ANTIDEPRESSANTS

Question 1

TRICYCLIC ANTIDEPRESSANTS (TCAS)

Answer 1

LINES, MINES, IN
BLOCK REUPTAKE OF NORE AND SERO
BLOCK HISTAMINE

INCREASE MOOD, INTEREST
DECREASE INSOMNIA
INCREASE CNS DEPRESSION: ALCOHOL, SEDATIVES, HYPNOTICS, BARBITUATES

S/E: SEADTION, DIZZY, DECREASE VISION, DRY MOUTH/EYES, URINARY RETENTION, CONSTIPATION, WEIGHT GAIN, DECREASE GI AND SEX

A/E: ORTHO HYPO, DYSRHYTHMIAS, EPS, BLOOD DYSCRASIAS (LEUKOPENIA, THROMBOCYTOPENIA, ARGANULOCYTOSIS)

Question 2

SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS)

Answer 2

BLOCK REUPTAKE OF SEROTONIN
MAJOR DEPRESSIVE, ANXIETY, OCD, PANIC, PHOBIAS, PTSD

INCREASE CNS WITH ALCOHOL

S/E: HA, NERVOUS, RESTLESSNESS, INSOMNIA, TREMORS, SEIZURES, DECREASE GI AND SEX, SUICIDE, SEROTONIN SYNDROME

Question 3

SSRIs MED?

Answer 3

FLUOXETINE (PROZAC)

Question 4

SEROTONIN - NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIs)

Answer 4

INHIBIT REUPTAKE OF SEROTONIN AND NORE, NERVE FIBERS

MAJOR DEPRESSION, GENERAL ANXIETY AND SOCIAL

Question 5

SNRIs MED?

Answer 5

VENLAFAXINE (EFFEXOR)

S/E: DROWSY, DIZZY, INSOMNIA, HA, EUPHORIA, AMNESIA, BLURRED VISION, PHOTOSENSITIVITY, DECREASE EJACULATION

A/E: O HYPOTENSION, HTN, ANGIOEDEMA, BLOOD DYSCRASIAS, SUICIDE, STEVEN JOHNSON

+ ST JOHNS WORT = RISK OF SEROTONIN SYNDROME

Question 6

MONOAMINE OXIDASE INHIBITORS (MAO-Is)

Answer 6

DECREASE EFFECT OF MONOAMINE OXIDASE (INACTIVATES NORE, DOPA, EPINE, SERO)

DRUG INTERACTION: VASOCONSTRICTORS AND COLD MEDS (PHENYLEPHRINE AND PSEUDOEPHEDRINE) = HTN CRISIS

FOOD INTERACTION: TYRAMINE = HTN CRISIS

S/E: O HYPOTENSION, INSOMNIA, ANTICHOLINERGIC AFFECTS

INCREASE BP AND HR