B: 20,21

Question 1

Drugs for the Tx. of angina

Answer 1

CCB
BB
Nitroglycerine
Isosorbide mononitrate

Question 2

Pharmacotherapy of ischaemic heart disease

Answer 2

1. Trimetazidine- Trimetazidine inhibits beta-oxidation of fatty acids by blocking long-chain 3-ketoacyl-CoA thiolase, which enhances glucose oxidation.[8] In an ischaemic cell, energy obtained during glucose oxidation requires less oxygen consumption than in the beta-oxidation process.
2. Ivabradine- inhibits I-funny ch in SA node which leads to hyperpolarization and decreased HR

Question 3

Which CCB in case of angina?

Answer 3

Nifedipine
Verapamile
Diltiazem

Question 4

Nitrates MOA

Answer 4

Release NO
cGMP increases
Myosine light chain dephosph.
Smooth muscle relaxation

Venous»»>arteries
Reduce preload

Question 5

Agents used in dyslipidemia

Answer 5

Simvastatin- שים אותו כדי שיעשו לו אקטיביישן
Atorvastatin
Bosuvastatin- Bosu boll is round like obese people
Ezetimib
Fenofibrate
Colesevelam

Question 6

Statins

Answer 6

HMG-CoA reductase inhib.
Increased LDL-R expression
Reduce 30-50% plasma LDL
Reduced TRG

SE: hepatotoxicity, Myalgia, Rhabdo.
Dont give in pregnancy

Question 7

Ezetimib

Answer 7

Block NPC1L1 sterol transporter in intestine brush border

Question 8

Colesevelam

Answer 8

Large polymer
Bind bile acids and prevent absorption
So cholesterol in body converted to bile
Give in prirmary hypercholesterolemia

Question 9

Fenofibrate

Answer 9

PPAR-a agonist
Up regulate LPL
Icrease TRG clearance