Feline infectious disease

Question 1

Feline Panleukaemia Virus (FPV)

• CS (4)
• FIE CS (6)
• DDX (4)
• Dx (5)
• Tx (5)

Answer 1

• parvovirus
• CS : foetus 21 days: cerebellar hypoplasia, young kittens: sudden death, older kittens/cats: intestinal disease (FIE) & sever panleukopenia
• FIE CS : fever, inappetence, anorexia, vomiting, severe watery diarrhoea, secondary bacterial infections (determines severity of disease)
• DDx: intussuception, FB, acute bacterial peritonitis, poisoning
• Dx: CS, history, haematology, virus isolation (faeces/oropharyngeal swab–>PCR), serology
• Tx: nursing, IVFT, antiemetics, IV ABs, isolation

Question 2

cat flu

• viruses
• CS (7)
• Dx
• Tx (4)

Answer 2

feline calicivius
feline herpesvirus
- CS: pyrexia, depression, sneezing, conjuntivitis, severe occular and nasal discharge, dyspnoea, inappetence
-Dx: oropharyngeal swabs
-Tx: isolate, nursing, fluids, ABs

Question 3

herpes virus

• CS (2)
• persistence

Answer 3

• URT and occular signs (conjunctivits and ulcerative keratitis)
• latent in trigerminal ganglium

Question 4

Calicivirus

• virus property
• CS (4)

Answer 4

• less labile the HV

- URT, oral ulceration, viral arthritis, gingivitis/stomatitis

Question 5

chlamydophila felis

• viral property
• CS (2)
• Dx (2)
• Tx (2)

Answer 5

• unable to replicate independantly
• conjunctivitis ± mild rhinitis
• Dx: isolation, serology
• Tx: tetracyclines

Question 6

FIP

-viral properties (5)

Answer 6

• protein spikes in nucleus
• difficult to grow in lab
• mild diarrhoea 2-3 days
• virus excreted weeks before development of CS
• kittens infected by non-maternal mothers/other kittens

Question 7

Diseases of FIP (2 + 1/4)

Answer 7

• Enteric disease (FCoV): mild enteritis
• Systemic diseases (FIP): immune mediated vasculitits, complement fixation, pyogranuloma formation, vascular damage –> protein leakage

Question 8

FIP

• pathogenesis (4)
• Dx (6)
• CS of each type of FIP (3/4)

Answer 8

• ingestion –> replication in tonsils/intestinal epithelium –> replication in lymphoid tissues –> replication in other tissues
• DX: immunohistopathology of biopsy specimen, CS, history, fluid analysis, systemic inflammation, presence of virus
• Wet: effusive lesion (modified transudates): peritoneal (ascites)/ pleural (dyspnoea)
• Dry: granulomatous lesions, neurological signs (ataxia/paresis/nystagmus), liver and kidney dysfunction, occular disease (iritis/retinitis)

Question 9

FIP
-clinical pathology (4)
-serology
Tx

Answer 9

• hyperglobinaemia, lymphopenia, neutrophilia, anaemia
• FCoV serology: negative = probs not, mild - quantitative analysis, high = probs is if it also has CS
• Tx: euthanise

Question 10

Feline cowpox

Answer 10

• skin lesions on head and neck
• usually self-limiting (unless steroids/FIV +ve)
• rodent resevoir
• zoonotic