Feline infectious Peritonitis and Coronavirus Flashcards
Feline infectious peritonitis is caused by which class of virus?
Coronavirus
How does infection with FCoV occur?
In young kittens via faecal oral transmission
What is an immune complex disease?
Immune complexes are deposited in walls of small blood vessels leading to vasculitis
Antibody binding to the virus enhances the uptake by macrophages
What are the features and signs of wet FIP?
- Invariably fatal
- Accumulation of fluid within body cavities
- Depression, inappetence, weight loss, jaundice
- Fluctuating, unresponsive, fever
What are the features and signs of dry FIP?
- invariably fatal
- fluctuating unresponsive fever
- anorexia, depression , lethargy
- signs are dependant on the organ involved e.g. abdomen, CNS, eyes
What may be found in the haematology and blood biochemistry in a cat with FIP?
- Neutrophilia
- Lymphopenia
- Mild non-regenerative anaemia
- Hyperproteinaemia
- Increased liver enzymes
Describe the appearance of a fluid sample taken from an animal with FIP
- Viscous
- Straw coloured
- High protein content
- Froths if shaken
- Clots on standing
Is there a treatment for FIP?
No effective treatment
What is the term used to describe viruses needing a hosts cell to replicate?
Obligate intracellular parasite
What is the importance of a coronavirus having a lipid envelope?
Fragile, meaning they are generally short lived in the environment and are susceptible to soap and alcohol based disinfectants
Name the two feline corona virus types?
Feline infectious peritonitis virus (FIPV)
Feline enteric coronavirus (FECoV)
Whether a cat with FCoV infection develops FIP depends on what factors?
- Virus strain biotype
- Dose of virus
- Immune status of cat
What does the result of an antibody positive test mean?
It means that they were infected with FECoV, not that they have FIP
How can you prevent transmission/infection to kittens?
- Isolate queens 1-2 weeks prepartum
- early wean kittens
- isolation of kittens
Which cells are involved in replication of cell culture in:
FECoV
FIP
- Enterocytes only
- Enterocytes and macrophages
