fever, pain, inflammation

Question 1

NSAIDs

Answer 1

inhibition of prostaglandin synthesis
block of the enzymes COX 1 and 2
rapidly absorbed from the GI tratc
the peak is 1-3 hours
metabolized by the liver
excretion in the urine
cross placenta
found in breast milk

Question 2

1st generation

Answer 2

block both COX 1 many cells GI
COX 2 - inflammation

Question 3

2nd generation

Answer 3

NSAIDS block only COX 2

Question 4

acetaminophen

Answer 4

acts directly on the thermoregulatory cells of the hypothalamus to produce antipyresis - may work peripherally to block pain impulse generation, may also inhibit prostaglandin synthesis in the CNS
used to treat pain and fever
headache, rash, hives, angioedema, hepatoxicity, liver failure

Question 5

morphine

Answer 5

narcotic agonists
binds to the MU receptors in brain
analgesia used off label for dyspnea in left vent failure
CNS depression, resp depression, GI slowed motility, and constipation
assess pain, vital signs resp rate and constipation