antibodies on the surface of type A blood group.

Question 30

universal recipient?

Answer 30

AB blood

Question 31

to identify HLAs which test is preformed?

Answer 31

tissue typing

Question 32

success of transplantation is dependent on matching of?

Answer 32

MHC antigens

Question 33

the spleen and lymph node provide a convenient source of?

Answer 33

lymphocytes for HLA typing

Question 34

Microcytotoxicity test detects?

Answer 34

which Donors anti-serum to HLA antigens match the best with the recipient

Question 35

ABO is major antigen and Cross matching is Minor

Answer 35

.....

Question 36

a mixed lymphocyte reaction (MLR) is used in

Answer 36

class II HLA typing

Question 37

you want to determine if the donor cells stimulate proliferation of recipient lymphocytes. you use a?

Answer 37

a mixed lymphocyte reaction (MLR) in class II HLA typing

Question 38

Will proliferation occur in recipient tissue if the class II MHC antigens are different?

Answer 38

no. they MUST be the same for proliferation to occur

Question 39

in Graft vs. Host disease, T cells from the transplanted organ react how?

Answer 39

attack host tissue

Question 40

in host vs. graft disease. T cells from the host react how?

Answer 40

attack the transplanted organ

Question 41

T cells enter the allograft when endothelial cells are activated in

Answer 41

non-immune injury of the graft

Question 42

inability of the host immune system to reject allogenic cells due to the immunocompromised recipient causes?

Answer 42

Graft vs host disease.

Question 43

reaction directed against MINOR H antigens derived from polypmorphc proetin preented CD8......

Answer 43

Graft vs host disease

Question 44

The cornea is an immunologically

Answer 44

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