effector mechanisms of humoral immunity

Question 0

A patient infected with Polio will express which mechanism of protective immunity?

Answer 0

neutralization of virus by mucosal IgA antibody

Question 1

What are the four effector functions of abs against microbes and their toxins?

Answer 1

neutralize antigen, opsonize them for phagocytosis, sensitize them for ab-dependent cellular cytotoxicity, and activate the complement system which are mediated by different Antibody isotypes

Question 2

opsonization and phagocytosis is mediated by which antibody?

Answer 2

IgM

Question 3

antibodies against microbes and their toxins do what for the body?

Answer 3

block binding of these microbes and their toxins to cellular receptors

Question 4

extreme levels of Tissue Necrosis Factor from Endotoxin LPS, causes a condition known as?

Answer 4

Cytokine Storm. from overwhelming amount of cytokines produced and system organ failure and eventually death.

Question 5

which isotypes are the most efficient opsonins for promoting phagocytosis via the high affinity FcyR1 (CD64)?

Answer 5

IgG1 and IgG3

Question 6

FcyRIIB receptor is a type of?

Answer 6

Inhibitory signal

Question 7

SHIP converts ___ to block B cell receptor signaling to inhibit activation?

Answer 7

PIP3 to PIP2 upon FcyRIIB binding

Question 8

Perforin and Granzyme recruit?

Answer 8

Caspase 3 which induces cell death cascade

Question 9

Helminthic worms can be killed by a toxic cationic protein, known as?…present in eosinophil granules

Answer 9

Major Basic Protein

Question 10

IgE that coat helminths can bind to FceRI on eosinphils to cause?

Answer 10

degranulation to release major basic protein