F33 Flashcards

1
Q

Hvilken aminosyre er specielt sårbar over for ændringer i pH?

A

Histidin.

pKs: 6,4

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2
Q

Hvordan transporteres CO2?

A

10% frit opløst
60% HCO3-
30% carbamino

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3
Q

Hvordan udskilles det meste H+ i urinen?

A

H+ er bundet til buffere som NH4+ og H2PO4-

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4
Q

Hvordan håndterer kroppen syrer og baser?

A
Buffering:
-Bufferkapacitet 
Udskillelse:
-Respiration
Transport over cellemembran
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5
Q

Hvordan fungerer en buffer?

A

Et molekyle med pKs tæt på pH. En ændring i pH vil derfor bliver “absorberet” af bufferen.

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6
Q

Hvorfor opstår der acidose ved iskæmi?

A

Fordi vi ikke længere kan komme af med CO2. Systemet er derfor lukket.

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7
Q

Hvor reabsorberes det meste bikarbonat i nyren?

A

80% i proximal tubulus

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8
Q

Beskriv kanaler og transportere i proximal tubulus for bikarbonat

A

Apikalt:

  • Na+/H+-exchanger(Natriums gradient)
  • H+-ATPase

Basalt:

  • Na+/K+-ATPase
  • Na+/3HCO3- symporter(bikarbonats gradient)
  • Cl-/HCO3- exchanger
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9
Q

Beskriv kanaler og transportere i TAL for bikarbonat

A

Apikalt:

  • Na+/H+-exchanger(Natriums gradient)
  • H+-ATPase

Basalt:

  • Na+/K+-ATPase
  • Cl-/HCO3- exchanger
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10
Q

Beskriv kanaler og transportere i samlerør for bikarbonat

A

Apikalt:

  • H+/K+-ATPase
  • H+-ATPase

Basalt:

  • HCO3-
  • Cl-
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11
Q

Hvordan produceres der bikarbonat?

A

Phosphorsyre

Alpha-ketaglutarat

Ammonium

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