Fat Metabolism Flashcards
what conditions can fatty acid be used in only?
aerobic conditions as there is breakdown in the mitochondria
What happens in B-oxidation pathway?
TAG hydrolysed to FFA, 2 carbons removed as acetyl coa , NADH and FADH2 produced, enters krebs and energy produced as ATP , needs o2 for oxidative phosphorylation
where does FA breakdown occur?
in mitochondrial matrix, activated in cytoplasm before and produced fatty acyl coA uses ATP to make acyl coA synthetase
what do long chain acyl coAs need as a carrier?
carnitine - enzyme cat-1 outside mitochondria and cat-2 inside
What is cat 1 inhibited by?
malonyl coA slows Carbs for energy
Insulin for high blood glucose
Can animals convert FA direct to glucose?
no
where does oxidation occur?
in electron transport chain
how many ATP in b-oxidation?
106
if carbs are lacking what does acetyl coA make?
ketone bodies - acetoacetic acid, b-hydroxybutyric acid and acetone
where can ketone bodies accumulate?
in diabetes, trauma and starvation as actoacetate oroduced faster
Where is ketone bodies mainly used?
heart and kidney cortex
what ketone bodies are strongly acidic and disturb acid-base?
b-hydroxybutyric acid
what happens in diabetics with ketoacidosis?
prevents glucose absorption results in hyperglycemia and dehydration
what is MCAD defiency?
autosomal recessive -
nonsynonymous mutation, medium chain acyl coz dehydrogenase defiency blocks oxidation of fatty acyl co a cant make acetyl coa
