Differentiation and Functions of CD4+ T cells Flashcards
a/B TCR are MHC restricted. T/F?
true.
The a/B TCR recognizes (binds to) both peptides presented within
MHC molecules and MHC itself.
What do you need to activate a T cell?
TCR, CD4 or CD8, and CD3
CD3 proteins have long cytoplasmic tails long enough to?
signal transduce
Langerhans’ cells enter the Lymph node to become Dendritic cells expressing?
B7
B7- positive Dendritic cells stimulate which cell?
Naive T cells
Langerhans’ Cells are immature Dendritic cells that do not express high levels of B7 when they are?
not activated by antigens in the skin
Naive T cells do not have which receptor IL expressed on their surface?
IL-2R
activated T cells produce large amounts of IL-2 and EXPRESS?
IL-2Receptor
This Interleukin regulates T cell growth factor and enhances resistance of apoptosis in activated T cells.
IL-2
Tuberculosis (intracellular pathogen) causes the immune response of which lymphocyte, cytokine, and interleukin?
Th1, IFN-y, and IL-12
Th2 cells secrete which cytokines in helminthic and allergic reactions?
IL-4, IL-5, and IL-13
Th17 cells secrete which cytokines in extracellular and autoimmune inflammatory disease?
IL-17a, IL-17f, and IL-22
activated T cells by Dendritic cells that secrete IL-23 lead to activation of which cell in Neutrophilic or Monocytic inflammation
Th17
secretion of IFN-y by Th1 cells activate these cells which lead to this antibody production
Macrophages that lead to IgG production
IL-5 is the major cytokine in this reaction?
Allergy rxns and Helminth infections
Antibody mediated immune response is activated by which cell?
Th2 cells
Cell-mediated immune response is activated by which cells?
Th1
Th17 cells are involved in?
inflammation and anti-bacterial response
the outcome of Th0 (immature effector T cell) generates several of these subsets
Th1, Th2, and Th17
PRR-signaling causes activation and maturation of
APC
which interleukin assists the development and differentiation of Th1 cells?
IL-12
IL-12 is produced by?
DC and Macrophages
IFN-y produced by NK cells activate which transcription factors?
T-bet, STAT1, and STAT4
