Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

PHARM > FINAL! > Flashcards

FINAL! Flashcards

1
Q

ADRENERGIC AGONISTS

MED
USED FOR
RECEPTORS (4 KINDS)

A

EPINEPHRINE

USED IN ANAPHYLACTIC SHOCK TO INCREASE BP, HR, AIR IN LUNGS!!!!!!

PUPIL DILATION, BRONCHODILATION

ALPHA 1 (NASAL CONGESTION, HYPO, DILATE PUPILS
ALPHA 2 (HYPER)
BETA 1 (CARDIAC ARREST, HF, SHOCK)
BETA 2 (ASTHMA, PRE LABOR CTX)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

ADRENERGIC ANTAGONISTS
BETA 1 ADRENERGIC BLOCKER

MED
TREAT
DECREASE
S/E

A

ATENOLOL

TREAT HTN, ANGINA, PROPHYLAXIS, MI

DECREASE HR AND BP, CTX, CARDIAC OUTPUT

S/E = BRADYCARDIA, HYPO, HA, DIZZY, BRONCHOSPASM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

CHOLINERGIC AGONIST

MED
INCREASE
S/E

A

BETHANECHOL CHLORIDE

INCREASE URINE!!!!!

S/E: HYPO, TACHY, SALIVATE, INCREASE ACID, D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

ANTICHOLINERGIC

MED
DECREASE
INCREASE
BLOCKS
S/E

A

ATROPINE

DECREASE SALIVARY AND RESPIRATORY!!!
INCREASE HR!!!, DILATE PUPILS

BLOCKS ACETYLCHOLINE

S/E: DRY MOUTH, BLUR, TACHY, C, URINARY RETENTION

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

ANTISEIZURE DRUGS ACT IN WHAT 3 WAYS?

A

-INCREASE GABA (INHIBIT NEUROTRANSMITTERS)

-SUPPRESS SODIUM INFLUX

-SUPPRESS CALCIUM INFLUX

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

ANTISEIZURE: PHENYTOIN (DILANTIN)

S/E

A

S/E: DEPRESS, SUICIDE, STEVEN, VFIB, THROMBOCYTOPENIA, LEUKOPENIA, N/V, GINGIVAL HYPERPLASIA!!!, NYSTAGMUS, C, DROWSY

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

ANTISEIZURE: VALPROIC ACID

A/E

A

A/E = HEPATOTOXICITY (LIVER)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

ALZHEIMERS (ACETYLCHOLINESTERASE INHIBITOR)

MED
INCREASE
DECREASE

A

RIVASTIGMINE (EXELON)

INCREASE ACH AND COGNITIVE
DECREASE DISEASE PROCESS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

PARKINSONS (CHOLINERGIC ANTAGONISTS)

MED
BLOCK
S/E
INTERVENTIONS

A

TRIHEXYPHENIDYL (ARTANE)

BLOCK ACH

S/E: N/V, BLUR, CONFUSE, DRY, C, DIZZY, RESTLESSNESS, ANXIETY, TACHY, URINE RETENTION

MONITOR UO, INVOLUNTARY MOVEMENTS, NO ASPIRIN, AVOID GLAUCOMA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

PARKINSONS (DOPAMINERGICS)

MED
WHAT IS CONVERTED
INTERVENTIONS

A

CARBIDOPA-LEVODOPA (SINEMET)

LEVODOPA CONVERTED TO DOPAMINE

DONT CRUSH EXTEND RELEASE, LOW PROTEIN FOOD, NO VB6 (DECREASE LEVODOPA), HARMLESS BROWN DISCOLORATION URINE AND SWEAT , “ON - OFF”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

ANTIPSYCHOTICS

NEUROLEPTIC MALIGNANT SYNDROME
S/S
TX

A

S/S = BAD MENTAL, SEIZURE, MUSCLE RIGID, FEVER, SWEAT, TACHY, BP FLUCTUATION, RENAL FAIL, RESP FAIL, COMA

TX= STOP ANTIPSYCHOTICS, WATER, HYPOTHERMIC BLANKETS, ANTIPYRETICS, BENZOS AND MUSCLE RELAC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

ANTIPSYCHOTICS
CONVENTIONAL (TYPICAL)

A

HALOPERIDOL (HALDOL)

BLOCKS POSITIVE SYMPTOMS, ALTERS DOPAMINE

TX= ACUTE PSYCHOSES, ADHD, SCHIZO, TOURETTE

NON-PHENOTHIAZINES

CHEMICAL STRUCTURE DIFFFERENT

INCREASE SEDATION WITH ALCOHOL, INCREASE TOXICITY WITH ANTICHOLINERGICS, DEPRESSANTS

DECREASE EFFECTS WITH PHENOBARBITAL, CARBAMAZEPINE, COFFEE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

ANTIPSYCHOTICS
ATYPICAL

S/E

A

ARIPIPRAZOLE (ABILIFY)

TREAT + AND -
WEIGHT GAIN, DM, DROWSY, DYSLIPIDEMIA

S/E = FEWER THAN PHENO AND NONPHENO, WEIGHT LOSS AND GAIN!!!!

AGONIST @ DOPAMINE AND SEROTONIN RECEPTORS
NO RISK FOR BIRTH DEFECTS
METABOLIC SYNDROME

NO EPS
FIRST LINE THERAPY

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

ANXIOLYTICS
BENZODIAZEPINES

LORAZEPAM (ATIVAN)
S/E
TEACHING

A

S/E: SEDATION, DIZZY, HA, DRY MOUTH, DECREASE VISION, CONSTIPATION, DECREASE SEX, EUPHORIA, DROWSY, RESTLESS
A/E: LEUKOPENIA

CONTRAINDICATION W PREGNANCY

INCREASE GABA

ANXIETY, STATUS EPILEPTICUS, INSOMNIA

BC, SMOKING, CAFFEINE, ANTACIDS DECREASE EFFECTS

KAVA = SEDATIVE

SMOKING INCREASE CLEARANCE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

ANTIDEPRESSANTS
TRICYCLICS

BLOCKS

A

BLOCK REUPTAKE OF NOREPIN AND SEROTONIN
BLOCK HISTAMINE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

ANTIDEPRESSANTS
SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIs)

FLUOXETINE (PROZAC)

BLOCKS
TREATS

A

BLOCK REUPTAKE OF SEROTONIN
MAJOR DEPRESSIVE, ANXIETY, OCD, PANIC, PHOBIAS, PTSD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

ANTIDEPRESSANTS
SEROTONIN NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIs)

VENLAFAXINE (EFFEXOR)

S/E
A/E

A

INHIBIT REUPTAKE OF SEROTONIN AND NORE, NERVE FIBERS

MAJOR DEPRESSION, GENERAL ANXIETY AND SOCIAL

S/E: DROWSY, DIZZY, INSOMNIA, HA, EUPHORIA, AMNESIA, BLURRED VISION, PHOTOSENSITIVITY, DECREASE EJACULATION

A/E: O HYPOTENSION, HTN, ANGIOEDEMA, BLOOD DYSCRASIAS, SUICIDE, STEVEN JOHNSON

+ ST JOHNS WORT = RISK OF SEROTONIN SYNDROME

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

ANTIDEPRESSANTS

SEROTONIN SYNDROME

A

HAPPENS HOURS OF TAKING A NEW MED
INCREASING MED PATIENT IS ON

FEVER, SEIZURES, RESTLESSNESS, HIGH BP, LOSS OF MUSCLE, RIGIDITY, DIAPHORETIC, WEIRD HR, TACHYCARDIC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

ANTIDEPRESSANTS

MONOAMINE OXIDASE INHIBITORS (MAO-I)

A

DECREASE EFFECT OF MONOAMINE OXIDASE (INACTIVATES NORE, DOPA, EPINE, SERO)

DRUG INTERACTION: VASOCONSTRICTORS AND COLD MEDS (PHENYLEPHRINE AND PSEUDOEPHEDRINE) = HTN CRISIS

FOOD INTERACTION: TYRAMINE = HTN CRISIS

S/E: O HYPOTENSION, INSOMNIA, ANTICHOLINERGIC AFFECTS

INCREASE BP AND HR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

ANTIDEPRESSANTS

PATIENT TEACHING!!!

DO NOT USE WHAT AFTER STOPPING WHAT

A

8 WEEKS FOR IMPROVE

DO NOT USE SSRI, TCA, AND OTHER ANTIDEPRESSANTS FOR 14 DAYS AFTER STOPPING MAOI = SEROTONIN SYNDROME

TCA NO SMOKING (DECREASE EFFECT)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

MOOD STABILIZERS

MED
S/E
TEACH

A

LITHIUM CARBONATE

S/E: HA, LETHARGY,N/V, MEMORY LOSS, HAND TREMORS, PERIPHERAL EDEMA, DEHYDRATION, POLYURIA, METALLIC TASTE!!!!!

A/E: DYSRHYTHMIAS, SEIZURE, CARDIAC ARREST, DIABETES INSIPIDUS

DECREASE SODIUM = INCREASE LITHIUM!!!!!!!

PATIENT TEACHING!!!
AVOID OPERATING MACHINES
1 TO 2 WEEKS
AVOID CAFFEINE, CRASH DIET, NSAID, DIURETICS
NO BABY
NO ACTIVITIES = SODIUM LOSS!!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

CARDIAC GLYCOSIDES

MED
INTERVENTIONS

A

DIGOXIN

INTERVENTIONS:
APICAL PULSE RATE BEFORE GIVING
PERIPHERAL AND PULMONARY EDEMA
K (HYPOKALEMIA)
HOLD IF HR <60!!!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

ANTIANGINALS

MED
TEACH
INTERVE

A

NITROGLYCERIN

TEACHING:
HA COMMON (DECREASE)
ACETAMINOPHEN FOR PAIN
DO NOT CHEW OR SWALLOW SL TABLETS. UNDER TONGUE AND DISSOLVE OR BUCCAL POUCH

INTERVENTIONS
MONITOR ECG
AVOID ALCOHOL, CAFFEINE, TOBACCO

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

DIURETICS

THIAZIDE AND THIAZIDE LIKE (HYDROCHLOROTHIAZIDE HCTZ)

ACTION
TREAT
LOSS
CAUSE
TAKE IN

A

ACTION: DISTAL CONVOLUTED RENAL TUBULE TO PROMOTE SODIUM, CHLORIDE, WATER EXCRETION

TREAT: HTN, PERIPHERAL EDEMA, HF, CAN USE WITH ACE

LOSS OF SODIUM, K!!!, MAG,
CAUSE HYPERCALCEMIA

TAKE IN AM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
DIURETICS LOOP - FUROSEMIDE (LASIX) MORE WHAT IN NEPHRON USED GIVE SLOW WHY DIGOXIN CAUSES
MOST POWERFUL MORE SODIUM IN NEPHRON (WATER IN NEPHRON INSTEAD BLOOD) USED FOR HF, ASCITES, PULMONARY EDEMA, HTN, HYPERCALCEMIA INCREASE RENAL BLOOD FLOW GIVE SLOW (HEARING LOSS) HYPOKALEMIA!!! (DIGOXIN K LEVELS)
26
DIURETICS POTASSIUM SPARING (SPIRONOLACTONE-ALDACTONE) CONSERVES USED FOR A/E GIVE IN AVOID
DOES NOT AFFECT K LEVELS RID OF NA AND WATER USED FOR EDEMA, HTN, HF, HYPOKALEMIA A/E HYPERKALEMIA GIVE IN AM AVOID HIGH K FOODS, SALT SUBSTITUTES
27
DIURETICS OSMOTIC (MANNITOL - OSMITROL) INCREASE DECREASE (2)
INCREASE OSMOTIC PRESSURE REDUCE PLASMA VOLUME USED DECREASE ICP AND INTRAOCULAR (GLAUCOMA) CI: HF AND RENAL FAIL
28
ANTIHTN BETA 1 ADRENERGIC BLOCKERS MED DECREASE TREAT BAD FOR WHO
METOPROLOL SELECTIVE: BLOCK BETA 1 (HEART) DECREASE CARDIAC OUTPUT (SNS), HR, CTX, BP TREAT HTN, STABLE ANGINA, DYSRHYTHMIAS, MIGRAINES, GLAUCOMA, ANXIETY HF (PULMONARY EDEMA, WEIGHT GAIN) BAD FOR PREGO (C)
29
ANTIHTN CENTRALLY ACTING ALPHA 2 AGONISTS MED DECREASE USED FOR WHAT KIND OF RETENTION
CLONIDINE - CATAPRES DECREASE SNS, CO, EPI, NOREPI, RENIN RELEASE USED FOR DIFFICULT HTN WATER AND SODIUM RETENTION
30
ANTIHTN ACE INHIBITORS MED RESPONSE USED FOR S/E WHO MAY NOT RESPOND
ENALOPRIL (VASOTEC) ALONE OR W DIURETICS VASODILATION, LOW BP, DECREASED HEART WORK USED HF, POST MI S/E: DRY COUGH!!!, TACHY, HYPERKALEMIA, ANGIOEDEMA!!! (LIPS SWELL), RENAL FAIL BLACKS MAY NOT RESPOND NO PREGO NO K DIURETICS NO SALT SUBS WITH K
31
ANTI HTN ANGIOTENSION 2 RECEPTOR BLOCKERS (ARBS) MED NO WHAT RESPONSE EXCRETE USED
VALSARTAN (DIOVAN) SAME AS ACE (FEWER SE) NO COUGH!! VASODILATION DECREASED SVR AND BP EXCRETE SODIUM AND WATER USED FOR DIABETIC NEPHROPATHY (TYPE 2), HF
32
ANTI HTN CALCIUM CHANNEL BLOCKERS (CCBS) MEDS (2) MORE/LESS BLOCK WHAT CAUSES WHAT
DIHYDROPYRIDINES (NIFEDIPINE) MORE VASODILATION LESS HEART FUNCTION NON DIHYDROPYRIDINES (DILTIAZEM) LESS VASODILATION MORE HEART WORSE HF BLOCK CA = WEAK CTX REFLEX TACHY (BP DROPS = INCREASE HR) C (FIBER), ORAL CLEAN (GINGIVAL HYPERPLASIA)
33
ANTICOAGULANTS HEPARIN PREVENT WHAT MONITORS ANTIDOTE BEFORE STOPPING GIVE WHAT
PREVENT AND TREAT BLOOD CLOTS SQ OR IV APTT MONITORS HEP!!!! (ACTIVATED PARTIAL THROMBOPLASTIN TIME) S/E (BLEED, HIT, OSTEOPOROSIS) PROTAMINE SULFATE IV (ANTIDOTE)!!! BEFORE STOPPING, GIVE WARFARIN (ORAL) SAFE FOR PREGO BUT BLEEDING DURING LAST AND DELIVERY
34
ANTICOAGULANTS LOW MOLECULAR WEIGHT HEPARINS LAB MED ANTIDOTE
MORE STABLE APTT NOT REQUIRED-CAN GIVE AT HOME!! ENOXAPARIN (LOVENOX)!! SQ 1-2X DAILY ABD NO ASPIRIN OR IBU PROTAMINE SULFATE ANTIDOTE!! CI: STROKE, PEPTIC ULCER, BLOOD ANOMALIES
35
ANTICOAGULANTS ORAL ANTICOAGULANTS MED LABS ANTIDOTE
WARFARIN (COUMADIN) PROLONG CLOTTING MONITORED BY PROTHROMBIN TIME PT!!! DOSAGE - INR LAB!!!! NORMAL <1.1 ON WARFARIN (2-3) >3 BLEEDING VITAMIN K ANTIDOTE (PHYTONADIONE-AQUAMEPHYTON)!!! PREVENT THROMBOEMBOLIC NO ASPIRIN
36
ANTIPLATELETS ASPIRIN PREVENT S/E
INHIBIT CYCLOOXYGENASE PREVENT AND TREAT MI, THROMBOEMBOLISM, MAINTAIN GRAFTS, TIA, STROKES S/E (BLEED, GI) INTERA (NSAID, ANTICOAGULANTS)
37
ANTIPLATELETS CLOPIDOGREL (PLAVIX) PREVENT S/E A/E
PREVENT SECOND EVENT OF MI OR STROKE S/E (EPISTAXIS, HA, HEMATOMA, GI, PURPURA, RASH, PRURITIS) A/E (BLEED, PEPTIC ULCER, INTRACRANIAL BLEED)
38
ANTIPLATELET INTERVENTION TEACHING
INTERVENTION ALLERGY TO ASPIRIN MONITOR PLATELET OBSERVE BLEED TEACH TAKE WITH MEALS AVOID PRODUCT W ASPIRIN NSAIDS ALCOHOL = BLEED
39
THROMBOLYTICS MED CI
ALTEPLASE T-PA (ACTIVASE) DISSOLVE CLOTS FOR MI, THROMBOLIC STROKE, PULMONARY EMBOLISM, DVT, NONCORONARY ARTERIAL OCCULSION S/E BLEED CI: INTERNAL BLEED, BLEED DISORDERS, ANEURYSM, SURGERY, TRAUMA, !!!!!! PREGNANT: MISCARRIAGE 5 MONTHS, CI IF BIRTH PAST 24 HRS NO ASPIRIN NSAID NO INJECTIONS ARM LEG PAIN
40
ANTIBACTERIALS PENICILLIN S/E A/E INTERVEN
S/E: ALLERGY, D/N, VOMIT, PAIN @ INJECTION A/E: BACTERIAL RESISTANCE, ALLERGIC, C.DIFF, RASH, PRURITUS, D/N, FEVER, DROWSY, ANAPHYLAXIS (ANGIOEDEMA, CIRCULATORY COLLAPSE, CARDIAC ARREST, NEPHROTOXICITY) INTERVENTIONS: SUPERIN, C/S, ALLERGIC TO 1 AND 2 DOSE
41
ANTIBACTERIALS CEPHALOSPORINS MED S/E A/E INTERVEN
CEFTIAXONE ALLERGIC TO PCN S/E: N/V/D, CLOTTING (BLEED)!!!! A/E: NEPHROTOXICITY, STEVENS, ANAPHYLAXIS, THROMBOCYTOPENIA GI I NCREASE GLUCOSE A NAPHYLAXIS N EPHROTOXICITY T HROMBOCYTOPENIA DRUG INTERACTIONS: ALCOHOL INTERVENTIONS: C/S, SUPER, WITH FOOD, HYPERSENSITIVITY!!
42
ANTIBACTERIALS MACROLIDES MED S/E A/E INTERVE
AZITHROMYCIN PCN SUB S/E: N/V/D, CRAMP, PHOTOSENS!!, HA, FATIGUE,DIZZY, ORAL CANDIDIASIS!! A/E: ANAPHY,SUPER,HEPATOTOXICITY!!!, STEVEN, BLOOD DYSCRASIAS INTERVENTIONS: C/S, LIVER DAMAGE, ANTACIDS 2 HRS BEFORE/AFTER!!!! (TAKEN AT SAME TIME DECREASES ABSORPTION), D DRUG INTERACTIONS: INCREASE DIGOXIN, CYCLOSPORINE, WARFARIN. DECREASE PCN
43
ANTIBACTERIALS GLYCOPEPTIDES MED S/E A/E INTERVEN
VANCOMYCIN!!!!! MRSA, PSEUDOMEMBRANOUS COLITIS CAUSED BY CDIFF S/E: N/V, DIZZY, SUPER, DISULFIRAM (ALCOHOL) A/E: OTOTOXICITY!!, NEPHRO!!,ANAPHY, BLOOD DYS, STEVEN, CDIFF - IV TOO FAST!!,HYPO,RED BLOTCH!!,TOXIC FONT- FLUSHING, OTO, NEPHRO, THROMBOPHLEBITIS INTERVENTIONS: C/S, 1-2 HR IV!!!,BP, RENAL TESTS (BUN AND CREATININE), HEARING
44
ANTIBACTERIALS TETRACYCLINES MED S/E A/E INTERVEN
DOXYCYCLINE!!!! S/E: N/V/D, PHOTOSE!!!, DISCOLORATION OR HYPOPOPLASIA OF TEETH!!!, STUNT GROWTH!!, NO KIDS UNDER 8, STOMATITIS, GLOSSITIS A/E: ANAPHYLAXIS, CDIFF,OTO!!!,HEPATO!!,NEPHRO!!!,PANCYTOPENIA, STEVENS DRUG FOOD INTERAC: MILK(DECREASE ABSO), ANTACIDS, BC!!!!!, PCN, AMINOGLYCOSIDES INTERVEN: C/S, KIDNEY AND LIVER, EMPTY STOMACH AND WATER!!!!!, SUNSCREEN, AVOID MILK, IRON, ANTACIDS (BAD ABSOR)!!! NONHORMONE BC (D)!!!
45
ANTIBACTERIALS AMINOGLYCOSIDES MED S/E A/E INTERVEN
GENTAMYCIN!!!! S/E: PHOTOSEN, SUPER, STOMATITIS, N/V, FEVER,LETHARGY A/E: ANAPHY,SEIZURES,OTO(HEAR)!!,NEPHRO(KID)!!, CDIFF, STEVEN MORE TOXIC INTERVENTIONS: C/S, HEARING LOSS AND RENAL, P AND T DRUG LEVELS, OTO-VERTIGO AND TINNITUS
46
ANTIBACTERIALS SULFONAMIDE MED S/E A/E INTERVENTION
TRIMETHOPRIM-SULFAMETHOXAZOLE (BACTRIM) URINARY TRACT ANTIINFECTIVE SYNERGISTIC S/E AND A/E: GI, STOMATITIS, PHOTOSEN,CRYSTALLURIA, RENAL FAIL,BLOOD DYS, STEVENS INTERVENTIONS: INCREASE FLUID 2000/DAY, CBC AND RENAL, RASH, SUPER, AVOID 3RD TRIMESTER!!!, AVOID ANTACIDS!!, SORE THROAT, BRUISING, BLEEDING!!! NO SUN
47
ANTIBACTERIALS FLUROQUINOLONES MED S/E A/E INTERVEN
CIPROFLOXACIN TREAT UTI S/E: RASH, N, HA, PAIN,V,DIZZY, CHANGE IN TASTE!!, DECREASE SLEEP!!, PHOTOSEN A/E: HEART DYSRHYTH (W OTHER DRUG)!!!, NEUROTOX,STEVENS, BLOOD GLUCOSE, TENDON RUPTURE!!!!!, PERIPHERAL NEUROPATHY!!! DRUG INTERAC: ANTACIDS AND MILK DECREASE ABSOR, INCREASE EFFECT OF ORAL HYPOGLYCEMICS INTERVENTIONS: C/S, HEART RATE AND RHYTHM, IV 60-90MIN, INCREASE FLUID MORE 2000/D, NO CAFFEINE, STOP DRUG IF THERE IS TENDON/JOINT PAIN!!!!!!!!, BG!
48
ANTIFUNGALS AZOLES MED INTERACTIONS DECREASE WHAT
FLUCONAZOLE (DIFLUCAN) !!! S/E: D/N/V, HA, SUN!!!, RASH A/E: HEPATOTOX, RENAL TOX, HYPOKALEM, RASH DECREASE METABOLISM OF MEDS!!! (DRUG STAY IN BODY =S/E) NO ALCOHOL, GRAPEFRUIT
49
ANTITUBERCULAR DRUG - ISONIAZID S/E? A/E?
S/E: DROWSY, TREMORS,PHOTOSEN,TINNITUS, N/V,DRY MOUTH, C A/E: PERIPHERAL NEUROPATHY!!!!!!, HEPATOTOX,PSYCHOTIC, SEIZURES, OPTIC NEUROPATHY(VB6), BLOOD DYS, THROMBCYTOPENIA, HEPATITIS!! INTERVENTIONS: 1 HR BEFORE OR 2 HR AFTER MEALS!!!, COLLECT IN AM, PYRIDOXINE (VB6) PREVENTS PERIPHERAL NEUROPA!!!!!!, EYE EXAMS, NUMB, TINGLING, BURNING, AVOID ANTACIDS
50
ANTI TB - RIFAMPIN S/E? A/E?
INHIBITS ENZYME NEEDED FOR PROTIEN SYNTHESIS S/E: STOMACH PAIN, URINARY RETENTION, RED ORANGE PEE!!!!!!! A/E: LIVER TOX, N/V, RASH
51
ANTI TB - ETHAMBUTOL BACTERIO???? S/E? A/E?
BACTERIOSTATIC = INHIBITS CELL WALL SYNTHESIS S/E: INCREASE URIC ACID!!!! A/E: HEPATOTOX, OPTIC NEUROPATHY, OPTIC NEURITIS (RED AND GREEN)!!!!!!
52
ANTI TB - PYRAZINAMIDE (PZA) S/E? A/E?
S/E: INCREASE URIC ACID, ACHES, PAIN, PHOTOSEN, ACNE A/E: LIVER TOX
53
HIV AND AIDS NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS (NRTIs) PATIENT TEACH
ZIDOVUDINE PREVENTS VIRAL DNA SYNTHESIS TREAT WITH COMBINED DRUGS PREVENTS MATERNAL HIV TRANSMISSION + POST EXPOSURE PROPHYLAXIS S/E: N/V/D, ANOREXIA, C, HA, DIZZY, NEUROPATHY, RASH, LIPOATROPHY, MALAISE A/E: DECREASE BONE MARROW (ANEMIA, NEUTROPENIA), HEPATOTOX, NEUROTOXI, PANCREATITIS STORAGE OF MEDS RECORDING SHEET FOOD AND FLUID
54
GI - ANTIEMETICS DOPAMINE ANTAGONISTS PROMETHAZINE (PHENERGAN) MED? INHIBITS? USES? S/E? A/E?
BLOCKS DOPAMINE INHIBITS V USES: N/V, CHEMO, RADIATION S/E: DRY MOUTH, SEDATION, C, ORTHO HYPO, TACHY A/E: EPS WITH INCREASED THERAPY (PARKINSONS)
55
GI - ANTIEMETICS SEROTONIN ANTAGONISTS ONDANSETRON (ZOFRAN) INCREASE EFFECT W? USES? S/E?
BLOCK VAGAL NERVE INCREASE EFFECT WITH DEXAMETHASONE USES: POSTOP, CHEMO S/E: HA, DIZZY, HYPO,PALPITATIONS, CONSTIPATION,EDEMA, FATIGUE
56
GI - ANTIEMETICS METOCLOPRAMIDE (REGLAN) BLOCKS? INCREASE DOSE? S/E?
BLOCKS DOPAMINE POSTOP EMESIS, CHEMO, RADIATION INCREASE DOSE: SEDATION, FATIGUE S/E: DROWSY, FATIGUE, HA, C, URINARY RETENTION, BLUR, TACHY, EPS
57
GI - LAXATIVES OSMOTIC (SALINE) LAXATIVES MED? PULLS WHAT? S/E?
MAG SALTS-MAG HYDROXIDE (MILK OF MAGNESIA) MAG CITRATE PULL WATER INTO COLON WATERY STOOL BOWEL PREP FOR SURGERY S/E: FLUID AND ELECTROLYTE IMBALANCE, CRAMPS, N/V, FARTS, D LACTULOSE MANAGE HEPATIC ENCEPHALOPATHY DECREASE BLOOD AMMONIA!! IMPROVE MENTAL S/E: FART, D, CRAMPS, V/N
58
GI LAXATIVES STIMULANT LAXATIVES MED? TREATS? S/E? A/E?
BISACODYL (DULCOLAX) OPIOID CONSTIPATION TREAT CONSTIPATION S/E: DIZZY, CRAMP, N/D, K AND CA IMBALANCE, RED AND BROWN URINE!!!!! A/E: OVER USE LEADS TO DECREASED TONE AND SENSATION
59
GI LAXATIVES BULK FORMING LAXATIVES MED? ABSORB? A/E?
PSYLLIUM (METAMUCIL) ABSORB WATER INTO INTESTINE SHORT TERM, IBS, ILEOSTOMY, COLOSTOMY A/E: DECREASE FLUID = OBSTRUCTION MIX WITH WATER, STIR, FOLLOW W WATER
60
GI LAX EMOLLIENTS (LUBRICANTS AND STOOL SOFT) MED? PREVENT?
DOCUSATE SODIUM (COLACE) INCREASE WATER ACCUMLATION PREVENT CONSTIPATION AND DECREASE STRAINING
61
ANTI ULCER HISTAMINE H2 BLOCKERS MED? S/E?
FAMOTIDINE (PEPCID) DECREASE GASTRIC ACID, HEAL ULCERS S/E: ERECTILE DYS, DECREASED B12 30 MIN BEFORE MEALS OR AT BED NO NSAIDS NO OTC
62
ANTI ULCER PROTON PUMP INHIBITORS ENDING?? 3 PS? STOOL?
“PRAZOLE” MOST POWERFUL DECREASE GASTRIC ACID INHIBITING H/K ATPase PREVENT HOLES, POROUS BONES, POSSIBLE GI INFECTION (CDIFF)!!!! 30 MIN BEFORE MEALS IN MORNING BLACK TARRY STOOL!!!!! D, ABD PAIN, HA
63
ANTI ULCER ANTACIDS WHAT? DONT? SCAM?
NEURTALIZE ACIDITY RELIEVE HEART BURN DECREASE GERD DONT MIX!!! 1 HR BEFORE MEDS DRINK WATER SodiumbCalciumcAluminumhMagh- ALKA SELTZER, TUMS, AMPHOGEL, MAALOX
64
U RESP ANTIHISTAMINES (1ST) MED? CROSSES?
DIPEHHYDRAMINE (BENADRYL) BLOCKS HISTAMINE CROSSES BLOOD BRAIN EASIER PREGO-AVOID- DECREASE MILK
65
U RESP ANTIHISTAMINES (2ND) FEW? MEDS?
FEW S/E WORKS PERIPHERALLY
66
U RESP NASAL DECONGESTANTS MED? FREQUENT USE??
STIMULATE ALPHA ADRENERGIC CONSTRICTION = DECREASE SECRETIONS FEW S/E OXYMETAZOLINE (AFRIN) FREQUENT USE=REBOUND CONGESTION!!!!!
67
U RESP SYSTEMIC DECONGESTANTS - ALPHA ADRENERGIC AGONISTS SHORT OR LONG? USE? INCREASE? MEDS?
RELIEVE CONGESTION LONG TIME!!! ALLERGIC RHINITIS INCREASE BP AND GLUCOSE!!! PSEUDOEPHEDRINE (SUDAFED) PHENYLEPHRINE HYDROCLORIDE
68
U RESP ANTITUSSIVES SUPPRESS???
SUPPRESS COUGH BENZONATATE (TESSALON) CODEINE DEXTROMETHORPHAN (BENYLIN) HYDROCODONE IN BREASTMILK
69
U RESP EXPECTORANTS MED? LOOSENS?
GUALFENESIN (MUCINEX) LOOSEN SECRETIONS COUGH TO CLEAR
70
L RESP BRONCHODILATORS - SYMPATHOMIMETICS SELECTIVE BETA 2 ADRENERGIC AGONISTS
ALBUTEROL INCREASE BP,HR,VASOCONSTRICTION, DECREASE RENAL AND GI BLOOD SHORT ACTING S/E: TREMOR
71
L RESP BRONCHODILATORS METHYLXANTHINES
THEOPHYLLINE LOW TI AND NARROW RANGE (5-15)!!!!! TOXIC HEART PROBLEMS NOT FOR PTS W SEIZURES!!! NO COFFEE USE IF OTHER DRUGS DONT WORK
72
ENDOCRINE TH REPLACEMENT DRUGS (LIFE LONG)
LEVOTHYROXINE SODIUM (SYNTHROID) SYNTHETIC THROXINE (T4) TO T3 HYPERTHYROIDISM EFFECTS (TACHY, TREMOR, ANGINA, INSOMNIA, HEAT INTOLERANCE, HTN, INCREASED POOP, WEIGHT LOSS, N/V A/E: MI, HF, SEIZURES, PALPITATIONS FIBER- DECREASE ABSORPTION MONITOR PULSE,VS, WEIGHT
73
ENDOCRINE THYROID SUPPRESSING DRUGS
PROPYLTHIOURACIL (PTU) BLOCK THYROID PEROXIDASE BLOCKS T4 TO T3 S/E= ARGANULOCYTOSIS AND RASH, HEPTATOTOXICITY CHECK BEFORE- LIVER CHECK AFTER- BLOOD COUNTS AND JAUNDICE W MEAL OKAY 1ST TRIMESTER
74
ANTI DM TYPE 2 SECOND GENERATION SULFONYLUREAS 2 MEDS
GLIPIZIDE (GLUCOTROL)! INCREASE INSULIN CONTROL HYPERGLY HYPOGLY - ALCOHOL SLOW 1-2 DAILY OK BREATFEED MEGLITINIDES! NATEGLINIDE (STARLIX) AND REPAGLINIDE (PRANDIN) INCREASE INSULIN CONTRAINDICATED: LIVER DISEASE CAUSE HYPOGLY SHORTER BURSTS!!!! 15-30 MIN BEFORE MEAL > 10 YRS
75
ANTI DM BIGUANIDES
METFORMIN (GLUCOPHAGE) DECREASE GLUCOSE INCREASE INSULIN SENSITIVITY N/V/D, INGESTION, ABD PAIN DOESNT CAUSE HYPOGLY >10 YRS OK BREAST IODINATED CONTRAST MEDIA INCREASE RISK OF RENAL FAIL AND LACTIC ACIDOSIS (HOLD 48 HRS) !!!! NO ALCOHOL
76
TRANSPLANT GOAL OF IMMUNOSUPPRESSION
DECREASE PATIENT'S RISK OF REJECT DECREASE S/E, INFECTIONS, MALIGNANCY
77
TRANSPLANT INDUCTION
GIVEN AT TIME OF TRANSPLANT FOR SHORT DURATION NEUTRALIZE AND DEPLETES TCELL
78
TRANSPLANT MAINTENANCE
LONG TERM FOR LIFE OF GRAFT
79
TRANSPLANT CYCLOSPORINE
CALCINEURIN INHIBITORS SUPPRESS ACTIVATION OF T LYMPHOCYTES PO BID SAME TIME DAILY MORNING DOSE AFTER BLOOD DRAW DONT CRUSH A/E:HTN, NEPHRO, ACUTE RENAL FAIL, INCREASE K, DECREASE MG, NEUROTOX, GINGIVAL HYPERPLASIA , HIRSUTISM MONITOR: TROUGH, ELECTROLYTES, RENAL FUNCTION, BP, NO GRAPE
80
VACCINES VARICELLA VACCINE
PREVENT CHICKEN POX first dose 12-15 months, second 4-6 yrs CI: ANAPHYLAXIS TO VACCINE, GELATIN, NEOMYCIN, PREGNANCY NO IMMUNOCOMPROMISED S/E: PAIN AND RED AT INJECTION, FEVER, CHICKEN POX LIKE RASH A/E: ANAPHYLAXIS, THROMBOCYTOPENIA, ENCEPHALITIS, STEVENS
81
ANTICANCER ALKYLATING AGENTS CYCLOPHOSPHAMIDE
DAMAGE CELLS DNA PREVENT REPRODUCTION OF CANCER CELLS ASSESS FOR HEMATURIA CARDIOTOXICITY MYLEOSUPPRESSION PEE 2-3 HRS SUN LOW PURINE NO ACID
82
ANTI CANCER ANTITUMOR ANTIBIOTICS DOXORUBICIN
INTERFERE WITH DNA REPLICATION AND RNA TRANSCRIPTION PPE AVOID PEE AND FLUIDS (5 DAYS AFTER TREAT) S/E: BONE MARROW SUPPRESSION, N/V, CARDIOTOXICITY!!!!, RADIATION RECALL, ALOPECIA, STOMATITIS/MUCOSITIS, INFERTILITY, TACHY, HF URINE PINK LIPOPHILIC: REDUCED CLEARANCE IN OBESE NO TURMERIC (DECREASE EFFECTS)
83
ANTICANCER PLANT ALKALOIDS
BLOCK CELL DIVISION IN M PHASE VINCA ALKOLOIDS (PERWINKLE PLANT) - VINCRISTINE TAXANES (YEW TREE) - PACLITAXEL, DOCETAXEL DOSE LIMITING NEUROTOX!! (PERIPHERAL NEUROPATHY) A/E:HYPERSEN, SENSORY LOSS, PARESTHESIA, GAIT, MUSCLE, N/V, ALOPECIA, C, NEUTROPENIS CHECK DTR
84
REPRODUCTIVE COMBINED HORMONAL CONTRACEPTIVE
ESTROGEN AND PROGESTIN STRENGTH OF ESTROGEN TYPE OF PROGESTIN ESTROGEN INHIBITS OVULATION PROGESTIN SUPRESS LUTEINIZING HORMONE HIGH ESTROGEN = VENOUS THROMBOEMBOLISM, MI, STROKE
85
REPRODUCTIVE CLOMIPHENE CITRATE
INDUCTION OF OVULATION S/E: HA, DIZZY, TIRED, DEPRESSION, ANXIETY, GYNECOMASTIA, HOT FLASH, DECREASED EYE, OVARY HYPERSTIMULATION , ECTOPIC

PHARM (16 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions