Exocrine Pancreas Flashcards
Is amylase specific for pancreatic injury?
Nope
Also not particularly sensitive - can have normal amylase with pancreatitis
An amylase > 3-4x upper end of normal suggests??
Pancreatic injury
Is lipase specific for pancreatic injury?
Nope also not very sensitive
A lipase > 2x upper end of normal suggests?
Pancreatic injury
In dogs, if you have a normal amylase and a increased lipase, what should you consider?
Corticosteroids
Dexamethasone - up to 5x the normal limit
T/F: dogs with renal failure can have an increased amylase or lipase
True
If peritoneal levels of amylase/lipase are greater than serum, this suggests
Pancreatitis
Can also be increased with intestinal perforation
T/F: trypsinogen is pancreas-specific
True
Will dexamethasone increase trypsin-like immunoreactivity (TLI) ?
Yes
If you have a TLI > 50ug/L in a dog it suggests?
Pancreatitis
A TLI > 100ug/L suggests pancreatitis in what species?
Cat
Is PLI or TLI better for diagnosis of exocrine pancreatic insufficiency?
TLI
Can pancreatic lipase immunoreactivity be increased with drugs?
Yes
Anticonvulsant drugs
In cats, a PLI greater than ____mg/L is consistent with pancreatic inflammatory disease. In dogs _______mg/L is consistent with pancreatic inflammatory disease
12; 400
What is a good prognostic test for acute pancreatitis and accurately predicts the amount of necrosis
C-reactive protein
With pancreatitis, can you see increases Or decreases in glucose, calcium, and liver enzymes?
Hyperglycemia -stress, excitement, glucagon
Hypocalcemia - saponified fat
Increased liver enzymes
What can cause increases in amylase in horses?
Pancreatitis
Intestinal disease
- proximal enteritis
- colic
Amylase is decreased in a cat, what does this tell you?
Nothing.. useless..
What is the best test to determine pancreatitis in cats?
PLI
Peritoneal fluid amylase/lipase may help
Pancreatitis predisposes patients to??
Hepatic lipidosis, obstructive jaundice, pulmonary thrombosis, and exocrine pancreatic insufficiency
What is the most common predisposing factor to pancreatitis in cats?
Inflammatory bowel disease
