Exocrine Pancreas

Question 1

Is amylase specific for pancreatic injury?

Answer 1

Nope

Also not particularly sensitive - can have normal amylase with pancreatitis

Question 2

An amylase > 3-4x upper end of normal suggests??

Answer 2

Pancreatic injury

Question 3

Is lipase specific for pancreatic injury?

Answer 3

Nope also not very sensitive

Question 4

A lipase > 2x upper end of normal suggests?

Answer 4

Pancreatic injury

Question 5

In dogs, if you have a normal amylase and a increased lipase, what should you consider?

Answer 5

Corticosteroids

Dexamethasone - up to 5x the normal limit

Question 6

T/F: dogs with renal failure can have an increased amylase or lipase

Answer 6

True

Question 7

If peritoneal levels of amylase/lipase are greater than serum, this suggests

Answer 7

Pancreatitis

Can also be increased with intestinal perforation

Question 8

T/F: trypsinogen is pancreas-specific

Answer 8

True

Question 9

Will dexamethasone increase trypsin-like immunoreactivity (TLI) ?

Answer 9

Yes

Question 10

If you have a TLI > 50ug/L in a dog it suggests?

Answer 10

Pancreatitis

Question 11

A TLI > 100ug/L suggests pancreatitis in what species?

Answer 11

Cat

Question 12

Is PLI or TLI better for diagnosis of exocrine pancreatic insufficiency?

Answer 12

TLI

Question 13

Can pancreatic lipase immunoreactivity be increased with drugs?

Answer 13

Yes

Anticonvulsant drugs

Question 14

In cats, a PLI greater than ____mg/L is consistent with pancreatic inflammatory disease. In dogs _______mg/L is consistent with pancreatic inflammatory disease

Answer 14

12; 400

Question 15

What is a good prognostic test for acute pancreatitis and accurately predicts the amount of necrosis

Answer 15

C-reactive protein

Question 16

With pancreatitis, can you see increases Or decreases in glucose, calcium, and liver enzymes?

Answer 16

Hyperglycemia -stress, excitement, glucagon

Hypocalcemia - saponified fat

Increased liver enzymes

Question 17

What can cause increases in amylase in horses?

Answer 17

Pancreatitis

Intestinal disease

• proximal enteritis
• colic

Question 18

Amylase is decreased in a cat, what does this tell you?

Answer 18

Nothing.. useless..

Question 19

What is the best test to determine pancreatitis in cats?

Answer 19

PLI

Peritoneal fluid amylase/lipase may help

Question 20

Pancreatitis predisposes patients to??

Answer 20

Hepatic lipidosis, obstructive jaundice, pulmonary thrombosis, and exocrine pancreatic insufficiency

Question 21

What is the most common predisposing factor to pancreatitis in cats?

Answer 21

Inflammatory bowel disease