Final Flashcards
Indications
Reasons for giving a drug to a patient
Contraindications
Reasons for not giving a drug to a patient
Prescription (legend) drug
Drug that is regulated by the FDA due to having the ability to cause serious harm if not used in an appropriate manner
Conditions for valid VCPR
- Vet must assume responsibility for making clinical judgments
- Must have recently seen the animal and know its care
- Must be available for follow-up care
Regimen
Plan for administering drugs
Drug regimen consists of:
Kind of drug
Route of administration
Dosage
Frequency
Duration
Pharmacokinetics
Complex series of events that occurs once a drug is administered to the patient
Influences by the manner in which the drug is given
Some routes have limitations
Oral (PO)
By mouth
Contraindicated for animals with nausea/vomiting
Some taste horrible
Intravenous (IV)
Given in the vein
Takes effect almost immediately
Doesn’t last as long as drugs administered by other routes due to body eliminating drug rather quickly
Intramuscular (IM)
Given in the muscle
Sometimes painful
Absorbed more slowly than IV but faster than SQ
Subcutaneous (SQ or SC)
Given in tissue beneath the skin
Take longer to absorb than IV or IM
Intradermal (ID)
Given into the skin
Used for testing for allergies
Intraperitoneal (IP)
Given into the abdominal cavity
Intraarterial (IA)
An injection given into the artery
Intraarticular (IA)
An injection given into the joint
Intracardiac (IC)
An injection given into the heart
Used mostly for humane euthanasia and cardiopulmonary resuscitation (CPR)
Intramedullary
An injection given into the bone marrow cavity
Epidural/subdural
An injection given into the spine or near the spine
Nebulizer
Drug that can be inhaled in a fine mist
Antibiotics or bronchodilators can be inhaled into deep, small airways
Metered-dose inhaler
Administered by using a hand-held device that fits over an animal’s nose and mouth
Anesthetic gases
Gaseous forms given with vaporizers
Transdermal (topical)
Drugs that are placed on the skin
Gloves should always be worn when handling these drugs
Concentration Gradient
Drugs that move from one compartment of the body to another
Move from areas of high concentration to lower concentration
Bioavailability
Measures the amount of drug that gets absorbed and is available to the patient
Water-soluble drugs
Dissolve in water
Tend to stay in the bloodstream where they can be bound to various proteins (albumin) or can stay free
Lipid-soluble Drugs
Absorbed by bodily fats such as lipids
Tend to move out of the bloodstream into the interstitial fluid
Fat, liver, kidneys, and bone may act as storage sites for these drugs
What 2 body structures may interfere with the absorption of certain drugs
Placenta and blood-brain barrier
How are drugs excreted?
Removed primarily through the liver via bile or through the kidneys via urine
May also be excreted through the mammary glands, the lungs, the GI tract, sweat glands, saline, or through the skin
Residues
Drugs that appear in the animal’s milk or meat products
Can cause allergic reactions in people, antibiotic resistance, and also cause some cancer in humans
Pharmacodynamics
Study of Mechanisms by which drugs produce physiological changes in the body
Drugs combine with parts of the cell membrane or with internal parts of the cell to cause changes in how the cell functions
Drugs may increase or decrease the activities of specific cells or tissues
Efficacy
The degree to which a drug produces its desired effect
Once the efficacy level of a drug has
been reached, giving more of the drug won’t produce more effect
Potency
the amount of drug needed to produce the desired effect and is represented by a dose on a
dose-response curve
Lethal Dose (LD50)
the dose of the drug that’s lethal to 50% of the animals given that drug
Effective dose (ED50)
the dose of a drug that produces the desired effect in 50% of the animals given that drug
Therapeutic Index
LD50/ED50
Adverse Drug Reaction
Any undesired response to a drug
Formulary
A book that contains drug dosages and a listing of adverse reactions
Drugs are most commonly classified as __________ or _________
Proprietary (trade name of a patented drug)
Generic (unpatented copy of a drug)
Drug labels on drugs must contain the following:
Drug names (both generic and trade names)
Drug concentration and quantity
Name and address of the manufacturer
Controlled substance status
Manufacturer’s control or lot number
Drug expiration date
Environmental Protection Agency
Regulates the development and approval of animal topical pesticides
Drug Enforcement Agency
Concerned with the regulation of substances that have potential for human abuse
The DEA requires all those who dispense such drugs to be licensed and to keep careful records of all such drugs. Documentation should include the following:
Date of prescription
Owner and patient name
Drug name
Amount dispensed and strength of the drug
Initials of dispensing doctor
United States Department of Agriculture (USDA)
Regulates the development and appropriate biologics (medical products such as vaccines, serums, antitoxins,antibodies, and other products)
The Animal Medicinal Drug Use Clarification Act (AMDUCA)
made the extra label use of approved veterinary drugs legal under certain well-defined conditions
This is an important law
To get a drug labeled for a specific use in a specific animal costs a lot of money
List 6 Rights of Administration
Right patient
Right drug
Right dose
Right route
Right time and frequency
Right documentation
Oral medications come in what forms
Tablets
Suspensions
Capsules
Emulsions
milky solutions containing the drug the mixtures don’t mix so it needs to be shaken
Elixirs
compound liquid medications held in solution by alcohol
contains flavoring and sweeteners to help mask the taste of the drug
What ways can oral meds be administered?
Administering oral medications can be done with pill guns, a speculum (a tool placed inside a bodily cavity opening to insert a medicine), a stomach tube, syringes, or with your hands,
List 4 types of syringes
- Slip tip – most common in vet med
- Luer lock - have a screw top that secures the needle to the syringe, excellent for injecting thick fluids because they don’t allow the needle to separate from the syringe under pressure
- Eccentric tip - used when injecting larger volumes (greater than 20 ml) into a vein, the hub of the syringe allows you to place a large syringe parallel to the vein you’re trying to inject
- Catheter tip – good for oral feedings or for feeding with catheters
Uses of IV catheters
Good for repetitive IV meds and allows for repeated injections
Butterfly catheters
Used for short-term IV therapy
Endotracheal tubes
are placed into the trachea (tubes that air goes through towards the animal’s lungs) for controlled ventilation (such as with CPR) or for use with anesthesia machines
Tranquilizers
Used to calm or quiet a patient
Phenothiazine tranquilizers
Produce sedation without significant analgesia
Ex. Acepromazine or chlorpromazine
Neuroleptanalgesics
Agents are a combination of an opioid and a tranquilizer
They produce a state of reduced awareness and analgesia in which the patient may or may not remain conscious
Useful for restraint, diagnostic procedures, as a preanesthetic, or for minor surgical procedures
Behavioral Pharmacotherapy
The use of drugs to treat various behavioral problems such as separation anxiety, phobias, compulsive disorders, or cognitive dysfunction syndrome
Have to be combined with environmental and behavioral management
Anti-anxiety Medications
Help relieve anxiety in animals
Side Effects: lethargy, ataxia, polyuria, polydipsia, hyperexcitability, and liver problems
Ex. Diazepam, Alprazolam, Sileo
Antidepressant Medications
used in veterinary medicine to treat a variety of obsessive disorders and medical conditions by blocking reuptake (reuse) of norepinephrine and serotonin in the brain
Side effects : sedation, tachycardia, mydriasis (overstretching of the eye’s pupil), dry mouth, urine
retention, and constipation
Ex. Amitriptyline, Trazodone, Fluoxetine, and Selegine
Serotonin-reuptake Inhibitors
Increase the amount of serotonin in the brain by preventing serotonin removal
Side effects: anorexia, nausea, lethargy, anxiety, and diarrhea
Ex. Fluoxetine
Monoamine oxidase-B inhibitors
Allow dopamine levels to increase and is used to treat old dog dementia and canine Cushing’s
Side Effects: vomiting, diarrhea, anorexia, restlessness, and shaking
Ex. Selegiline
Inotropic Drugs
Affect the force/strength of a heart contraction
Positive inotropic drugs improve the strength
Ex. Dobutamine and Pimobendan
Negative inotropic drugs decrease the strength
Chronotropic Drugs
Affects the heart rate
Positive chronotropic increases the heart rate
Ex. Atropine, dopamine, epinephrine
Negative chronotropic decreases the heart rate
Ex. Metoprolol and digoxin
Emetics
Drugs that cause vomiting
Used in treatment of poisonings and drug overdoses
Ex. Apomorphine, Xylazine, and Hydrogen Peroxide
Antiemetics
Drugs that help control or prevent vomiting
Ex. Acepromazine, Metoclopramide, Meclizine, Ondansetron, and Maropitant citrate
Hematinics
Iron supplements that help correct anemia
Ex. Iron supplements, androgens, and erythropoietin
Anticoagulant
Stop clot formation
Ex. Heparin, EDTA
Laxatives
Medications that help stimulate bowel movements
Ex. Lactose, Metamucil, Cat Lax
Antacids
Neutralize the stomach acid by binding directly to it which contains aluminum, calcium, and magnesium salts
Ex. Ranitidine, Famotidine, omeprazole, sucralfate
Antitussives
Suppress or inhibit coughing
Best for non-productive coughing
Ex. Butorphanol, Hydrocodone Bitartrate, and Temaril-P