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immunology > final exam- hypersensitivity > Flashcards

final exam- hypersensitivity Flashcards

1
Q

immune complex diseases is this type of hypersensitivty

A

type III

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2
Q

T cell mediated disease like Type I DM is this type of hypersensitivity?

A

Type IV hypersensitivity

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3
Q

type of pathologic reactions that is caused by the release of mediators (histamine) from mast cells

A

Immediate type I hypersensitivity

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4
Q

immediate type I produced this antibody against environmental ags

A

IgE

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5
Q

the genetic tendency to develop allergic diseases

A

atopy

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6
Q

activation of Th2 and IgE in response to ag allergens

A

type I hypersensitivity

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7
Q

two phases of Hypersensitivity. 1. histamine reacts in an? cytokines react in?

A
  1. immediate hypersensitivity reaction

2. late phase

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8
Q

prolonged smooth muscle contraction is stimulated by?

A

leukotrienes

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9
Q

the hallmarks of immediate hypersensitivity are?

A

mast cell mediators, acute vascular dilation and smooth muscle contraction.

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10
Q

in type II hypersensitivity, which antibodies activate the complement system by the classical pathway?

A

IgG and IgM

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11
Q

IgG abs bind to neutrophil and macrophage Fc receptors and activate these leukocytes resulting in?

A

pro-inflammatory response

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12
Q

C5a is a major?

A

chemoattractant

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13
Q

Graves disease, Rheumatic fever, Pemphigus vulgaris, ITP, Goodpastures syndrome, and Autoimmuno hemolytic anemia, are all types of ?

A

type II hypersensitivity

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14
Q

immune complexes induce vascular inflammation, ischemic damage to the tissues in this type of hypersensitivity

A

Type III

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15
Q

34 yr male comes to the ER with a venomous snake bite to the forearm. patient received Cro-fab, an anti-venom serum. Soon after administration, patient developed systemic vasculitis, nephritis, and arthritis. This best describes what type of hypersensitivity disease?

A

Serum sickness in a type III hypersensitivity disease

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16
Q

in different T cell mediated disease, tissue injury is caused by inflammation induced by cytokines that are produced mainly by?

A

CD4+ Th1 cells and Th 17 cells.

17
Q

Multiple sclerosis, RA, TIDM, Crohn’s disease, contact dermatitis, and chronic infections like Tuberculosis are diseases of this type of hypersensitivity?

A

Type IV

18
Q

humans may be sensitized for this type of reactions by microbial infection (TB) by contact sensitization (poison ivy) or immunization (Diphtheria and Tetanus toxoid)

A

Delayed Type Hyper-sensitization by the activation of CD4+ T cells

19
Q

the tuberculin subcutaneous injection elicits a ____ from a purified protein derivative dependent on concentration of antigen

A

Delayed Type hypersensitivity

20
Q

exposure to Tuberculosis activates which cell? ….

A

CD4+ Th1 T cells …..

21
Q

Principles of Immunotherapy

A

IVIG, anti-TNF antibody, corticosteroids, depletion of CD20 antibody for B cells

22
Q

the common subunit for IL-12 and IL-23 is?

A

P40. anti P40 blocks Th1 and Th 17 responses

23
Q

Anti-IL17 blocks?

A

inflammation

24
Q

Anti IL-2R blocks?

A

T cell proliferation

25
Q

CTLA4Ig blocks

A

costimulation

26
Q

SLE is a type __ hypersensitivity

A

Type III-prototypic immune complex mediated disease

*lecture slides are wrong. NOT TYPE II

27
Q

the principal diagnostic test for SLE is the presence of?

A

persistent high level anti-nuclear IgG antibody production

28
Q

Rheumatoid Arthritis mediated by?

A

mixed type II and III hypersensitivity reactions to the synovial joints patients have circulating IgM or IgG that react with the Fc on their own IgG molecules.

29
Q

what is a major diagnostic factor for RA?

A

auto-abs called Rheumatoid Factors

30
Q

in pathogenesis of MS, demyelination of oligodendrocytes are caused from?

A

excess Glutamate

31
Q

major mechanism involved in Type I DM is?

A

type IV cell mediated by autoantibodies

32
Q

inflammatory bowel disease is linked to

A

microflora in the gut

33
Q

clinical manifestations of immediate type I hypersensitivity result from actions of mediators secreted by the

A

Mast cells

immunology (12 decks)

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