ANTI FUNGALS (EXAM 3)

Question 1

POLYENES

MED??
TOXIC??
PRETREAT??

Answer 1

AMPHOTERICIN B (AMPHOCIN!!!!)

BINDS TO FUNGAL CELL MEMBRANE, LEAK OF CONTENTS

NEPHROTOXC (MONITOR UO,BUN,CREATININE, INCREASE FLUIDS)

PRETREAT TO AVOID REACTIONS WITH ACETAMIN,DIPHENHYYDRA, HYDROCORTISONE

GOOD FOR SYSTEMIC!

Question 2

AZOLES

MED?
S/E?
A/E?
DECREASE WHAT?

Answer 2

FLUCONAZOLE (DIFLUCAN) !!!

S/E: D/N/V, HA, SUN!!!, RASH

A/E: HEPATOTOX, RENAL TOX, HYPOKALEM, RASH

DECREASE METABOLISM OF MEDS!!!