Fatty Acids + Periodontal Disease

Question 1

Periodontal disease occurs because

Answer 1

of a combination of factors
including the presence of periodontopathic bacteria and high levels of proinflammatory cytokines.

Question 2

___ fat that have shown promote inflammation in the body
Including gum

Answer 2

Saturated fats

Question 3

Key factor in the development and progression of periodontal disease

Answer 3

Chronic inflammation

Question 4

Saturated fats can activate the ___ receptors

Answer 4

Toll-like receptor

Question 5

Toll like receptor sends masj of a

Answer 5

Inflammatory pathways — increase production of pro-inflammatory cytokines and chemokines

Question 6

What is the NF-KB pathway

Answer 6

Administration of SFAs activates the nuclear
factor-kappa B which stimulates the production of
inflammatory mediators in macrophages and
gingival fibroblasts in inflamed periodontal tissue,
where they play a pathophysiologic role in
inflammatory changes

Question 7

ROS is promoted by

Answer 7

Saturated and trans fats

Question 8

Highly reactive molecules that contain oxygen and
can cause oxidative stress

Answer 8

ROS

Question 9

Reactive oxygen species

Answer 9

ROS

Question 10

Oxidative stress happen when

Answer 10

when there is an imbalance between the production of ROS and the body’s antioxidant defense mechanisms

Question 11

Oxidative stress can impair body’s …

Answer 11

Ability to repair and regenerate periodontal tissues

Question 12

Why is a compromised immune response allows bacteria to proliferate

Answer 12

Oxidative stress impairment immune function, making it susceptible to perio enf

Question 13

SFAs enhance … by preventing apoptosis

Answer 13

Osteoclast survival

Question 14

Excess osteoclastic act leads to …

Answer 14

an imbalance in bone
remodeling which favors resorption associated with
periodontal disease.

Question 15

Omega 3 and omega 6 have important

Answer 15

inflammatory modulators and potential protective effects

against periodontal disease due to their anti-inflammatory
properties and their role in modulating the immune
response

Question 16

Omega __ promote perio health

Answer 16

3

Question 17

The most important polyunsaturated fats are
for regulation of inflammation

Answer 17

n-3 derivatives docosahexaenoic acid (DHA),
eicosapentaenoic acid (EPA), and docosapentaenoic
acid (DPA) and n-6 derivative arachidonic acid (AA).

Question 18

The oxidation of DHA, EPA, DPA, AA by ____ produces prostaglandins, leukotrienes, lipoxins, resolvins, and protectins.They act as intercellular signaling molecules and can have either pro- or anti-inflammatory effects

Answer 18

cyclooxygenase and lipoxygenase

Question 19

Omega 3 is found in

Answer 19

Fatty fish
Salmon, mackerel, and sardines

Question 20

Omega 3 support the synthesis of an anti.inflammatory lipid mediator,
That help healing process

Answer 20

Resolvins
And
Protectins

Question 21

Arachi ac AA
Is involved in ____ of the inflammatory response

Answer 21

modulating the intensity and duration of inflammatory responses

Question 22

Arachi ac AA
Is involved in ____ bone during periodontitis

Answer 22

the process that results in bone loss during periodontitis

Question 23

main proinflammatory products of AA metabolism

Answer 23

prostaglandins and leukotrienes