final exam- hypersensitivity Flashcards
immune complex diseases is this type of hypersensitivty
type III
T cell mediated disease like Type I DM is this type of hypersensitivity?
Type IV hypersensitivity
type of pathologic reactions that is caused by the release of mediators (histamine) from mast cells
Immediate type I hypersensitivity
immediate type I produced this antibody against environmental ags
IgE
the genetic tendency to develop allergic diseases
atopy
activation of Th2 and IgE in response to ag allergens
type I hypersensitivity
two phases of Hypersensitivity. 1. histamine reacts in an? cytokines react in?
- immediate hypersensitivity reaction
2. late phase
prolonged smooth muscle contraction is stimulated by?
leukotrienes
the hallmarks of immediate hypersensitivity are?
mast cell mediators, acute vascular dilation and smooth muscle contraction.
in type II hypersensitivity, which antibodies activate the complement system by the classical pathway?
IgG and IgM
IgG abs bind to neutrophil and macrophage Fc receptors and activate these leukocytes resulting in?
pro-inflammatory response
C5a is a major?
chemoattractant
Graves disease, Rheumatic fever, Pemphigus vulgaris, ITP, Goodpastures syndrome, and Autoimmuno hemolytic anemia, are all types of ?
type II hypersensitivity
immune complexes induce vascular inflammation, ischemic damage to the tissues in this type of hypersensitivity
Type III
34 yr male comes to the ER with a venomous snake bite to the forearm. patient received Cro-fab, an anti-venom serum. Soon after administration, patient developed systemic vasculitis, nephritis, and arthritis. This best describes what type of hypersensitivity disease?
Serum sickness in a type III hypersensitivity disease
in different T cell mediated disease, tissue injury is caused by inflammation induced by cytokines that are produced mainly by?
CD4+ Th1 cells and Th 17 cells.
Multiple sclerosis, RA, TIDM, Crohn’s disease, contact dermatitis, and chronic infections like Tuberculosis are diseases of this type of hypersensitivity?
Type IV
humans may be sensitized for this type of reactions by microbial infection (TB) by contact sensitization (poison ivy) or immunization (Diphtheria and Tetanus toxoid)
Delayed Type Hyper-sensitization by the activation of CD4+ T cells
the tuberculin subcutaneous injection elicits a ____ from a purified protein derivative dependent on concentration of antigen
Delayed Type hypersensitivity
exposure to Tuberculosis activates which cell? ….
CD4+ Th1 T cells …..
Principles of Immunotherapy
IVIG, anti-TNF antibody, corticosteroids, depletion of CD20 antibody for B cells
the common subunit for IL-12 and IL-23 is?
P40. anti P40 blocks Th1 and Th 17 responses
Anti-IL17 blocks?
inflammation
Anti IL-2R blocks?
T cell proliferation
CTLA4Ig blocks
costimulation
SLE is a type __ hypersensitivity
Type III-prototypic immune complex mediated disease
*lecture slides are wrong. NOT TYPE II
the principal diagnostic test for SLE is the presence of?
persistent high level anti-nuclear IgG antibody production
Rheumatoid Arthritis mediated by?
mixed type II and III hypersensitivity reactions to the synovial joints patients have circulating IgM or IgG that react with the Fc on their own IgG molecules.
what is a major diagnostic factor for RA?
auto-abs called Rheumatoid Factors
in pathogenesis of MS, demyelination of oligodendrocytes are caused from?
excess Glutamate
major mechanism involved in Type I DM is?
type IV cell mediated by autoantibodies
inflammatory bowel disease is linked to
microflora in the gut
clinical manifestations of immediate type I hypersensitivity result from actions of mediators secreted by the
Mast cells
