Final Exam 2 Flashcards
Tight junctions
Outer layers of the plasma membranes between two cells are fused
Creates a fluid tight seal
Prevent penetration and leakages
Important for the urinary bladder
Desmosomes
Anchoring junctions
Made of interlocking filaments
Filaments penetrate from the plaque into the cytoplasm to stabilize the bond
Important for areas with lots of stretching
Skin heart and uterus
Gap junctions
Communicating junctions
Fluid filled tunnels between the cells
Connexons: tubular channel proteins link adjoining cells
Allows rapid exchange of nutrients and ion change signals
Microvilli
Finger like projections
Non-motile
Bush border of the cell
Increases surface area for better absorption and secretion
Cilia
Thousands of hairlike structures
Motile: in a wave like motion
Helps move mucus and debris out of things like the trachea
Simple squamous epithelia
Single layer of cells
Scale like with irregular outlines
Thin
Reduces friction, filtration and nutrient exchange
Air sacs of lungs, lining blood vessels and heart, pleura/peritoneal/pericardial lining
Simple cuboidal epithelia
Single layer, cube shaped cells
Lining, secretion, absorption
No protection from abrasion
ovary, kidney tubules, pancreas
Simple columnar epithelia non ciliated
No cilia but has microvilli
Absorption, secretion and protection with goblet cells
Gastrointestinal tract
Simple columnar ciliated epithelia
Moves fluids or particles along passage ways by ciliary action
Uterine tubes, paranasal sinuses, spinal cord canal
Stratified squamous epithelia
Skin
Cuboidal/columnar at the basal layer
As the cells die and move up they become keratinized and squamous
Protection
Stratified cuboidal epithelia
Protection
Ducts of sweat glands, mammary glands, salivary glands
Stratified columnar epithelia
Protection and secretion from goblet cells
Rare: parts of urethra, pharynx
Pseudostratified columnar epithelia
All cells are attached to the basal layer but other some reach the surface
The nuclei are found at different levels and give the appearance of being stratified (actually simple)
Can be plain or ciliated
Often contain goblet cells
Upper respiratory tract or glandular ducts
Protection, secretion, movement of mucus by ciliary action
Transitional epithelia
Good in areas with lots of stretching like the urinary bladder
Start off as stratified and cuboidal/columnar and as they stretch they become squamous and simple
Permits distension without leakage
Holocrine secretion
Gland fills with secretory material and discharges entire cell contents
Completely destroys the cell
Merocrine secretion
Gland has vesicles which pass secretory material through the cell membrane without any significant loss of cytoplasm
Apocrine secretion
Secretory material gets pushed to the apex of the cell and the apex explodes releasing the secretion
Only some cytoplasm is lost
Steps of inflammation
1: very short lived vasoconstriction
2: histamine and heparin are released from mast cells and causes vasodilation this causes redness and swelling and brings nutrients to the area
3: fluid enters the area and furthers swelling and irritates the nerve
4: a clot forms and a net of fibrin forms to trap bacteria and isolate the site, if it is on the skin it is called a scab which protects and covers the wound
5: macrophages and neutrophils enter the area and clear debris and bacteria and these quickly die to form pus
6: histamine and heparin levels drop and the swelling and redness settles down
First intention wound healing
Wound edges are close in apposition and results in minimal scarring
Second intention wound healing
Wound edges separated and granulation tissue forms over the gap and a moderate scar forms
Third intention wound healing
Large extensive wound gap with severe scarring and delayed healing
Osteoblasts
Form bone
Adds Minerals to ossify
Metabolically active
Osteocytes
Osteoblasts that have been trapped in lacunae of ossified matrix
Can convert to osteoblasts when needed (injury)
Less metabolically active than osteoblasts
Osteoclasts
Cells that eat away or remove bone
Important for remodelling and growth
Allows body to withdraw calcium from bone
Osteon or haversian system
Functional unit of compact bone
Nutrient foramina
Large channel through which arteries, veins, and nerves penetrate to feed the bone marrow
Endochondral bone formation
Bone grows into and replaces cartilage framework
Intramembranous bone formation
Bone develops from fibrous tissue membranes
Fibrous tissue membranes cover the brain of the fetus and as it matures these membranes are ossified
Calcitonin
Decreases blood calcium levels
Inhibits the release of calcium from bones
Spina Bifida
A cleft or space in the dorsal part of the vertebral column
Hemi vertebrae
Failure if the vertebral body to ossify resulting in an improperly formed or shaped vertebrae
Wobblers
Cervical intervertebral instability
Narrowing of the spinal canal and compresses the spinal cord
Common in dobermans, Great Danes and horses
Luxation
Dislocation
Intervertebral disc disease
Degeneration of the intervertebral discs
Fracture healing
Fracture hematoma forms
Osteoblasts invade area and start to form in a callus
Calcium salts are deposited to ossify the callus
Initial healing complete
Slow twitch fibers
Slower to contract
Sustained contractions for longer
Aerobic
More mitochondria and myoglobin
Fast twitch fibers
Fast contractions
Fatigue easily
Short bursts of contractions
Powered by ATP and not much oxygen
Smooth muscle
Involuntary Nonstriated Single nuclei Unbranched Nerve supply is not needed for visceral muscle but is needed for multi unit muscle
Cardiac muscle
Involuntary Striated Single nuclei Branched Nerve supple needed to contract
Skeletal muscle
Voluntary Striated Multinucleated Unbranched Nerve supply needed for contraction
Order of the layers of the heart from most outer layer to most inner layer
1: fibrous pericardium
2: parietal pericardium
3: pericardial space
4: visceral pericardium/epicardium
5: myocardium
6: endocardium
S1
Atrioventricular valves closing during ventricular contraction
“Lub”
S2
“Dub”
Closing of the semilunar valves at the end of systole
S3
Passive filling of the ventricles
S4
Atrial contraction
Tetralogy of fallout
Pulmonic stenosis
Interventricular septal defect
Malpositioning of the aorta
Ventricular hypertrophy
Murmurs
Abnormal heart sounds
Arrhythmias
Abnormal rhythms or rates
Left sided heart failure
Congestive heart failure
Back pressure increases at the end of Pulmonary capillaries and forced fluid out causing edema
Lung congestion
Right sided heart failure
Fluid backs up into the abdomen/venacaves Jugular veins engorged Ascites: fluid build up in abdomen Hydrothorax: fluid build up in chest Subcutaneous edema
Route for passing a stomach tube
Ventral nasal meatus
Surfactant
Chemical that reduces the “stickiness” of the alveolar walls and assists in expansion during breathing and prevents lung collapse
Pneumothorax
Air leaks into the space between the lung and thoracic wall
Keratinocyte
Gives resiliency and strength Waterproofs the skin Majority of cells Produced at the basal layer As cells move up from basal layer, it dies and become keratinized Sloughed off at the surface (shed)
Epidermis
Outermost layer of skin
No blood vessels
Melanocyte
Less common
Found on basal layer
Produces melanin pigment
Protects against UV light
Langerhan cells
Type of macrophage
Phagocytizes micro-invaders
Merkel cells
In the basal layer
Associated with sensory nerve endings
5 layers of hairless epidermis
1: stratum corneum (cornified)
2: stratum lucidum (clear)
3: stratum granulosum (granular layer)
4: stratum spinosum (spiny layer)
5: stratum germinativum (basal layer)
3 layers of hairy epidermis
1: stratum corneum
2: stratum spinosum
3: stratum basale
Has folds of skins which hair grows out of
Epidermal papillae: where tactile hairs grow from
Dermis
Tough layer
Highly fibrous: dense irregular connective tissue (collagen runs is different directions) (very strong)
Has: hair follicles, nerve endings, glands, smooth muscle, blood vessels, lymphatic channels
2 layers of the dermis
Papillary layer: thin superficial layer
Nerve endings
Reticular layer: majority of the dermis
Hypodermis
Subcutaneous layer
Primarily adipose tissue
Thick layer below the dermis
Contains pacinian corpuscles: special touch receptor for heavy pressure
Allows skin to move freely over underlying structures
Two basic types of of melanin
Black and orange
Shading and darkness depends on
How much melanin is present
Albinos produce
No melanin
Paw pads
Thick layer of fat and connective tissue covered by thick epithelium
Paw pads functions
Shock absorbers
Insulation
Protection
Thickest and toughest skin on the body (has all 5 layers)
Paw pads
Do paw pads have exocrine glands
Yes, this is where most animals sweat from
Except for horses