Female Reproductive System Flashcards

1
Q

What are the 3 layers of the uterus

A

Endometrium - lining of uterus

Myometrium - contain 3 smooth muscle layers

Perimetrium

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2
Q

Function of cervix

A
  1. Maintains sterility of structures above it. Prevents bacterial invasion
    • narrow external os
    • thick cervical mucus
    • shedding endometrium
  2. Guides passage of sperms to the uterus.
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3
Q

Where are the Bartholian’s gland ?

A

Either side of the vaginal opening

Other name - great vestibular gland

Secrete lubricant fluid during intercourse goes down the great vestibular duct.

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4
Q

Where are the Skenes glands located ? What is it ?

A

Either side of urethra.

Parautheral gland- another name

Secrete mucus during intercourse

Homologous with male scrotum

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5
Q

What nerve supplies the external genitalia and perineum?

A

Puodenal nerve - branch of sacral plexus

Origins - nerve root S2 ,3 and 4

Motor function - innervation of pelvic floor muscles

                             E.g . Levator ani muscles includ
                                      Ilioccocygeus 
                                      Puboccocygeus
                                      Puborectalis 

Innervation of external anal sphincter ( inferior rectal nerve - branch of puodenal nerve. )and external urethral sphincter . Prevent incontinence.

Sensory - provides innervation to external genitalia.

S2, S3 ,S4 , KEEP POO AND WEE OF THE FLOOR AND GENITALIA .

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6
Q

Clinical significance of the nerve that supplies pelvic floor , external genitalia etc.?

A

Puodenal nerve block

Anaesthesia for minor vaginal surgeries e.g . Episiotomy.

Puodenal nerve accompanied by internal puodenal artery so need aspirate ( withdraw fluid - check there is no blood) so that the drug is not given into systemic circulation.

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7
Q

What are the sphincter which are involved in urination in females ?

A

External urethral sphincter

Compressor urethrae - wraps around urethra and contracts pressing urethra against vagina

Urethrovaginalis - wraps around urethra - contracts - compress urethra against vagina.

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8
Q

What are the spaces in the female peritoneal cavity?

A

Vesicouterine - space byw posterior wall of bladder and anterior wall of uterus

Pouch of Douglas / rectouterine pouch - btw posterior wall of uterus and rectum

Made by relections of peritoneum

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9
Q

Normal position of uterus and abnormal positions?

A

Normal - anti - flexed , anti - verted

Abnormal - retroverted , retroflexed, ante verted

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10
Q

What is Pelvic organ Prolapse?

A

0 1 or more of the organs of the Pelvis move out of position and bulge into the vagina.

4 stages with increasing severity

  1. Stage 1 - more than cm above hymen
  2. Stage 2 - Btw 1cm above or below hymen
  3. Stage 3 - More than 1cm below Hymen but 2cm shorter than total vaginal length
  4. Complete eversion - bascially inside out , uterus etc on the outside of the body.
  5. Stage 2 -
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11
Q

Different types of Prolapse ?

A

Cystocele - Anterior prolapse ( Bladder prolapses, dropping and pushes on the wall of the vagina.

  1. Rectocele - (posterior wall prolapse) Bulging of anterior wall of rectum into the posterior wall of the vagina.
  2. Uterine prolapse - Uterus slips down into vagina and protrudes out of it.
  3. Vaginal Vault prolapse - The vault (top of vagina ) drops from normal position and sags down. (can happen after hysterectomy)

Enterocele - Small intestine drops into pelvic cavity and presses on the top of vagina creating a bulge.

Urethocele - Urethra drops down into vagina.

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12
Q

Causes of Pelvic floor prolapse ?

A

weakened pelvic floor , so organs sag. Caused by :

Increased pressure on pelvic floor :
       - pregnancy 
             * the more 
               children 
               you have 
               the more 
               at risk 
               you are 
   - overweight
   - Chronic 
     constipation. 
   - Chronic 
     cough e.g 
     asthma , 
     COPD 

Reduced tissue collagen - White women more at risk of prolapse than black as they have weaker/ less collagen - genetic (things like marfan etc effect collagen )

  • Hysterectomy - removal of uterus
  • Heavy lifting.
  • Age - menopause

more at risk -People with:
0 marfan ,

0 Joint hyper-mobility syndrome

0 Ehlers - Danlos syndrome - group of rare group of disorders that affect connective tissue.

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13
Q

Symptoms of Pelvic organ prolaspe ?

A

Pelvic or vaginal fullness - feel heaviness around lower tummy and genitals.

  • sensation of organs falling out (of vagina )
  • Bulging of organs into vaginal canal or through vaginal opening
  • Stress incontinence - leaking of pee when cough , squeeze
    • can have obscured stress incontinence )
  • problems peeing - need to go to the toilet more often , or bladder not emptying fully (some urine left).
Rectocele 
     0 incomplete 
        defacation - 
            * Ask 
              patient 
              do you 
              need to 
              put you 
              fingers in 
              you 
              vagina to 
              promote 
              pooing 
              /bowel 
               motion?

0 Constipation

  • certain prolapses can result in urinary retention (cant pass urine ) and can cause kidney infection / damage which can lead to kidney failure.
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14
Q

How do you assess someone with suspected Prolapse ?

A

Assessment

 - History 
 - BMI  
 - Abdominal 
  and Vaginal 
  examination
       0 Assess 
          degree of 
          prolapse 
          using 
         POP - Q - 
        pelvic 
        organ 
        prolapse 
    quantification 
       system. 

      0 Assess activity of pelvic floor muscle -  bi-manual examination squeeze - insert a finger and ask them to squeeze around them.  * some women stay they have been doing pelvic floor exercises but the squeeze test shows they are not doing it properly. 

0 rule out pelvic mass or other pathology.

0 Assess vaginal atrophy.

Prolapse assessment 
   - maximal 
     valsalva 
- sims speculum 
- lithotomy position - lying on back , knees bent at 70 dg - knees supported
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15
Q

Management of Prolapse ?

A

Conservative - fix cause
0 lose weight -
if overweight
(from BMI) - greater than 30kg/m2

0 chronic
cough - refer
to respiratory
specialist ?

0 Physiotherapy

 - pelvic floor 
 exercises.  

0 Chronic constipation - laxatives.

0 Miminse heavy lifting.

Pessaries
- many different types of pessary device - used for different types and severity of prolapse.

  • Surgical

lifestyle changes and pessaries encouraged / used before surgery is considered.

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16
Q

Surgical treatment of certain types of prolapse ?

A

Rectocele - posterior wall prolapse - posterior wall repair without mesh.

Posterior vaginal repair - tighten the support tissues at the back of the vagina. (the thin tissue btw rectum and vagina has weakened causing the prolapse. )

Uterine prolapse / vaginal vault- Hysterectomy
- uterus sparing surgeries -
0 Vaginal sacrospinous fixation - top of vagina stitched to a ligament of the pelvis on one side of the body
* vagina no longer straight , goes towards the stitched side - can cause pain during intercourse (dyspareunia)

vaginal sacrospinous hysteropexy - the cervix is stitched to a sacrospinous ligament in the pelvis - stitches inseted through cut in vagina

if mesh is used to hold it in place - called Laparoscopic sacro-hysteropexy (using keyhole surgery - uterus lifted up at fixed t bone at the bottom of spine.

Manchester repair neck of the womb (the cervix) is shortened; it involves shortening the cervix (neck of the womb) and supporting the womb in its natural position) .

Anterior prolapse - anterior repair without mesh

17
Q

How do surgical treat Vaginal vault prolapse?

A
  • vaginal sacrospinous hysteropexy

- Laparoscopic sacro-hysteropexy

18
Q

How should surgeries for prolapse be followed up?

A

6-month review after surgery

  • if mesh used check for mesh exposure.
19
Q

What is pessary ?

A

prosthetic device inserted into the vagina to support internal structures.

many types e.g ring , gellhorne etc.

problems

  • need to change every 3 months
    * some patients forget e.g dementia - skin can grow around it becomes hard to take out (impaction).
  • can fall out - if not inserted well or wrong type/ size
  • vaginal discharge or vaginal ulceration
20
Q

What is genital warts ?

A

STI - sexually transmitted disease.

  • Caused by HPV - Human Papilloma virus.
    • passed on by direct skin to skin contact during vaginal or anal sex.
      (not through kissing or sharing towels etc. )
  • Lumps / warts around vagina penis or anus.
    • common for appearance / reappearance of warts during pregnancy due to changes in the immune system.
21
Q

Management of Gential warts ?

A

refer to sexual health specialist :

  • vaginal speculum examination in women.
  • screening for other coexisting STI is essential (especially in under 25 )
  • Proctoscopy - (hollow tube used to inspect the inside of rectum ) - if patient engages in anal sex (receives it - anal receptive sex )
  • No need for sexual partner tracing if no other STI’s found.
  • if referral t sexual health not possible can be carried out in primary care but have to have the expertise to do these things.
    Same for treatment - but diagnosis of external genital warts should be confidently made.
22
Q

Treatment of Genital warts ?

A

First line for soft , non -keratinized lesion

  • Podophylltoxin - solution or cream
- Imiquimod - 
  for non and 
  keratinized genital 
  and perianal 
  (around anus) 
  warts. - no internal 
  use 
- Sinecatechin  10 % 
  ointment 
  external genital 
  warts aged over 18 
  and 
immunocompromised.  
  • These are self - applied creams - patient should be shown how to apply and how to locate warts. Cannot be used during pregnancy

Specialist appilication - TCA - Trichloroacetic acid
* first line along with Podophyllotoxin - for soft keritanized warts.

First line for kertinized warts.
Kertinized warts - respond well to :
- cyrotherapy -
freezing wart

- excision 
- TCA 
- electrocautery (removal of wart by burning via low - voltage electrified probe ) - anesthesia used * these are ablative therapies - removal / destruction of body part or tissue. 

NO TREATMENT
- sometimes treatment not indicated , can clear up within 6 months.

23
Q

What is Bartholin’s Cyst/ Duct cyst ?

A

Painful swelling in Bartholin’s gland.

Duct obstructed so fluid backs up into the gland.
* can be linked to STI or some bacterial infections - not always.

Abscess can form if cyst is infection and collection of pus develops.

Abcess - red , swollen, tender and hot. Patient may have a fever.

24
Q

Symptoms of Bartholin’s cyst ?

A

soft painless lump

  • if cyst grows - noticable and uncomfotable when walking , sit down or have sex.
  • pain in skin around vagina.

Abccess formation - red, hot , tender swollen. fever (38)

25
Q

Treatment of Bartholin’s cyst ?

A

If linked to bacterial infection - Antibiotic given (no further treatment may be needed )

Painful cyst

 - soak in warm water /warm compress several times a day for 10-15 mins.  - pain relief  - antibiotics 

Large, painful abcess - if not responded to treatment for painful cyst.
- Word balloon catheter insertion -

  1. small incision in abscess and drain fluid ,
  2. word balloon catheter ( thin tube with balloon at the end) fitted into empty cyst/abscess.
  3. Balloon filled with sterile fluid and increases in size filling cyst / Ab
  4. Catheter stays in for 3 -4 weeks and epithelialisation (new cells grow around it ) occurs.

Marsupialisation - for recurrent abscesses.

  1. small incision in cyst/ Abscess and fluid drained
  2. edges of surrounding skin sewed to create small kangaroo pouch to collect any further fluid draining - prevent abscess coming back.
  3. special gauze applied to prevent bleeding. Cut should heal by itself.
26
Q

What is Acne Inversa / hidradenitis suppurativa ?

A

Long term skin condition - very painful

  • boil- like lumps , areas of leaking pus, abscess scarring.

Can happen in groin / armpit - areas of apocrine sweat glands.
(around anus ,on bum and under breats can also be affected )

Blockage of aprocrine sweat glands - secretions cannot escape so tubes swell , burst or become infected.

Smoking and obesity worsen symptoms.

  • most common during puberty . less common before puberty and after menopause (can happen at any age tho)

Patient can also have acne and ingrown hairs. ( Acne inversa can be mistaken for these things )

27
Q

Treatment of Hidradenitis suppurativa.

A
  1. warm flannel , painkillers (NSAID) , antibiotics, surgery , steriod injection.
  2. Clindamycin - Antibiotic lotion given for affected skin - reduce spread of bacteria on the skin
  3. Oral Tetracycline - given as well to prevent further attacks
    • Doxycycline
    • lymecycline

After lack of response:
1. (Clindamycin + rifampicin ) - can also be given - Not tetracyclines

Clindamycin - linomycin class

Rifampcin - rifamycins

  1. Still no response
  • Acitretin - Vitamin A derivative - Retiniods
    • unclog pores allow other medicated cream in . prevent dead cells clogging pores.
      (NOT USED IN PREGNANT WOMEN )
28
Q

Acitretin and pregnancy and side effects , blood donation .

A

Do not g=take/ give if patient is pregnant or plans to become pregnant.

Can harm fetus

Patient needs to have 2 negative pregnancy results and has to be on 2 acceptable forms of birth control.
     * (not need if  
        patient has 
        has a 
      hysterectomy )
  • Do not consume anything that contains alcohol during treatment and 2 months after.
    • combines with alcohol forming a substance harmful to fetus - stays in blood for a long time.
  • men should talk to doctor if taking this medication and partner is pregnant or plans to be . A small amount of Aretretin can be found in semen but not known if it causes harm.

Do not give blood while on this.

Acitretin may cause liver damage

  • yellowing of skin ,eyes
  • dark urine
  • nausea , vomiting
  • pain in in upper right stomach.
  • loss of appetite

*report these symptoms to GP

Still no response
3. Adalimumab - (injection under skin) reduced inflammation - ANTI -TNF (tumour necrosis factor)

*if there is a reduction of more than 25 % in absecess and nodule count discontinue and give INFLIXIMAB - IV infusion (anti -tnf ) instead

No response

  1. Surgery - removal of affected areas
29
Q

St johns wort and hormonal contraceptives ?

A

St johns wart interferes with action of hormonal contraceptive.

30
Q

What are Ectopic pregnancies ?

A

Fertilised egg implants himself outside the wound.

usually happens in the Fallopian tubes.

  • can’t save pregnancy - medicine or operation to remove it.
31
Q

Symptoms of ectopic pregnancy ?

A

Missed period - usual of normal preg

Tend to develop btw 4th and 12th week .

  • tummy pain - low down on one side
    (e. g. right iliac pain with radiation down right thigh)
  • pain in tip of shoulder
  • vaginal bleeding / brown watery discharge
  • discomfort when pooing or weeing.
32
Q

Risk of ectopic pregnancy ?

A

Can cause fallopian tube rupture.

medical emergency - life threating

  • signs
    • sharp intense
      pain in tummy
    • very
      dizzing/fainting
    • sick , pale

Treatment

Surgery to repair fallopian tube.

33
Q

management of suspected ectopic pregnancy ?

A

Signs of haemodynamic instability - (perfusion failure characterised by circulatory shock and advanced heart failure )

   - Hypotension - Tachycardia  - Shock  - Pallor  - collaspe 
  • give IV fluids - emergency abulance transfer to hospital

If no need for abulance and transfer (no in immediate danger )

  1. arrange pregnancy test - urine .
  2. pregnancy confirmed - gentle abdominal exam
    • abdominal pain and tenderness strongly suspect
      ectopic pregnancy
      • no abdominal P or T do gentle pelvic exam - presence of Pelvic T or cervical motion tenderness ( chandlier’s sign - unpleasant sensation or response elicited by movement of cervix by clinicians hand) - indicative of inflammatory processes)
  3. Arrange immediate admission to early pregnancy unit or out of hours gynecology for diagnosis and treatment . (i f the tenderness and pain is present - either during abdominal exam or pelvic )
    * Pelvic exam -do not palpate for adnexal (adnexa of uterus - adjoining region to the uterus -Fallopian tube , ovary) mass or pelvic mass - increases risk f rupture of ectopic pregnancy.

Diagnosis - Transvaginal ultrasound - identify location of pregancy and whether there is a fetal pole and heartbeat.

MRI - second line diagnostic tool.

34
Q

Treatment of ectopic pregnancy?

A

Expectant management - watch and see if ectopic pregnancy is able to resolve itself with medication or surgery. Patients with minimal symptoms and clinically stable includ PUL (pregancy of unknown location)

Medical management - Drug treatment - Methotrexate .

1st line treatment for women who:
0 No significant pain.
   0 An 
    unruptured 
    ectopic 
    pregnancy 
    with an 
    adnexal mass 
    smaller than 
    35 mm with 
    no visible 
    heartbeat.

0 Serum hCG
level less
than 1500
IU/L.

     0 No 
        intrauterine 
        pregnancy 
        (as 
         confirmed 
         on an 
         ultrasound 
         scan).

And can follow up.

Surgery - Salpingectomy (removal of fallopian tube) or Salpingotomy (incision into fallopian tube to remove ectopic pregancy ) via laparoscopy (keyhole surgery in abdomen and peritoneum - small incision made in abdomen to allow surgeon to put laparscope inside and look at the inside of the tummy or by open surgery - (cutting the skin so that doctor has full view of structures , organs)

 1st line - if woman has :

0 Significant pain.

0Adnexal mass of 35 mm or larger.

0 Fetal heartbeat visible on an ultrasound scan.

0 Serum hCG level of 5000 IU/L or more.

and cannot attend follow up after methotrexate treatement.

Monitor Serum HCG 0 to see if it has gone down to acceptable level after treatment.

*Anti-D immunoglobulin is offered to all rhesus-negative women who have had surgical removal of an ectopic pregnancy.