Differentiation and Functions of CD4+ T cells Flashcards
a/B TCR are MHC restricted. T/F?
true.
The a/B TCR recognizes (binds to) both peptides presented within
MHC molecules and MHC itself.
What do you need to activate a T cell?
TCR, CD4 or CD8, and CD3
CD3 proteins have long cytoplasmic tails long enough to?
signal transduce
Langerhans’ cells enter the Lymph node to become Dendritic cells expressing?
B7
B7- positive Dendritic cells stimulate which cell?
Naive T cells
Langerhans’ Cells are immature Dendritic cells that do not express high levels of B7 when they are?
not activated by antigens in the skin
Naive T cells do not have which receptor IL expressed on their surface?
IL-2R
activated T cells produce large amounts of IL-2 and EXPRESS?
IL-2Receptor
This Interleukin regulates T cell growth factor and enhances resistance of apoptosis in activated T cells.
IL-2
Tuberculosis (intracellular pathogen) causes the immune response of which lymphocyte, cytokine, and interleukin?
Th1, IFN-y, and IL-12
Th2 cells secrete which cytokines in helminthic and allergic reactions?
IL-4, IL-5, and IL-13
Th17 cells secrete which cytokines in extracellular and autoimmune inflammatory disease?
IL-17a, IL-17f, and IL-22
activated T cells by Dendritic cells that secrete IL-23 lead to activation of which cell in Neutrophilic or Monocytic inflammation
Th17
secretion of IFN-y by Th1 cells activate these cells which lead to this antibody production
Macrophages that lead to IgG production
IL-5 is the major cytokine in this reaction?
Allergy rxns and Helminth infections
Antibody mediated immune response is activated by which cell?
Th2 cells
Cell-mediated immune response is activated by which cells?
Th1
Th17 cells are involved in?
inflammation and anti-bacterial response
the outcome of Th0 (immature effector T cell) generates several of these subsets
Th1, Th2, and Th17
PRR-signaling causes activation and maturation of
APC
which interleukin assists the development and differentiation of Th1 cells?
IL-12
IL-12 is produced by?
DC and Macrophages
IFN-y produced by NK cells activate which transcription factors?
T-bet, STAT1, and STAT4
Transcription factors activated by IFN-y stimulate the differentiation of Naive CD4+ T cells to which subset?
Th1
IL-4 is produced by?
Th2 cells
IL-4 inhibits the development of Th1 and Th17 cells produced by?
Th2 cells
IL-4 activates which transcription factors
GATA 3 and STAT 6 which stimulate differentiation of naive CD4+ t cells to the Th2 subset
IL-23 is the most important cytokine in differentiation of which cells?
Th17 cells
IL-1, IL-6, and IL-23 activate the transcription factors
RORyt and STAT 3 to stimulate the differentiation of Th17 cells
Macrophages release ROS, NO upon activation of these cells in Cell mediated immunity?
Th1 cells
Tissue repair from Collateral damage induced by IL4 and IL13 by activated
Macrophages
IL-1, IL-12, and IL-23 are important interleukins for
Inflammatory response
IL-10 and TGF-beta are important mechanisms for
anti-inflammatory effects, wound repair, and fibrosis
Alternatively activated macrophages (M2) are stimulated in
Collateral damage and anti-inflammatory responses
Epithelial cells produce anti-microbial peptides stimulated by?
IL-17
