Exam 4 Bio 322 Flashcards
_____________ and anything in the plasma bound to them, will not be filtered into Bowman’s capsule.
dProteins
Approximately what percentage of the carbon dioxide produced by cells stays in the blood as dissolved carbon dioxide?
10%
Approximately what percent of the carbon dioxide produced by cells bind to hemoglobin in the blood?
30%
What name is given to hemoglobin that has carbon dioxide bound to it?
carbaminohemoglobin
What is normal body pH?
7.40
What is venous blood pH?
7.36
Approximately how much of the plasma that enters a glomerulus is usually filtered into Bowman’s capsule?
20%
What protein buffers blood pH by binding to hydrogen ions?
deoxyhemoglobin
Where, specifically, do you find the rhythm-generation neurons for respiration?
Pre-Botzinger complex in the ventral respiratory group
What organ makes DPG and what stimulates its release into the blood?
Kidney-low oxygen delivery to the kidney
What are the names of the areas in the pons that regulate breathing?
pneumotaxic center
apneustic center
Where, specifically, do you find the peripheral chemoreceptors?
Carotid bodies
Aortic arch
Peripheral chemoreceptors are directly sensitive to which two chemicals in the blood?
- O2
2. H+
What effect do the pontine respiratory regions have on breathing?
They smooth the transition between inspiration and expiration
What three variables determine the glomerular filtration rate?
- Net filtration pressure
- Permeability of the corpuscular membranes
- surface area available for filtration
What is the equation for renal excretion based on the three basic renal processes?
Amount of substance excreted in the urine=Amount filtered + Amount secreted - amount absorbed
What happens to the carbon dioxide produced by cells and transported in the blood that does not stay dissolved or bound to hemoglobin? Draw the reaction and dissociation that occurs and include the enzyme that is involved.
It is converted to carbonic acid which dissociates into H+ and bicarbonate (HCO3-)
What happens in the chloride shift in red blood cells?
Bicarbonate is exchanged for Cl- across the red blood cell plasma membrane
What are the five functions of the kidney that were mentioned in the video?
- Regulation of water and ion balance
- Removal of metabolic waste products from the blood
- Removal of foreign chemicals
- Gluconeogenesis
- Production of hormones/enzymes
What is the mechanism of action and effect of mesangial cells in the kidney?
Mesangial cells close off glomeruli to decrease the surface area available for filtration thus decreasing glomerular filtration.
Given the following,
Glomerular filtration rate=130 ml/min
Plasma sodium concentration= 150 mM
Urine collection time= 1 hour
Urine sodium concentration= 20 mM
Urine volume collected=60 ml
a. What is the filtered load of sodium?
b. What is the excretion rate of sodium c. Is sodium netly secreted, netly reabsorbed or neither?
a. 19.5 mmol/min
b. 20 umol/min
c. Netly reabsorbed
Hemoglobin has ___________ affinity for oxygen in the pulmonary capillaries versus the systemic capillaries
a. a higher
b. a lower
c. the same
a. a higher
Carbonic anhydrase is found
a. both in red blood cells and in the plasma
b. in red blood cells but not the plasma
c. in the plasma but not in red blood cells
b. in red blood cells but not the plasma
Carbon dioxide binds covalently to hemoglobin.
a. True
b. False
b. False
Hyperventilation leads to
a. respiratory acidosis
b. respiratory alkalosis
b. respiratory alkalosis
Inspiratory neurons are found in the
a. dorsal respiratory group
b. ventral respiratory group
c. both the dorsal and ventral respiratory groups
c. both the dorsal and ventral respiratory groups
Expiratory neurons are found in the
a. dorsal respiratory group
b. ventral respiratory group
c. both the dorsal and ventral respiratory groups
b. ventral respiratory group
Lung stretch receptors are important regulators of breath depth at rest.
a. True
b. False
b. False
Central chemoreceptors respond (directly or indirectly) to changes in which arterial blood chemicals?
a. carbon dioxide
b. metabolic acids
c. oxygen
a. carbon dioxide
What is the primary organ to do gluconeogenesis in the body?
a. lung
b. kidney
c. liver
d. spleen
c. liver
The fenestrae in glomerular capillaries are _______________ in most other capillary beds.
a. larger than
b. smaller than
c. the same size as
a. larger than
As plasma flows through the glomerular capillary there is the largest
a. decrease in hydrostatic pressure
b. decrease in oncotic pressure
c. increase in hydrostatic pressure
d. increase in oncotic pressure
d. increase in oncotic pressure
Net filtration pressure at the end of the glomerular capillary is usually
a. negative
b. positive
c. zero
c. zero
The entire plasma volume is normally filtered in the kidney
a. once every two hours
b. once every hour
c. 60 times per day
d. 125 times per day
c. 60 times per day
Which of the following would tend to increase glomerular filtration rate? (select all that apply)
a. Afferent arteriole vasoconstriction
b. Afferent arteriole vasodilation
c. Efferent arteriole vasoconstriction
d. Efferent arteriole vasodilation
b. Afferent arteriole vasodilation
c. Efferent arteriole vasoconstriction
Changing the level of smooth muscle activity in the afferent and/or efferent arterioles
a. Changes corpuscular membrane permeability
b. Changes the surface area available for filtration
c. Changes glomerular hydrostatic pressure
d. Changes glomerular oncotic pressure
c. Changes glomerular hydrostatic pressure
In healthy people, the renal excretion of glucose varies with glucose intake.
a. True
b. False
b. False
In non-regulated reabsorption, usually ____________________ of a filtered substance gets reabsorbed in the nephron.
a. a set percentage
b. a variable amount
c. all
d. none
c. all
In individuals on a very low carbohydrate, high fat (ketogenic) diet the liver produces ketones, which enter the blood. Ketones are acidic. You would expect someone on a ketogenic diet to have _____________________arterial PCO2 compared to individuals on a standard American diet.
a. a lower
b. the same
c. a higher
a. a lower
The primary determinate of hemoglobin saturation is
a. The temperature
b. The PCO2
c. the pH
d. The PO2
e. the concentration of DPG
d. The PO2
Which of the following would increase the affinity of hemoglobin for oxygen? (select all that apply)
a. None of these would increase the affinity of hemoglobin for oxygen
b. Increasing the PCO2
c. Increasing the pH
d. Increasing the concentration of DPG
e. Increasing the temperature
c. Increasing the pH
Which of the following values is/are zero in healthy individuals? (select all that apply)
a. oncotic pressure in Bowman’s capsule
b. hydrostatic pressure in the glomerulus
c. oncotic pressure in the glomerulus
d. hydrostatic pressure in Bowman’s capsule
e. none of these values should be zero
a. oncotic pressure in Bowman’s capsule
Sodium is NOT reabsorbed in (select all that apply)
a. The ascending loop of Henle
b. The cortical collecting ducts
c. The descending loop of Henle
d. The distal convoluted tubule
e. The medullary collecting ducts
f. The proximal convoluted tubule
c. The descending loop of Henle
e. The medullary collecting ducts
Most water-soluble vitamins
a. Are not filtered in the kidney
b. Are filtered in the kidney and reabsorbed by transporters
c. Are filtered in the kidney and reabsorbed by channels
d. Are filtered in the kidney and reabsorbed by simple diffusion through the tubular
membranes
e. Are filtered in the kidney and not reabsorbed
b. Are filtered in the kidney and reabsorbed by transporters
The reabsorption of many substances in the kidney is tied to the reabsorption of what ion?
Sodium
The secretion of many substances in the kidney is tied to the reabsorption of what ion?
Sodium
If a substance in freely filtered in the renal corpuscle, and its concentration in the afferent arteriole is 45 mg/ml, what is its concentration in the efferent arteriole?
45 mg/mL
Substance X is freely-filtered, not secreted, and not reabsorbed. Given the following
information, what is the clearance of substance X? If not enough information is given to
determine the clearance, state that, and state what other value(s) you would need to know.
Glomerular filtration rate = 145 ml/min
Plasma concentration of substance X = 2 mg/ml
Urine flow rate = 200 ml/hour
145 ml/min
Substance Y is freely-filtered. Given the following information, what is the clearance of substance Y? If not enough information is given to determine the clearance, state that, and state what other value(s) you would need to know.
Glomerular filtration rate = 145 ml/min
Plasma concentration of substance Y = 2 mg/ml
Time for urine collection = 2 hours
Urine concentration of substance Y = 20 mg/ml
Urine volume collected = 240 ml
20 mL/min
There is ______________________ of substance Y.
a. net reabsorption
b. net secretion
c. Neither net reabsorption nor net secretion
a. net reabsorption
What nerve carries post-ganglionic sympathetic axons toward the urinary bladder/urinary sphincters?
hypogastric nerve
What nerve carries pre-ganglionic parasympathetic axons toward the urinary bladder/urinary sphincters?
pelvic nerve
What nerve carries alpha motor neuron axons toward the urinary bladder/urinary sphincters?
pudendal nerve
What receptor for the sympathetic nervous system/circulating epinephrine is present on the internal urinary sphincter, and what type of receptor is it?
alpha-1 adrenergic, Gq-protein-coupled receptor
What receptor for the sympathetic nervous system/circulating epinephrine is present on the detrusor muscle, and what type of receptor is it?
Beta-2 adrenergic, Gs-protein coupled receptor
What nerve carries urinary bladder stretch receptor afferents to the spinal cord?
pelvic nerve
What receptor for the parasympathetic nervous system is present on the internal urinary sphincter, and what type of receptor is it?
M2 muscarinic receptor, Gi-protein-coupled receptor
What receptor for the parasympathetic nervous system is present on the detrusor muscle, and what type of receptor is it?
M3 muscarinic Gq-protein-coupled receptor
The micturition reflex cannot be consciously controlled until children are about how old?
2 years old
What is the name of the channel for sodium in the apical membrane of distal convoluted tubular cells?
ENaC
What are the three substances normally excreted from the body that contain sodium? Which substance has the greatest variation in the amount of sodium excreted based on the needs of the body?
- Sweat
- Urine (most variablility)
- Feces
What are the four locations where water is normally lost from the body, and which location(s) are regulated to control total body water?
- Skin
- Respiratory airways
- Gastrointestinal tract
- Urinary tract (where water balance is)
What are four conditions mentioned in the video that can lead to greater than normal sodium and water loss?
- Severe sweating
- Vomiting
- Diarrhea
- hemorrhage
What is the physiological definition of clearance?
The volume of plasma completely cleared of a particular substance per unit time
How does a concentration gradient for diffusion develop between the proximal convoluted tubule and the peritubular capillaries for a substance that is freely filtered?
As water is reabsorbed in the proximal convoluted tubules, the concentration of the solutes in the tubule increases and the concentration in the blood decreases, creating a diffusion gradient for the substance to be reabsorbed.
Why would you see glucose in the urine before the renal transport maximum for glucose is reached?
Not all nephrons have the same number of glucose transporters. When you reach the transport maximum for the nephron with the fewest transporters, you will start seeing glucose in the urine. You do not reach the transport maximum for the whole kidney until the nephron with the most transporters is saturated.
All epithelial cells have the sodium-potassium pump in
a. Their basolateral membrane
b. Their apical membrane
c. Both their apical and basolateral membrane
d. It varies by epithelial cell
a. Their basolateral membrane
In non-regulated reabsorption, the substance
a. would never appear in the urine
b. would always appear in the urine
c. may appear in the urine if the blood concentration is high enough
c. may appear in the urine if the blood concentration is high enough
It is easier to consume toxic levels of most water-soluble vitamins than most fat-soluble vitamins.
a. True
b. False
b. False
The renal clearance of all freely-filtered substances equals the glomerular filtration rate.
a. True
b. False
b. False
The clearance of creatinine is
a. Equal to the glomerular filtration rate
b. Greater than the glomerular filtration rate
c. Less than the glomerular filtration rate
b. Greater than the glomerular filtration rate
The sympathetic nervous system innervates the (select all that apply)
a. detrusor muscle
b. external urinary sphincter
c. internal urinary sphincter
c. internal urinary sphincter
The parasympathetic nervous system innervates the (select all that apply)
a. detrusor muscle
b. external urinary sphincter
c. internal urinary sphincter
a. detrusor muscle
c. internal urinary sphincter
The somatic nervous system innervates the (select all that apply)
a. detrusor muscle
b. external urinary sphincter
c. internal urinary sphincter
b. external urinary sphincter
Activation of the _______________________ nervous system leads to micturition
a. parasympathetic
b. somatic
c. sympathetic
a. parasympathetic
Increasing sodium consumption significantly increases blood pressure in most people.
a. True
b. False
b. False
Contraction of the detrusor muscle
a. Increases urinary bladder compliance and pressure
b. Decreases urinary bladder compliance and pressure
c. Increases urinary bladder compliance and decreases pressure
d. Decreases urinary bladder compliance and increases pressure
d. Decreases urinary bladder compliance and increases pressure
Water is actively reabsorbed in the kidney.
a. True
b. False
b. False
How sodium gets across the apical membrane of kidney tubular cells varies depending on the segment of the tubule.
a. True
b. False
a. True
As sodium is reabsorbed, the osmolarity of the tubule
a. decreases and the blood increases
b. increases and the blood decreases
a. decreases and the blood increases
Excessive water consumption during exercise or mental stress can lead to death by
a. hypokalemia
b. hypernatremia
c. hypocalcemia
d. hyponatremia
e. hyperkalemia
f. hypercalcemia
d. hyponatremia
The urinary bladder stretch receptor afferent neuron is
a. gabaergic
b. sertonergic
c. dopaminergic
d. adrenergic
e. cholinergic
f. glycinergic
g. glutamatergic
g. glutamatergic
Activation of the urinary bladder stretch receptor and micturition center leads to (select all that apply)
a. Activation of the somatic nervous system to the urinary bladder/urinary sphincters
b. Activation of the parasympathetic nervous system to the urinary bladder/urinary sphincters
c. Inactivation of the somatic nervous system to the urinary bladder/urinary sphincters
d. Inactivation of the sympathetic nervous system to the urinary bladder/urinary sphincters
e. Activation of the sympathetic nervous system to the urinary bladder/urinary sphincters
f. Inactivation of the parasympathetic nervous system to the urinary bladder/urinary sphincters
b. Activation of the parasympathetic nervous system to the urinary bladder/urinary sphincters
c. Inactivation of the somatic nervous system to the urinary bladder/urinary sphincters
d. Inactivation of the sympathetic nervous system to the urinary bladder/urinary sphincters
Activation of the urinary bladder stretch receptor directly leads to (select all that apply)
a. Inactivation of the somatic nervous system to the urinary bladder/urinary sphincters
b. Activation of the parasympathetic nervous system to the urinary bladder/urinary sphincters
c. Inactivation of the parasympathetic nervous system to the urinary bladder/urinary sphincters
d. Inactivation of the sympathetic nervous system to the urinary bladder/urinary sphincters
e. Activation of the sympathetic nervous system to the urinary bladder/urinary sphincters
f. Activation of the somatic nervous system to the urinary bladder/urinary sphincters
b. Activation of the parasympathetic nervous system to the urinary bladder/urinary sphincters
If a substance in freely filtered in the renal corpuscle, and its concentration in the afferent arteriole is 35 mg/ml, what is its concentration in Bowman’s capsule in mg/ml?
35 mg/ml
The countercurrent systems in the kidney can create an interstitium osmolarity of up to about
a. 300 mOsm
b. 700 mOsm
c. 1400 mOsm
d. 2000 mOsm
b. 700 mOsm
When more water is reabsorbed in the medullary collecting duct
a. less sodium is reabsorbed
b. less urea is reabsorbed
c. more sodium is reabsorbed
d. more urea is reabsorbed
d. more urea is reabsorbed
In the kidney, sodium is (select all that apply)
a. freely filtered
b. reabsorbed
c. secreted
a. freely filtered
b. reabsorbed
Normally, ___________ of the sodium filtered is excreted in the urine.
a. a variable amount
b. all
c. none
a. a variable amount
The sympathetic nervous system causes (select all that apply)
a. Afferent arteriole vasoconstriction
b. Afferent arteriole vasodilation
c. Efferent arteriole vasoconstriction
d. Efferent arteriole vasodilation
a. Afferent arteriole vasoconstriction
Atrial natriuretic factor causes (select all that apply)
a. Afferent arteriole vasoconstriction
b. Afferent arteriole vasodilation
c. Efferent arteriole vasoconstriction
d. Efferent arteriole vasodilation
b. Afferent arteriole vasodilation
c. Efferent arteriole vasoconstriction
Which adrenergic receptor is present on renal arteriolar smooth muscle?
a. α1
b. α2
c. β1
d. β2
a. α1
Activation of the sympathetic nervous system to the kidney ___________________ glomerular filtration rate.
a. decreases
b. does not affect
c. increases
a. decreases
Decreasing mean arterial pressure decreases hydrostatic pressure in the glomerulus.
a. True
b. False
a. True
Atrial natriuretic factor stimulates aldosterone production.
a. True
b. False
b. False
Atrial natriuretic factor is not usually important in regulating sodium in the body of healthy people.
a. True
b. False
a. True