EXTRA Flashcards by M AAB

SE Linezolid

Inhibit MAO-A/B so Serotonine syndromein combination with SSRI’s
Thrombocytopenia

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Metronidazole SE

Disulfiram like reaction with alcohol
Metalic taste

רכבת זה דבר שמרגישים בו מסוחררים פלוס זה פשוט גוש של מתכת

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Mertonidazole MOA

Makes free radicals which interfears with nucleic acid production

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Fidaxomycin MOA

Inhibits RNA pol
C. difficile
Fidaxo for diFFFFicile

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Rifaximin

Derivative of Rifampicin
RNA pol
For IBS
For hepatic encephalopathy

זה פשוט יושב במעיים אז כמעט ללא תופעות לוואי

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Metronidazole in case of H.Pylori

PPI
Amoxicillin / Metro
Clarythromycin

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Nitrofurantoin- Everything

נכנס מהר לשתן אז אין לו אפקט סיסטמתי
לא לפרוטאוס ולא לפסאודומונאס!! הם חמורים יותר
urine acidity enhance activity

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Fosfomycin- Everything

Inhibits synthesis of NAG- cell wall (enolpyruvate transferase)
For uncomplicated UTI
GI SE

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Direct Thrombin inhibitors

Dabigatran

Bivalirudin

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Reversible agent fot Heparin

Protamine

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Management of acute bleeding in patients with Hemophilia

Aminocaproic acid

Inhibits plasminogen activation

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Myeloid growth factor

Filgrastim stimulate G-CSF

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Dopamine D2-R agonist

Bromocriptine

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Busipron indication

5HT1A partial agonist

General anxiety

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Management of status epalipticus

Lorazepam/Midazolam

Phenytoin/Leveteracetam

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RA pharmacology

Acute: NSAID’s

Disease Modifying: Methotrexate

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IBD pharmacology

Mild: 5-ASA
Moderate: Glucoroticosteroids, 6-MP

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Immunotherapy- Fusion and Ab and MOA

Rituximab- anti CD20. reduce B. Ritux reduce B
Infliximab, Adalimumab- Anti TNFa
Toclizumab- Anti IL6. T+B
Ustekinumab- Anti IL12. inhib TH1
Natalizumab- Inhibit T cell anti integrin נטטטלי
Dupilumab- Anti IL4 די זה האות הרביעית
Abatacept- Fusion protein inhib. CD28 on T cell. אבא תצא! הפיוזון הזה לא טוב לך. אבטצפת הכי לא קשור

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Infliximab, Adalimumab- MOA

Anti TNFa

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Inhib. of Cytokine gene expression indications

Mostly before bone marrow transp.

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Opioids- analgesia

Hydromorphone- strong. analgesia
Fentanyl- strong. analgeisa and anesthetica
Tramadol- weak. analgesia. also inhibits 5HT reuptake
Merphidine- strong. analgesia
Oxycodone- analgesic

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Opioids- שלשול

Loperamide, Diphenoxylate

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התמכרות וחוט שדרה Addiction and spinal cord

Methadone, Buprenorphine

Nalbuphine

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Dont give Valproate with

Thiazides and NSAID’s

They decrese the clearance

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Anti epileptic which are not broad spectrum

Phenytoin- Inhib. of axonal NaCh Carbamazapine- -"- Vigabatrin- Inhibits GABA metab. Phenobarbital- GABA NaCh open longer Very Privet Cards Play Privet bcs it is narrow spectrum

Give Cidofovir with

Probenecid

5th gene cephalo

Ceftolozane+tazobactam | Ceftarolin-fosamil

Acetazolamide indications

``` Diuretic only if also metabolic alkalosis Glaucoma Mountain sickness Epilepsy Meiners disease ```

Thiazide diuretics

Hydrochlorothiazide | Indapamide

Thiazides MOA

Na/Cl inhib

Thiazides SE

``` Hyper GLUC Glycemic Lipidemic Uricemic Calcemic ```

ADH antag.

Tolvaptan | For SIADH

CCB and other vasodilators

``` Amlodipine, Nifedipine, Nimodipine, Felodipine Hydralazine release NO Bosenta inhibits Endothelin Sildenafil inhibits PDE5 Verapamil ```

Maximum daily dose Paracetamol

4X1,000 mg

Which ulcer grug has constipation SE?

Sucralfate

Dopamine D2-R agonist

Bromocriptine | For the inhibition of Prolactine`

Reversal of Heparin

Protamine

Direct acting Thrombin inhib.

Dagibatran | Bivalirudin

NOAC

Rivaroxaban | Dagibatran

Reverse activity of Alteplase/Reteplase

Aminocaproic acid

Stimulator of G-CSF

Filgrastim

B12 preperation- synthetic

Hydroxy cobalamine

ATC

Anatomic Theraputic Classification

Pharmacovigilance terms

Adverse drug event Adverse event Serious adverse effect

IV anasthetics that stimulates the heart

Ketamine

IV anasthetics with minimal changes to the heart

Etomidate

5-HT 1A partial agonist | Inhibitory receptor

Busipron לתת בוסה למי שעוזר לך עם אנקזייטי

Dopamine amount in schizofrenia

Mesolimbic- increased | Mesocortical- decreased

Drug that is very likely to cause NMS

Haloperidol

Typical antipsychotics

Chlorpromazine Haloperidol Flupentixol Droperidol CHF-D Hallo! So tipical of you to promise no chlor. Drop now and flow from here

Atypical antipsychotics

``` Atypical cloz-ap -pine suffix Clozapine Olanzapine Quetiapine ``` Risperidone- ris and peri are done! Aripiprazole- ari piped to raz Tiapride- alcohol psychosis. Tia to pride to drink alcohol Cariprazine- Caring the prize for the hungarian developer

Cidofovir and Foscarnet

Ibhibit viral DNA pol | FOScarnet is a pyroFOSfate analog

Give ____ with Cidofovir

Probenecid | Do me a favor

Atypical antipsych R blocking

5-HT 2A

Clozapine SE

``` No TD Agranulocytosis Seizures Myocarditis Metabolic things ```

Long acting Atypical antipsych

Aripiprazole | Partial agonist

Trazadone MOA

Inhibitor of 5-HT 2A

Bupropion

Inhibition on dopamine reuptake

Maprotiline MOA

NET >> SERT

SNRI given in Diabetic neuropathy

Duloxetine

Dopamine agonist fot the Tx. of Parkinsons

Ropinerole | Pramipexol

NMDA blocker for Alzheimer

Memantine

Anti emetic Serotonine blockers

Ondansetron Palonosetron Serotonin makes you dance You eat 3 meals a day 5-HT-3

Laxatives

``` Sennoside, Bisacodyl Fibers Mg-Sulfate Lactulose Paraffin ```

Anti-diarrhea

DAL! Diphenoxylate- opioid Active charcoal Loperamide- opioid

Liver drugs

Silymarine | N acetyl cyteine

Mebendazole MOA

Inhibit microtubule

-Azoles

Clotriconazole Itraconazole Voriconazole Fluconazole

CMV drug co administrated with Probenecid

Cidofovir | Do me a favor

NRTI's

``` Abacavir Ziduvodine Tenofovir Lamivudine Emtricitabine ```

Which NRTI causes Fanconi's syndrome?

Tenofovir

NNRT

Etravirine | אתרע מזלו לא להיות אנארטיאיי

Protease inhibitors

Ritonavir Darunavir Lopinavir Rita inhibited Rami

Which drug boost CYP 450 | AIDS drug

Ritonavir

Integrase inhibitor

Elvitegravir Elvis is in the grave InteGRase-Gravir

AIDS Tx. regimen

Emticitabine+Tenofovir+other class 2+1

1st gene cefalosporin indications

Surgical prophylaxis

B lactamase inhib.

Tazobactem | Vaborbactem

Aztreonam MOA

Bind PBP3 on G-

Imipenem is given with

Cilastatin

Centrally acting m relaxant

Baclofen GABA-B Diazepam Tizanidine a2 agon. Tolperisoneinhib muscle stretch R TITO is my BADI

Short acting muscle relaxant

Mivacurium מי הוא חושב שהוא שהוא בא ככה והולך כל כך מהר

Anti -asthma

``` Prednisolone Methyl Budesonide Monteleukast Omalizumab- IgE ```

Anti- tussive

Codeine Butamirate Acetylcysteine Bromhexine