A: 5-11 Flashcards
Local anasthetics classifications
Amides: Lidocaine, Articaine, Bupivacaine
לידוקאין זה ברור. ללקק ארטיק עם הבובי שלך כמו לוקל
Ester: Cocaine
All metab. by CYP450
Drug with the fastest onset of action local anasth.
Articaine
אתה אוכל ארטיק וישר זה מקפיא לך את המח
Long acting local anasth.
Bupivacaine
CNS toxicity!
Cocaine metabolism
By Pseudocholinestrase
Excesp cocaine, all local anasthetics are
Vasodilators
Glucocorticoids for parenteral and oral use
Hydrocortisone- short. Replacement of cortisol
Prednisolone- Systemic anti inflammatory
Methylprednisolone- Systemic anti inflammatory
Dexamethasone- Diagnosis ACTH. Asthma
Triamcinolone- Topical
Mineralocorticoids
Fludrocortisone
Flud like fluid
Metyrapone- Blocks Cortisol synthesis. Diagnosis of Adrenal insuf.
מתיר לנו לבדוק
Topical glucocorticosteroids
Fluocinolone
Budesonide
Momethasone
Fluticasone
Best Friends For Me
Androgens
Testosterone undecanoate (Causes Virilization in female) Nandrolone is anabolic steroid
Anti androgens
Bicalutamide for prostate cancer
5a reductase inhibitor
Finasteride for male baldness
BPH
Like thin- thinning hair
finA- a reductase
GnRH drugs
Goserelin- GO GO GO! agonist! Prostate cancer
Degarelix- antagonist. For prostate cancer
Sildenafil indications
PDE5 inhib!
BPH
Pulmonary HTN
Erectile
Estrogens
Ethinylestradiol
Anti estrogens
Tamoxifen- breast cancer
Raloxifen- osteoporosis
Clomifen- ovulation induction.
Tmai Relax! אין לך כלום
Antagonist on breast CNS uterus
Agonist on bone and liver
Aromatase inhibitor
Anastrozol
אנס את הארומטייז
Anti PLT
Aspirin- Reduce TXA2 production
Clopidogre, Ticagrelor, Prasogrel- ADP-R antag.
Abciximab- IgG against GPIIb/IIIa
Dual anti PLT
Aspirin + Clopidogrel
ADP-R antag.
Clopidogrel and Prasogrel are pro drug. activated by CYP450
Ticagrelor is already active
למי שיש טיקה על המצח הצ’אקרות שלה כבר פתוחות
Contraceptive- MOA
Ethynyl-estradiol/Levonogestrel-
Levonogestrel
Medroxy-progesteron-acetate
Desogestrel
Prevent LH surge
Combination agents are divided into
Monophasic- same dose of both components
Biphasic- changes twice a cycle
Triphasic- “ three times “
Morning after pill
High dose Progesteron
Levonogestrel
Medroxy-progesteron-acetate
long-acting progestogen-only injectable contraceptive
treat and prevent menopausal symptoms
3 months duration for the injection
Elevated EC Ca and local anasthetics
Partially antagonizes
Elevated EC K+ and local anasthetics
Enhanced effect of local anasthetics
How do local anasthetics block VGNaCh?
Non ionized form crosses the memb
Ionized form blocks the channel from within
