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Pharmacology FINAL (2nd sem) > EXTRA > Flashcards

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1
Q

SE Linezolid

A

Inhibit MAO-A/B so Serotonine syndromein combination with SSRI’s
Thrombocytopenia

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2
Q

Metronidazole SE

A

Disulfiram like reaction with alcohol
Metalic taste

רכבת זה דבר שמרגישים בו מסוחררים פלוס זה פשוט גוש של מתכת

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3
Q

Mertonidazole MOA

A

Makes free radicals which interfears with nucleic acid production

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4
Q

Fidaxomycin MOA

A

Inhibits RNA pol
C. difficile
Fidaxo for diFFFFicile

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5
Q

Rifaximin

A

Derivative of Rifampicin
RNA pol
For IBS
For hepatic encephalopathy

זה פשוט יושב במעיים אז כמעט ללא תופעות לוואי

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6
Q

Metronidazole in case of H.Pylori

A

PPI
Amoxicillin / Metro
Clarythromycin

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7
Q

Nitrofurantoin- Everything

A

נכנס מהר לשתן אז אין לו אפקט סיסטמתי
לא לפרוטאוס ולא לפסאודומונאס!! הם חמורים יותר
urine acidity enhance activity

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8
Q

Fosfomycin- Everything

A

Inhibits synthesis of NAG- cell wall (enolpyruvate transferase)
For uncomplicated UTI
GI SE

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9
Q

Direct Thrombin inhibitors

A

Dabigatran

Bivalirudin

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10
Q

Reversible agent fot Heparin

A

Protamine

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11
Q

Management of acute bleeding in patients with Hemophilia

A

Aminocaproic acid

Inhibits plasminogen activation

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12
Q

Myeloid growth factor

A

Filgrastim stimulate G-CSF

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13
Q

Dopamine D2-R agonist

A

Bromocriptine

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14
Q

Busipron indication

A

5HT1A partial agonist

General anxiety

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15
Q

Management of status epalipticus

A

Lorazepam/Midazolam

Phenytoin/Leveteracetam

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16
Q

RA pharmacology

A

Acute: NSAID’s

Disease Modifying: Methotrexate

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17
Q

IBD pharmacology

A

Mild: 5-ASA
Moderate: Glucoroticosteroids, 6-MP

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18
Q

Immunotherapy- Fusion and Ab and MOA

A

Rituximab- anti CD20. reduce B. Ritux reduce B
Infliximab, Adalimumab- Anti TNFa
Toclizumab- Anti IL6. T+B
Ustekinumab- Anti IL12. inhib TH1
Natalizumab- Inhibit T cell anti integrin נטטטלי
Dupilumab- Anti IL4 די זה האות הרביעית
Abatacept- Fusion protein inhib. CD28 on T cell. אבא תצא! הפיוזון הזה לא טוב לך. אבטצפת הכי לא קשור

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19
Q

Infliximab, Adalimumab- MOA

A

Anti TNFa

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20
Q

Inhib. of Cytokine gene expression indications

A

Mostly before bone marrow transp.

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21
Q

Opioids- analgesia

A

Hydromorphone- strong. analgesia
Fentanyl- strong. analgeisa and anesthetica
Tramadol- weak. analgesia. also inhibits 5HT reuptake
Merphidine- strong. analgesia
Oxycodone- analgesic

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22
Q

Opioids- שלשול

A

Loperamide, Diphenoxylate

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23
Q

התמכרות וחוט שדרה Addiction and spinal cord

A

Methadone, Buprenorphine

Nalbuphine

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24
Q

Dont give Valproate with

A

Thiazides and NSAID’s

They decrese the clearance

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25
Q

Anti epileptic which are not broad spectrum

A

Phenytoin- Inhib. of axonal NaCh
Carbamazapine- -“-
Vigabatrin- Inhibits GABA metab.
Phenobarbital- GABA NaCh open longer

Very Privet Cards Play
Privet bcs it is narrow spectrum

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26
Q

Give Cidofovir with

A

Probenecid

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27
Q

5th gene cephalo

A

Ceftolozane+tazobactam

Ceftarolin-fosamil

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28
Q

Acetazolamide indications

A 
Diuretic only if also metabolic alkalosis
Glaucoma
Mountain sickness
Epilepsy
Meiners disease
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29
Q

Thiazide diuretics

A

Hydrochlorothiazide

Indapamide

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30
Q

Thiazides MOA

A

Na/Cl inhib

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31
Q

Thiazides SE

A 
Hyper GLUC
Glycemic
Lipidemic
Uricemic
Calcemic
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32
Q

ADH antag.

A

Tolvaptan

For SIADH

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33
Q

CCB and other vasodilators

A 
Amlodipine, Nifedipine, Nimodipine, Felodipine
Hydralazine release NO
Bosenta inhibits Endothelin
Sildenafil inhibits PDE5
Verapamil
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34
Q

Maximum daily dose Paracetamol

A

4X1,000 mg

35
Q

Which ulcer grug has constipation SE?

A

Sucralfate

36
Q

Dopamine D2-R agonist

A

Bromocriptine

For the inhibition of Prolactine`

37
Q

Reversal of Heparin

38
Q

Direct acting Thrombin inhib.

A

Dagibatran

Bivalirudin

39
Q

NOAC

A

Rivaroxaban

Dagibatran

40
Q

Reverse activity of Alteplase/Reteplase

A

Aminocaproic acid

41
Q

Stimulator of G-CSF

A

Filgrastim

42
Q

B12 preperation- synthetic

A

Hydroxy cobalamine

43
Q

ATC

A

Anatomic
Theraputic
Classification

44
Q

Pharmacovigilance terms

A

Adverse drug event
Adverse event
Serious adverse effect

45
Q

IV anasthetics that stimulates the heart

46
Q

IV anasthetics with minimal changes to the heart

47
Q

5-HT 1A partial agonist

Inhibitory receptor

A

Busipron

לתת בוסה למי שעוזר לך עם אנקזייטי

48
Q

Dopamine amount in schizofrenia

A

Mesolimbic- increased

Mesocortical- decreased

49
Q

Drug that is very likely to cause NMS

A

Haloperidol

50
Q

Typical antipsychotics

A

Chlorpromazine
Haloperidol
Flupentixol
Droperidol

CHF-D

Hallo! So tipical of you to promise no chlor. Drop now and flow from here

51
Q

Atypical antipsychotics

A 
Atypical cloz-ap
-pine suffix
Clozapine
Olanzapine
Quetiapine

Risperidone- ris and peri are done!
Aripiprazole- ari piped to raz
Tiapride- alcohol psychosis. Tia to pride to drink alcohol
Cariprazine- Caring the prize for the hungarian developer

52
Q

Cidofovir and Foscarnet

A

Ibhibit viral DNA pol

FOScarnet is a pyroFOSfate analog

53
Q

Give ____ with Cidofovir

A

Probenecid

Do me a favor

54
Q

Atypical antipsych R blocking

55
Q

Clozapine SE

A 
No TD
Agranulocytosis
Seizures
Myocarditis
Metabolic things
56
Q

Long acting Atypical antipsych

A

Aripiprazole

Partial agonist

57
Q

Trazadone MOA

A

Inhibitor of 5-HT 2A

58
Q

Bupropion

A

Inhibition on dopamine reuptake

59
Q

Maprotiline MOA

A

NET&raquo_space; SERT

60
Q

SNRI given in Diabetic neuropathy

A

Duloxetine

61
Q

Dopamine agonist fot the Tx. of Parkinsons

A

Ropinerole

Pramipexol

62
Q

NMDA blocker for Alzheimer

63
Q

Anti emetic Serotonine blockers

A

Ondansetron
Palonosetron

Serotonin makes you dance
You eat 3 meals a day
5-HT-3

64
Q

Laxatives

A 
Sennoside, Bisacodyl
Fibers
Mg-Sulfate
Lactulose
Paraffin
65
Q

Anti-diarrhea

A

DAL!
Diphenoxylate- opioid
Active charcoal
Loperamide- opioid

66
Q

Liver drugs

A

Silymarine

N acetyl cyteine

67
Q

Mebendazole MOA

A

Inhibit microtubule

68
Q

-Azoles

A

Clotriconazole
Itraconazole
Voriconazole
Fluconazole

69
Q

CMV drug co administrated with Probenecid

A

Cidofovir

Do me a favor

70
Q

NRTI’s

A 
Abacavir
Ziduvodine
Tenofovir
Lamivudine
Emtricitabine
71
Q

Which NRTI causes Fanconi’s syndrome?

72
Q

NNRT

A

Etravirine

אתרע מזלו לא להיות אנארטיאיי

73
Q

Protease inhibitors

A

Ritonavir
Darunavir
Lopinavir

Rita inhibited Rami

74
Q

Which drug boost CYP 450

AIDS drug

75
Q

Integrase inhibitor

A

Elvitegravir

Elvis is in the grave

InteGRase-Gravir

76
Q

AIDS Tx. regimen

A

Emticitabine+Tenofovir+other class

2+1

77
Q

1st gene cefalosporin indications

A

Surgical prophylaxis

78
Q

B lactamase inhib.

A

Tazobactem

Vaborbactem

79
Q

Aztreonam MOA

A

Bind PBP3 on G-

80
Q

Imipenem is given with

A

Cilastatin

81
Q

Centrally acting m relaxant

A

Baclofen GABA-B
Diazepam
Tizanidine a2 agon.
Tolperisoneinhib muscle stretch R

TITO is my BADI

82
Q

Short acting muscle relaxant

A

Mivacurium

מי הוא חושב שהוא שהוא בא ככה והולך כל כך מהר

83
Q

Anti -asthma

A 
Prednisolone
Methyl
Budesonide
Monteleukast
Omalizumab- IgE
84
Q

Anti- tussive

A

Codeine
Butamirate

Acetylcysteine
Bromhexine

Pharmacology FINAL (2nd sem) (37 decks)

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