Final Exam! Flashcards
what is the pathway of a RBC through the kidney
renal artery
segmental artery
interlobar artery
arcuate artery
cortical radiate artery
afferent arteriole
glomerulus
efferent arteriole
peritubular capillaries (vasa recta, juxtamedullary nephron)
cortical rediate vein
arcuate vein
interlobar vein
renal vein
What are the functions of the urinary system
excretion, regulation of blood volume and blood pressure, regulation of plasma ions, regulation of extracellular fluid pH, regulation of nutrients and vitamin D synthesis, regulation of erythrocyte production (EPO, eyrthroprotein)
What are two major parts of the nephron
renal corpuscle and renal tubule
what are the two parts of the renal corpuscle
bowman’s capsule, glomerulus
what are the three parts of the renal tubule
proximal convoluted tubule, loop of Henle, distal convoluted tubule
what are the three parts of the filtration membrane
podocyte cell processes, basement membrane, fenestrated capillary
what is the name of the vessel that brings blood to the glomerulus
afferent arteriole
blood is filtered across the _________
filtration membrane
what is the name of the vessel that blood exits the glomerulus through
efferent arteriole
what are the steps to urine formation
filtration
reabsorption
secretion
where does filtration in urine formation take place
the renal corpuscle
where does reabsorption in urine formation take place
along the PCT
where does secretion in urine formation take place
along the PCT
what is the path of a water molecule through the kidney
renal corpuscle
PCT
Descending limb of nephron loops
loop of henle
ascending limb of nephron limn
DCT
collecting duct
papillary duct
renal papilla
minor calyx
major calyx
renal pelvis
ureter
urethral orifice
urinary bladder
internal urethral orifice
urethra
internal urethral sphincter
external urethral sphincter
external urethral orifice
What is the glomerular capillary pressure
50 mm Hg
which force promotes filtration
glomerular capillary pressure
what are the opposing forces of glomerular capillary pressure
colloid osmotic pressure and capsular pressure
what is colloid osmotic pressure
30 mm Hg
what is capsular pressure
10 mm Hg
What is the net filtration pressure
10 mm Hg
How does filtration work?
the direction of the force moves material out of the blood and into the Bowman capsule
List examples of filterable molecules
water
ions (sodium, potassium, chloride)
nutrients (glucose, amino acids)
wastes (urea, uric acid, creatinine)
list examples of what is too large to filter
blood cells
plasma proteins
How is the PCT modified for reabsorption
the brush border
how does Na+ get transported
active transport (Na/K pump)
How does Cl- get transported
passive transport, follows Na+
how does glucose get transported
passive transport, facilitated diffusion
active transport, co-transport w/ Na+
how does water get transported
osmosis
What molecules have a fixed number of carrier proteins for reabsorption
glucose and amino acids
What happens when the number of glucose molecules exceeds the number of carrier proteins
glucose appears in the urine
what is the term for increased urine production
diuresis
what is osmotic diuresis
increased water loss from excess solutes in urine
what causes osmotic diuresis
diabetes mellitus
What ion drives reabsorption of solutes and water
sodium
hydrogen ions are secreted when sodium is reabsorbed through
countertransport
65% of the filtrate is reabsorbed in the
PCT
100% of what molecules are reabsorbed
glucose, amino acids
What percent of sodium ions are reabsorbed
80%
the descending limb is permeable to
water
the ascending limb is permeable to
NaCl
what is the name for medications that act on the loop of henle and inhibit Na+, Cl-, and K+ reabsorption
loop diuretics
what hormone causes K+ secretion and Na+ reabsorption
aldosterone
Why are hydrogen ions secreted
to balance pH
what is the use of drugs like penicillin
to prevent toxicity
DCT is primarily responsible for
secretions
What is the stimulus for the renin-angiotensin-aldosterone mechanism
low BP or low glomerular filtration rate
What is normal glomerular filtration rate
125 mL/min
What is the result of the renin-angiotensin-aldosterone mechanism
increased BP
increased Blood Volume
What type of feedback mechanism is the renin-angiotensin-aldosterone mechanism
negative feedback
What does aldosterone target
the DCT
What usually causes a UTI
E. coli
the inability to voluntarily control urination
incontinence
urination
micturition
bladder infection
cystitis
drugs to promote urination
diuretics
painful of difficult urination
dysuria
what is hypernatremia
elevated blood sodium
what is hyponatremia
deficiency of blood sodium
what is hyperkalemia
elevated blood potassium
what is hypokalemia
deficiency of blood potassium
what is hypercalcemia
elevated blood calcium
what is hypocalcemia
deficiency of blood calcium
What senses increased blood solute concentration or large decrease is BP
osmoreceptors
What does ADH target
DCT and collecting ducts
what is an antagonist of aldosterone
ANH
What does ANH inhibit and promote
inhibits Na+ resorption
promotes water loss
how does caffeine affect urine production
inhibits Na+ and other ion reabsorption
increases urine volume/output
how does alcohol affect urine production
inhibits release of ADH
What is ADH effect on urine output
decrease
what is ANH effect on urine output
increase
What controls micturition
the parasympathetic nervous system
What is the amount of urine that signals the urge to urinate
200 mL
What are the steps to micturition reflex
stretch receptors signal parasympathetic neurons
parasympathetic neurons in sacral region cause contractions of detrusor muscle
external urethral sphincter relaxes then internal urethral sphincter relaxes
when urine exceeds 500mL the internal and external sphincter are forced open
What is the composition of Urine
95% water
urea
creatinine
uric acid
where does urea come from
amino acid catabolism
where does creatinine come from
muscle metabolism
where does uric acid come from
nucleic acid catabolism
what is glycosuria
presence of glucose
what is ketonuria
presence of ketones
what is albuminuria/proteinuria
present of protein or albumin
what is bilirubinuria
presence of bile pigments
what is hematuria
presence of RBCs
what is pyruria
presence of WBCs
what delivers fluids and solutes to the interstitium
plasma
high osmotic pressure attracts
water
high osmolarity =
high NaCl
what are the major electrolytes
sodium, potassium, calcium
what regulates Na concentrations
aldosterone
what are the major functions of sodium
fluid and pH balance
what regulates K concentrations
aldosterone
what are the major functions of potassium
fluid balance
what regulate Ca concentrations
PTH
what can the 3 electrolytes all function in
muscle contraction, nerve impulse conduction, heart action
what is the normal blood acidity range
7.35-7.45
when PCO2 rises, pH _____
falls
when PCO2 falls, pH
rises
When blood pH is less than 7.35, there is a low
Blood HCO3-
when blood pH is greater than 7.35, there is a high
blood HCO3-
term for low blood HCO3-
metabolic acidosis
term for high blood HCO3-
metabolic alkalosis
how long does renal compensation take to kick in
3-5 days
what happens during renal compensation
H+ is secreted and bicarbonate is reabsorbed
What is in the ICF
cytoplasm
What is in the ECF
interstitial fluid, plasma, bone and dense connective tissue
What are the stages of meiosis and meiosis too
early prophase 1
middle prophase 1
metaphase 1
anaphase 1
telophase 1
prophase 2
metaphase 2
anaphase 2
telophase 2
what is the end result of meiosis 1 regarding chromosomes
separate homologous pairs
what is the end result of meiosis 2 regarding chormosomes
separation of sister chromatids
what is cryptorchidism
a condition where the testes don’t descend properly, requires surgically correction
how does cryptorchidism effect fertility
men with this condition are infertile due to sperm needing a lower body temp in order to be viable
What is spermatogenesis
sperm formation
what is the purpose of interstitial cells
produce testosterone
what is the purpose of nurse cells
nourish developing spermatocytes
what is the function of the rete testis
maze like tubules where seminiferous tubules combine as they leave the testis
what do sperm use for ATP productions
fructose
what is capacitation
sperm become active, motile and fully functional; requires contact with seminal vesicle secretions, female reproductive tract secretions
What is the process of sperm formation
spermatogonia
primary spermatocytes
secondary spermatocyte
spermatid
spermatozoa
what is the pathway of sperm through the male reproductive system
testis
seminiferous tubules
rete testis
epididymis
vas deferens
ejaculatory duct
prostatic urethra
membranous urethra
penile urethra
external urethral orifice
What are the functions of seminal vesicles
alkaline secretions, provide fructose to flagellum, secretion of prostaglandins
what are the functions of the prostate
acidic secretions, seminalplasmin
what are the functions of the bulbourethral glands
thick, alkaline mucus, neutralize acids, lubricate the glans penis
Where does GnRH come from
hypothalamus
when does GnRH begin being secreted
puberty
where does FSH and LH come from
anterior pituitary
what is the function of FSH and LH
target the gonads
What stimulates testosterone from interstitial cells
LH
what stimulates inhibin from sustentacular cells
FSH
What type of feedback mechanism effect does Inhibin have on the anterior pituitary in order to reduce FSH secretion
negative feedback
What are the functions of testosterone
Maturation of sperm
maintain accessory organs
secondary sex characteristics
what is the pathway of sperm through the female reproductive tract
vagina
external os
cervical canal
internal os
uterine cavity
uterine tube
where does fertilization occur
the upper third of the uterine tube
What are the stages of follicular development
primordial follicle
primary follicle
secondary follicle
mature follicle
corpus luteum
corpus albicans
What are the stages of the ovarian cycle
follicular phase
ovulation
luteal phase
in what stage of the ovarian cycle is estrogen most present
follicular phase
in what stage of the ovarian cycle is progesterone most present
luteal phase
What are the stages of the uterine cycle
menses
proliferative phase
secretory phase
what are the function of estrogen
bone and muscle growth
female secondary characteristics
sex drive
accessory reproductive organs
build up of endometrial cells
What are the characteristics of menopause
ovaries unresponsive to FSH and LH, decreased estrogen levels
what are the characteristics of andropause
male climacteric, decline in testosterone production, more gradual that menopause