Final Exam Info Bio 322 Flashcards
The cephalic phase of pancreatic secretion is stimulated and has the same mechanism as the cephalic phase of gastric acid secretion.
a. True
b. False
a. True
Which cholinergic receptor is found on chief cells?
M3 muscarinic receptor
Activation of pancreatic acinar secretagogue receptors leads to phosphorylation and increased permeability of which two channels?
apical Cl- leak channel
basolateral K+ leak channel
What is the primary stimulus for secretin secretion?
Gastric acid in duodenum
What is the primary stimulus for cholecystokinin secretion?
lipids and peptones in duodenum
Which nerve innervates each of the salivary glands?
sublingual and submandibular salivary glands-facial nerve
parotid salivary gland-glossopharyngeal nerve
What four digestive enzymes or types of enzymes are produced by the pancreas?
Proteases, Amylases, Lipase, Nucleases
What are the two secretagogues for salivary alveolar cell fluid secretion and what receptor does each act on? Which one is the primary secretagogue?
Acetylcholine on M3 muscarinic receptor (Gq)-primary
epinephrine on alpha-1 adrenergic receptor (Gq)
State three endogenous chemicals that can stimulate bicarbonate ion secretion into the mucus layer of the stomach.
Acetylcholine
acid (main one)
prostaglandins
State four endogenous chemicals that can stimulate mucus secretion in the stomach.
Acetylcholine acid (main one) prostaglandins pepsin bile acid
What are the two primary purposes of the fluid secreted by the pancreatic duct cells?
- helps neutralize stomach acid entering duodenum
2. provides fluid pressure for bulk flow of the enzymes into the duodenum
What are the three phases of pancreatic secretion in response to a meal, and about what percent of the total enzyme secreted in response to a meal is released in each phase?
- cephalic-25%
- gastric-10-20%
- intestinal-50-80%
What are the four primary purposes of saliva?
- Prevent dehydration of oral mucosa
- Lubrication for mastication and swallowing
- Assist in maintaining oral hygiene
- Taste-dissolving substances for taste
What is a zymogen?
an inactive digestive enzyme precursor
List all the ways prostaglandins act to protect the stomach and duodenum from damage due to acid.
- Inhibit acid secretion directly and inhibiting gastrin and histamine
- Stimulate mucus secretion in the stomach
- Stimulate bicarb release in the stomach and duodenum
Fill in the table for the two primary secretagogues for pancreatic acinar cells.
Do on a separate sheet of paper
Fill in the table for the two primary secretagogues for pancreatic ducts cells.
Do on a separate sheet of paper.
Draw a flow chart for fluid secretion by pancreatic acini.
Do on a separate sheet of paper.
Draw a flow chart for fluid secretion by pancreatic ducts.
Do on a separate sheet of paper.
Proteases are always released from cells as zymogens.
a. True
b. False
a. True
Pepsin can catalyze its own production.
a. True
b. False
a. True
Pepsin can create individual amino acids.
a. True
b. False
b. False
The exocrine function of the pancreas involves the
a. acini
b. islets
a. acini
Digestive enzymes are released by _________________ cells in the pancreas.
a. acinar
b. duct
c. both acinar and duct
a. acinar
Which cells produce cholecystokinin?
a. D cells
b. G cells
c. I cells
d. S cells
c. I cells
Which cells produce secretin?
a. D cells
b. G cells
c. I cells
d. S cells
d. S cells
The gastric phase of pancreatic secretion is primarily dependent on
a. acetylcholine
b. cholecystokinin
c. gastrin
d. secretin
a. acetylcholine
Saliva is __________-tonic
a. hyper
b. hypo
c. iso
b. hypo
Which branch of the nervous system is the primary regulator of salivation?
a. parasympathetic
b. sympathetic
c. somatic
a. parasympathetic
More fluid is secreted by pancreatic
a. acinar cells
b. duct cells
b. duct cells
You can remove 80% of the pancreas and still have normal digestion.
a. True
b. False
a. True
Secretion of fluid in salivary alveolar cells involves the same mechanisms as in pancreatic acinar cells.
a. True
b. False
a. True
Salivary alveolar cells secrete an isotonic saline.
a. True
b. False
a. True
Saliva contains more
a. Sodium and chloride
b. Potassium and bicarbonate
b. Potassium and bicarbonate
The sympathetic nervous system tends to decrease salivation.
a. True
b. False
b. False
Water and electrolytes are absorbed in both the small and large intestine.
a. True
b. False
a. True
Water is actively absorbed out of the intestines.
a. True
b. False
b. False
Which chemical is the primary regulator of pancreatic duct cells?
a. secretin
b. cholecystokinin
c. substance P
d. acetylcholine
e. gastrin
a. secretin
What is the primary stimulator of chief cells?
a. norepinephrine
b. gastrin
c. histamine
d. epinephrine
e. acetylcholine
e. acetylcholine
Pepsin only becomes active in the stomach when the pH is less than
a. 1
b. 1.5
c. 3
d. 4
e. 2
f. 4.5
g. 5
h. 3.5
i. 2.5
h. 3.5
Pepsinogen can spontaneously breakdown into pepsin when the pH is less than
a. 3
b. 2
c. 4
d. 3.5
e. 5
f. 1.5
g. 2.5
h. 4.5
i. 1
e. 5
Match the salivary gland with its type of secretion.
a. parotid salivary gland
b. sublingual salivary gland
c. submandibular salivary gland
choices: serous, mucinous, mixed
a. serous
b. mucinous
c. mixed
Aldosterone increases sodium absorption in the gut.
a. True
b. False
a. True
Fiber is an important source of energy in humans.
a. True
b. False
b. False
Which enzyme is NOT normally expressed in adult animals?
a. glucoamylase
b. isomaltase
c. lactase
d. sucrase
c. lactase
The transport of glucose and galactose across the apical membrane of enterocytes is
a. active
b. passive
a. active
Absorption of peptones across the apical membrane of enterocytes is
a. active
b. passive
a. active
Absorption of amino acids across the basolateral membrane of enterocytes is
a. active
b. passive
b. passive
There are peptidases on the brush border and in the intracellular space of enterocytes.
a. True
b. False
a. True
There are brush border enzymes for the digestion of fats.
a. True
b. False
b. False
Colipase is an enzyme.
a. True
b. False
b. False
Monoglycerides and free fatty acids are transported in chylomicrons out of the enterocyte.
a. True
b. False
b. False
Fats are absorbed into the villous capillaries of the small intestine.
a. True
b. False
b. False
The transport of fructose across the apical membrane of enterocytes is
a. active
b. passive
b. passive
The transport of monosaccharides across the basolateral membrane of enterocytes is
a. active
b. passive
b. passive
Excess amino acids in our diet are converted to glucose.
a. True
b. False
a. True
Excess fatty acids in our diet are converted to glucose.
a. True
b. False
b. False
Oligopeptides can be transported across the apical membrane of enterocytes.
a. True
b. False
a. True
Chloride absorption is closely linked with sodium absorption in the intestines.
a. True
b. False
a. True
Most chemical digestion occurs in the
a. large intestine
b. mouth
c. small intestine
d. stomach
c. small intestine
In the post-prandial period, the absorption of sodium in the small intestine is primarily through
a. ENaC
b. Nutrient cotransport
c. Parallel sodium-hydrogen exchange and chloride-bicarbonate ion exchange
d. Sodium-hydrogen exchange alone
b. Nutrient cotransport
Which of the following are electrogenic sodium absorption processes? (Select all that apply)
a. ENaC
b. Nutrient cotransport
c. Parallel sodium-hydrogen exchange and chloride-bicarbonate ion exchange
d. Sodium-hydrogen exchange alone
a. ENaC
b. Nutrient cotransport
In the interdigestive period, the absorption of sodium in the small intestine is primarily through
a. ENaC
b. Nutrient cotransport
c. Parallel sodium-hydrogen exchange and chloride-bicarbonate ion exchange
d. Sodium-hydrogen exchange alone
c. Parallel sodium-hydrogen exchange and chloride-bicarbonate ion exchange
All nutrients absorbed from the intestines other than fat go to the liver before entering general circulation.
a. True
b. False
a. True
There are no absorptive process for the macronutrients in the large intestine.
a. True
b. False
a. True
Amylase can break (select all that apply)
a. Terminal α-1,4 glucose linkages
b. α-1,4 glucose linkages adjacent to α-1,6 glucose linkages
c. α-1,4 glucose linkages adjacent to other α-1,4 glucose linkages
d. α-1,6 glucose linkages
c. α-1,4 glucose linkages adjacent to other α-1,4 glucose linkages
Glucoamylase can break (select all that apply)
a. Terminal α-1,4 glucose linkages
b. α-1,4 glucose linkages adjacent to α-1,6 glucose linkages
c. α-1,4 glucose linkages adjacent to other α-1,4 glucose linkages
d. α-1,6 glucose linkages
a. Terminal α-1,4 glucose linkages
Isomaltase can break (select all that apply)
a. Terminal α-1,4 glucose linkages
b. α-1,4 glucose linkages adjacent to α-1,6 glucose linkages
c. α-1,4 glucose linkages adjacent to other α-1,4 glucose linkages
d. α-1,6 glucose linkages
a. Terminal α-1,4 glucose linkages
b. α-1,4 glucose linkages adjacent to α-1,6 glucose linkages
c. α-1,4 glucose linkages adjacent to other α-1,4 glucose linkages
d. α-1,6 glucose linkages
Which of the following can generate individual amino acids? (select all that apply)
a. Brush border peptidases
b. Carboxypeptidase
c. Chymotrypsin
d. Intracellular peptidases
e. Pepsin
f. Trypsin
a. Brush border peptidases
b. Carboxypeptidase
d. Intracellular peptidases
Bile salts can __________________ fats, which means to create very small droplets of fat coated in water.
emulsify
What protein transports sodium across the basolateral membrane of enterocytes?
Na+/K+ pump
Starch is a polymer of what monosaccharide?
Glucose
What protein transports glucose and galactose across the apical membrane of enterocytes?
SGLT1
Which is the largest water-soluble vitamin humans need?
Vitamin B12
What protein transports fructose across the apical membrane of enterocytes?
GLUT5
What protein transports monosaccharides across the basolateral membrane of enterocytes?
GLUT2
What protein helps increase the rate of fat digestion by holding lipase near a fat droplet?
colipase
How do monoglycerine and free fatty acids get across the apical membrane of enterocytes?
simple diffusion
What two monosaccharides form sucrose?
glucose and fructose
What two monosaccharides form lactose?
galactose and glucose
What are the three products of amylopectin digestion by amylase?
- maltose
- maltotriose
- alpha-limited dextrins
What are the three pancreatic peptidases?
- trypsin
- chymotrypsin
- carboxypeptidase
What are three components of chylomicrons?
- triglycerides
- phospholipids
- proteins