Final Exam :) Flashcards

1
Q

what does blood plasma contain

A

it is mostly water plasma proteins, and dissolved solutes

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2
Q

what is it called if a patient has a blood pH less than 7.35

A

acidosis

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3
Q

what is it called if a patient has a blood ph greater than 7.45

A

alkalosis

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4
Q

what is the normal ph of blood

A

it is more alkaline in the range of 7.35-7.45

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5
Q

a single hemoglobin molecule can carry up to how many oxygen molecules

A

4

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6
Q

what are the formed elements of blood

A

red blood cells-99.9
white blood cells
platelets

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7
Q

hemopoiesis

A

the process of producing formed elements by myeloid and lymphoid stem cells

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8
Q

what is the technical term of formed elements

A

erythrocytes
leukocytes
thrombocytes

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9
Q

what is the major function of erythrocytes

A

transporting both respiratory gasses (oxygen and carbon dioxide)

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10
Q

what are the main symptoms of liver failure, blocked bile duct, or hepatitis

A

develop jaundice due to bilirubin buildup

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11
Q

what blood test gives the percentage of whole blood contributed by formed elements (mostly rbc) the volume

A

hematocrit

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12
Q

what is the test to see more specific count on blood (wbc). complete blood count

A

differential

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13
Q

what are the white blood cells

A

granulocytes:
neutrophil
eosinophil
basophil
agranulocytes:
lymphocyte
monocyte

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14
Q

what are the percentages of wbc

A

neutrophil-60-70%
lymphocytes- 25-35%
monocytes- 3-8%
eosinophil- 2-4%
basophil- <.5%

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15
Q

technical terms of low and high count rbc

A

low-anemia
high- erythrocytosis/polycythemia (inflammation)

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16
Q

technical terms of low and high platelet count

A

low- thrombocytopenia
high-thrombocytosis (at risk for heat attacks and strokes)

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17
Q

technical terms of low medium and high count of wbc

A

low- leukopenia (severe infection)
moderate increase- leukocytosis (regular infection)
very high- leukemia (cancer in bone marrow)

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18
Q

erythropoietin hormone (5)

A

its released from the kidneys
released when there’s a decrease blood flow or oxygen delivery to kidneys
it’s released during anemia
stimulates red blood cell production

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19
Q

most common wbc in a healthy individual

A

neutrophil

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20
Q

thrombocytopenia shows symptoms

A

patient may experience bleeding and have a count less than 150.000 cells/microliter of blood

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21
Q

coagulation ultimately results in the formation of what insoluble protein

A

fibrin

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22
Q

major difference between plasma and interstitial fluid

A

plasma has plasma proteins

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23
Q

the function of hemoglobin

A

bind and transport oxygen and carbon dioxide in the blood

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24
Q

red blood cell removal characteristics

A

worn out rbc are removed by macrophages
subunits are broken down and their amino acids are recycled
heme is broken down into biliverdin then bilirubin which is waste
hemoglobinuria occurs if rbc are not removed properly

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25
what’s the difference between red blood cells and hemoglobin
hemoglobin is a protein within red blood cells. they are just a component.
26
how is iron removed from red blood cells
transferrin to get recycled
27
the production of red blood cells requires
amino acids vitamin b6 iron b12 folic acid
28
where are plasma proteins made
made in the liver
29
what is red blood cell production called and where does it happen
erythropoiesis in the bone marrow
30
what stimulates erythropoiesis
erythropoietin and multi-csf
31
hemolytic disease of new born can occur in what blood type combo
Eh neg mom, Rh positive baby
32
what cells originate at lymphoid stem cells
lymphocytes
33
what white blood cells increase inflammation
neutrophils and basophils
34
neutrophils
cause inflammation and the first to attack bacteria engulf and digest pathogens
35
what enzyme converts fibrinogen to fibrin
thrombin
36
what coagulation pathway leads to activation of factor x
intrinsic pathway and extrinsic pathway
37
factor 3 is important to what coagulation pathway
extrinsic pathway
38
the platelet phase of hemostasis is the formation of what
platelet plug
39
multi csf
stimulates production of all blood cells except lymphocytes
40
the structure of rbc
contain hemoglobin, small disks, biconcave, flexible membrane, no nucleus or organelles, high surface to volume ratio, form stacks called rouleaux
41
what do subunits get recycled as
amino acids and released into blood
42
stem cells of red blood cells
hemocytoblast>myeloid stem cells>erythrocytes
43
myeloid stem cells give us
everything but lymphocytes
44
lymphoid stem cells give us
ONLY lymphocytes
45
associations with leukopenia
hiv, chemo, or radiation
46
general function of wbc
defend against pathogens, remove wastes, remove abnormal cells like parasites
47
characteristics of wbc
migrate out of blood, amoeboid movement, use positive chemotaxis, can be phagocytes except for basophils
48
structure of wbc
no hemoglobin, have nuclei and organelles, bigger than rbc
49
colony stimulating factors
m-csf: monocytes g-csf: N,E, B gm-csf: M,N,E,B multi-csf: rbc, platelets, M,N,E,B
50
what is the universal donor and universal receiver
donor- O- receiver- AB+
51
hemoglobin structure
4 protein sub units- bind to co2 4 heme molecules 4 iron ions- bind to o2
52
general function of wbc
neutrophils- phagocytes increase inflammation lymphocytes- specific acquired immunity: b cells, nk cells, t cells monocytes- become macrophages, powerful phagocytes eosinophils- decrease inflammation, increase in allergic reactions and parasitic infections basophils- release histamine increases inflammation. release heparin prevents blood clots
53
in the vascular phase of hemostasis what hormone is present
endothelins
54
in the vascular phase of hemostasis what happens
cause constriction of the vessels. plasma gets sticky
55
in the coagulation phase of hemostasis what happens
a chemical reaction leads to the production of a fibrin clot
56
thrombopoiesis platelet production occurs
hemocytoblasts> myeloid stem cells> megakaryocytes> platelets
57
platelet production is stimulated by
multi csf and thrombopoiesin
58
the path of blood thru heart
right atrium- deoxygenated blood goes in to go to ventricle right ventricle-pumps deoxygenated blood to lungs left atrium- receives oxygenated blood to go to ventricle left ventricle- pumps oxygenated blood to body
59
right atrioventricular valves
tricuspid valve prevents blood going back into the atrium from ventricle. has 3 cusps.
60
left atrioventricular valve
bicuspid valve prevents blood from going back into atrium from ventricle. has 3 cusps
61
right semi lunar valves
pulmonary semi lunar valve at the base of the vessels leading from right ventricle to the pulmonary trunk prevents back flow to the right ventricle
62
left semi lunar valve
aortic semi lunar valve at the base of the vessel leading from the left ventricle to the aorta prevents back flow from the left ventricle
63
desmosomes of myocardium
secure adjacent cell membranes together
64
gap junctions of myocardium
allow ions to pass cell to cell to transfer action potential
65
what is S1 of the heart
the atrioventricular valve closing during ventricular systole (contraction)
66
what is S2 of the heart
when the semilunar valves close during ventricular diastole (relaxation)
67
heart murmur
gurgling sound if the valves don’t close correctly
68
gap junction
linked together with these to allow ions flow directly form one cell to the other to transfer action potential
69
what is the conduction system of heart
electrical system
70
what stimulates cardiac muscles to contract
influx of sodium ions
71
sa
72
sa node
spontaneously stimulated, starts every stimulus. basic pace maker, it gets depolarized
73
path of stimulus
sa node> thru atria > av node> av bundle (septum)> bundle branches>purkinje fibers> myocardium of ventricles
74
where is action potential delayed in the heart and why
av node so it gives time for atria to contract
75
purkinje fibers
passes the stimulus thru the myocardium of the ventricles at the bottom of the heart
76
what measures the electrical events in the heart
electrocardiogram
77
on ekg the stimulation of the atria, contraction, depolarization
p wave
78
on ekg the stimulation of the ventricles( the up and down), contraction, depolarization
qrs complex
79
on ekg the repolarization of the ventricles, relaxation
t wave
80
sympathetic neurons in cardiac center of brain release this to do this
epinephrine to increase heart rate
81
parasympathetic neurons in cardiac center of brain release this to do what to heart rate
AcH to decrease heart rate
82
the maximum volume of ventricles when it is full, at relaxation
end diastolic volume
83
the minimum volume in ventricles left over after the contraction
end systolic volume
84
edv - esv =? 100ml= edv 30ml= esv
stroke volume 70mp
85
the amount of blood pumped by the left ventricle in 1 minute. give an equation
cardiac output hr * sv = co
86
when sodium channels open and rapidly enter cell making it less negative
rapid depolarization phase
87
when sodium in pumped of the gel and calcium is let into the cell as voltage stays the same
plateau phase
88
the phase where potassium flows out of the cell making it more negative
repolarization
89
regular capillaries
continuous capillaries
90
pores in the endothelial lining of capillaries
fenestrated capillaries
91
very permeable capillaries that occur in bone marrow etc. gaps between endothelial cells
sinusoids
92
special continuous capillaries have this
tight junctions between endothelial cells, this occurs in blood brain barrier
93
capillaries only have what
tunica intima
94
primary pressure that pushes out of the blood, also called filtration
capillary hydrostatic pressure
95
primary pressure that pulls back into the bloodstream in capillaries
blood osmotic pressure, reabsorption
96
what is the main cause of blood osmotic pressure
plasma proteins
97
what is the main association with capillary hydrostatic pressure
blood pressure
98
accumulation of interstitial fluid that causes swelling, bc of starvation, tissue damage, increased blood pressure, blood clots, heart failure, liver failure
edema
99
removal of lymph nodes
lymphedema