Female Pathology, Ovary and Fallopian Tubes

Question 1

primary tumors of the fallopian tube are associated with mutations in what gene?

Answer 1

BRCA

Question 2

most common mass of the ovary

Answer 2

functional cysts

Question 3

ovarian surface epithelial neoplasms: what increases risk and what decreases risk?

Answer 3

increased risk: obesity, family history, germline mutation in tumor suppressor genes, nulliparity
reduced risk: high parity, use of oral contraceptives

Question 4

most common ovarian epithelial tumor

Answer 4

serous tumors

Question 5

malignant serous tumors of ovary: mutations in what genes are associated with low grade and which for high grade?

Answer 5

low grade: KRAS, BRAF, ERBB2

high grade: p53

Question 6

histology of ovarian serous cystadenocarcinoma

Answer 6

psammoma bodies

Question 7

what type of ovarian tumor, if bilateral, is a metastasis until proven otherwise?

Answer 7

mucinous

Question 8

endometrioid tumor in ovary –> mutation of _____ gene

Answer 8

PTEN

Question 9

dx: ovarian tumor, histology shows transitional type epithelium

Answer 9

Brenner tumor

Question 10

most common ovarian germ cell tumor

Answer 10

benign (mature) cystic teratomas

Question 11

dx: woman in 50s, abnormal uterine bleeding, breast tenderness, ovarian neoplasm histology shows Call-Exner bodies

Answer 11

granulosa cell tumor

Question 12

granulosa cell tumor in ovary: histology and lab finding

Answer 12

Call-Exner bodies (granulosa cells arranged haphazardly around collections of eosinophilic fluid, resembling primordial follicles)
lab finding: increased estrogen

Question 13

90% of malignant ovarian tumors are ______

Answer 13

surface epithelial-stromal cell tumors

Question 14

dx: tumor in ovaries or testes in young children, histology shows Schiller-Duval bodies (resemble glomeruli), increased AFP

Answer 14

yolk sac tumor (aggressive)