Excretory Sytem Flashcards
What are the substances that animals accumulate ?
Ammonia Urea Uric acid CO2 Water Ions ( Na+ , K+, Cl- , phosphate , sulphate )
Animals accumulate substances like ammonia ,urea ,uric acid CO2 ,H2O and ions either by ___or by other means like _____.
Metabolic activities
Excess ingestion
Accumulated substances have to be removed _or ____.
Totally
Partially
Name some ions which are accumulated in our bodies and have to be removed -
Na+ K+ Cl- Phosphate Sulphate
Major forms of nitrogenous wastes excreted by animals -
3
Ammonia
Urea
Uric acid
_____is the most TOXIC form of N2 waste excreted by animals .
Ammonia
Ammonia requires _____ for its elimination .
Large amount of water ( becoz it us highly toxic )
_is the least toxic form of N2 waste .
Uric acid
____can be removed with a minimum loss of water . Why ?
Uric acid
Least toxic in nature
He process of excreting ammonia is called -
ammonotelism
Name some ammonotelic organisms -
3 Bony fishes Aquatic amphibians Aquatic insects (All aquatic ones )
__, as it is readily soluble , is generally excreted by diffusion across body surfaces or through gill surfaces ( in fish ) as ____ .
Ammonia
Ammonium ions
How is ammonia excreted by aquatic amphibians , bony fishes and aquatic insects?
It is excreted by diffusion across the body surface or through gills surface as in fishes as ammonium ions because it is readily soluble.
____necessitated the production of lesser toxic nitrogenous waste like ___and ____ for_____.
Terrestrial adaptations
Urea
Uric acid
Conservation of water
Name some UREOTELIC organism -
Excrete urea - 3
Mammals
Many terrestrial amphibians
Marine fishes
__produced by metabolism is converted into ___ in the ___ of UREOTELIC animals and released into the blood which is filtered and excreted out by kidneys .
Ammonia
Urea
Liver
Some amount of urea may be retained in. The __of UREOTELIC animals .
Kidney matrix
Why some amount of urea retained in the kidney matrix of UREOTELIC animals ?
To maintain a desired OSMOLARITY
How is UREA excreted by UREOTELIC animals ?
1) ammonia is produced by metabolism
2) ammonia is converted into UREA in the liver
3) liver releases this urea into the blood
4) urea is filtered from the blood and excreted out by the KIDNEYS .
_is produced by metabolism in UREOTELIC organisms.
Ammonia
Name some organisms which excrete N2 wastes as URIC acid -
Uricotelic -4 Reptiles Birds Land snails Insects
Uricotelic organisms excrete uric acid in the form of _or ___ with a _____ of water .
Pellets
Paste
Minimum loss
In most of the invertebrates , excretory structures are _forms whereas vertebrates have ____.
Simple tubular forms
Complex tubular organs -kidneys
_are the excretory structures in Platyhelminthes ( flatworms).
PROTONEPHRIDIA / flame cells
Flame cells are the excretory structures of -
Flatworms . (Ex planarian )
Rotifers
Some annelids
Cephalochordata (ex-amphioxus)
PROTONEPHRIDIA /flame cells are primarily concerned with ___and ___regulation . This is called -
Ionic
Fluid volume
Osmoregulation
Amphioxus has __As its excretory structure .
PROTONEPHRIDIA / flame cells
__are the TUBULAR excretory structures of earthworms .
Nephridia
Annelids have _as their excretory structures .
Mainly - NEPHRIDIA
Some annelids - PROTONEPHRIDIA
Nephridia help to maintain a fluid and ionic balance . T/F
T
Malphigian tubules are the excretory structures of most of the ____.
Insects - including cockroaches
__or ___ perform the excretory function in CRUSTACEANS like PRAWNS 🦐.
Antennal glands
Green glands
In humans , the excretory system consists of what components ?
A pair of kidneys
One pair of ureters
A urinary bladder
A urethra
Kidneys are reddish -brown , bean shaped structures situated BTW the levels of __and ___ VERTEBRA .
Last thoracic
3rd lumbar
Exact location of kidneys -
Situated btw the levels of last thoracic and 3rd lumbar vertebra close to the dorsal inner wall of the abdominal cavity .
Each kidney in an adult human measures ___in length .
10-12 cm
Each kidney in an adult human measures ___in width .
5-7cm
Each kidney in an adult human measures ___in thickness
2-3 cm
Average weight of kidneys -
120-170 g
Towards the centre of the inner CONCAVE surface of the kidney is a ___.
Notch - called hilum
Through the HILUM , __,___and ____enter .
Ureter
Blood vessels
Nerves
Inner to the ___ is a brood funnel shaped space called RENAL PELVIS .
Hilum
____has PROJECTIONS called CALYCES
Renal pelvis
Renal pelvis is ___in shape and and is situated ____ and contains ____.
Funnel -shaped
Inner to the hilum
Projections -calyces
The OUTER LAYER of the kidney is a ___.
Tough capsule
Inside th kidney , there are _zones .name -
2
Outer- cortex
Inner- medulla
The medulla (inner zone of kidneys ) is divided into __
A few conical masses - MEDULLARY PYRAMIDS
Medullary pyramids are _in shape and they project into the ___.
Conical
Calyces ( projections of renal pelvises inner to hilum )
The cortex(outer part of kidney ) extends in btw ______.
Medullary pyramids
The cortex of the kidneys extends btw the MEDULLARY PYRAMIDS as ____ , called ____.
Renal columns
Columns of bertini
What are columns of BERTINI ?
The part of cortex extending btw the medullary pyramids as RENAL COLUMNS are called the columns of bertini
Each kidney has approx ______ complex tubular structures called NEPHRONS .
1 million
Nephrons are the ____units .
Functional (only )
Each nephron has ___parts . Name -
2
Glomerulus
Renal tubule
Glomerulus is a tuft of ____ formed by the __ .
Capillaries
Afferent arteriole
Afferent arteriole is a fine branch of __.
Renal artery
Blood from the glomerulus is carried away by an_____
Efferent arteriole
__is formed by the afferent arteriole .
Glomerulus
Parts of renal tubule ( 2nd part of nephron )_
Bowman’s capsule
PCT
Henle’s loop
DCT
The renal tubule begins with a _walled _like structure called _____.
Double walled
Cup like
Bowman’s capsule
Bowman’s capsule is _waled .
Double
Bowman’s capsule encloses the ___
Glomerulus
Glomerulus along with the bowman’s capsule is called the_or __.
Malphigian body
Renal corpuscle
The renal tubule after Bowman’s capsule continues further to form a ____ network called _
Highly coiled
PCT
The __shaped HENLE’S loop is the next part (after PCT) of the renal tubule which has a _and an __part .
Hairpin
Descending
Ascending limb
The _limb of Henle’s loop continues as another __called _.
Ascending
Highly coiled tubular region
DCT
The _ of many nephrons open into a straight tube called COLLECTING DUCT .
DCTs
Many __converge and open into the RENAL PELVIS .
Collecting ducts
Many collecting ducts converge and open into the __ through __ in the _____ .
Renal pelvis
Medullary pyramids
Calyces
The parts of nephrons situated in the CORTICAL part of the kidney are -
3
Malphigian corpuscle
PCT
DCT
_part of nephron DIPS into the medulla .
Loop of henle
In __of nephrons , the loop of henle is too short and extends ______.
Majority
Only very little into the medulla
In MAJORITY of nephrons the HENLE’s loop is too short and extends only very little into the medulla . These nephrons are called -
Cortical nephrons
What are the 2 kinds of nephrons ? On what basis are they classified ?
2
Cortical nephrons -majority
Juxta medullary nephrons -few
Based on the length of henle’s loop dipping into the medulla
In some nephrons , the henle’s loop is __and runs deep into the medulla .they are called -
Very long
Juxta medullary nephrons
The ___emerging from the glomerulus forms a fine network of CAPILLARIES around the ___ .
Efferent arteriole
Renal tubule
The fine network of capillaries around the RENAL TUBULE formed from efferent arteriole are called ____
Peritubular capillaries
A minute vessel of ___ network runs parallel to the henle’s loop .
Peritubular capillaries
A __ of peritubular capillary network runs parallel to the henle’s loop forming a _ shaped ___.
Minute vessel
U -shaped
VASA RECTA
_is absent or highly reduced in CORTICAL NEPHRONS .
Vasa recta( becoz it runs parallel to the henle’s loop , which is highly reduced in cortical nephrons )
Vasa reacts arises from ___
Peritubular capillaries
Urine formation involves ____processes .name-
3
Glomerular filtration
Reabsorption
Secretion
The 1st step in urine formation -
Filtration of blood
The 1st step of urine formation is carried out by -
Glomerulus , hence the name GLOMERULAR FILTRATION
On an average __ blood is filtered by the kidneys per minute .
1100-1200ml per min
Blood filtered by the kidneys per minute constitutes roughly ___ of the blood pumped out by ____ in a minute .
1/5th
Each ventricle of the heart
The _____causes filtration of the blood .
Glomerular capillary blood pressure
The glomerular capillary blood pressure causes filtration of blood through ____layers .name -
3
Endothelium - of glomerular blood vessels
Basement membrane -in btw
Epithelium - of Bowman’s capsule
The epithelial cells of Bowman’s capsule are called -
Podocytes
Podocytes are _cells of ___.
Epithelial cells
Bowman’s capsule
Podocytes are arranged in an ____manner . Why ?
Intricate
To leave some minute spaces called - filtration slits or slit pores
Blood is filtered so finely through the 3 membranes , that almost all the constituents of __ except ___ pass onto the ____.
Plasma
PROTEINS
Lumen of Bowman’s capsule
Glomerular filtration is also called ____ . Why ?
Ultrafiltration
Becoz blood is filtered so finely through the 3 layers that all constitutes of plasma except proteins pass onto the lumen of Bowman’s capsule
____are not filtered by ultrafiltration .
Proteins
The amount of FILTRATE formed by the kidneys per minute is called -
Glomerular filtration rate
GFR in a healthy individual is _______ ml / min .
125 ml/min
GFR in an healthy individual is approx _____ litres /day .
180 litres / day
The kidneys have built-in mechanism for the regulation of GFR .T/F
T
An in-built mechanism for the regulation of GFR is Carrie out by the -
Juxta glomerular apparatus JGA
JGA is a special ___formed by the ___ modifications in the DCT and the afferent arteriole at the location of their contact .
Sensitive region
Cellular
JGA is formed by the cellular modifications in the __and ___at the junction of their contact .
DCT
Afferent arteriole
(Therefore , JGA is found in the kidney itself )
____activates the JG cell to release RENNIN .
FALL in GFR
What is the role of RENIN ?
Stimulates the glomerular blood flow and thereby , the GFR back to normal .
When is RENIN released and from where ?
When the GFR falls .
Released from JG cells -in the kidney
The comparison of the volume of the filtrate formed per day (180 L/day) with that of the urine released (1.5 L) , suggest that -
Nearly 99% of the filtrate formed has to be reabsorbed by the RENAL TUBULES .
Nearly 99% of the filtrate formed per day is reabsorbed . This process is called -
Reabsorption
The __cells in diff parts of the nephron perform reabsorption .
Tubular epithelial cells
The tubular epithelial cells in diff segments of the nephron perform reabsorption by _or _ mechanisms .
Active
Passive
Name the substances in the filtrate which are reabsorbed actively -
Glucose
Amino acids
Na+
Name the substances in the filtrate which are REABSORBED passively -
Nitrogenous wastes
Water ( in the initial segments of nephron )
Water is reabsorbed __in the ___ of nephron .
Passively
Initial segments
During urine formation , the tubular cells secrete substances like -__ , __and __into the FILTRATE .
H+
K+
Ammonia
Tubular secretion is also an imp step in __ . why ?
Urine formation
Maintenance of ionic and acid -base balance of body fluids
Tubular secretion maintains _ and __ balance of body fluids .
Ionic
Acid-base
PCT is lined by ___ which inc the SA for _.
Simple cuboidal brush border epithelium
Reabsorption
Which substances are reabsorbed by the PCT ?
Nearly all the essential nutrients
70 -80 % electrolytes
Water
(Max reabsorption )
PCT also helps to maintain the _and ___ of the body fluids .
pH
Ionic balance
PCT helps to maintain the pH and ionic balance of body fluids by _ of __,_and __ into the filtrate and by __ of ___from it .
Selective secretion H+ ions Ammonia K+ ions Absorption HCO3-
Selective secretion by PCT is done ____and absorption is done _____
Into the filtrate
From it
__is minimum in the ASCENDING LIMB of henle’s loop .
Reabsorption
__region plays a significant role in the maintenance of high ormolarity of MEDULLARY INTERSTITIAL FLUID .
Ascending limb of henle’s loop
Descending limb of henle’s loop is permeable to __and almost impermeable to ____.
Water
Electrolytes
The ascending limb is impermeable to __ but allows transport of _ in __ ways .
Water
Electrolytes
Both -active and passive ways
As the CONCENTRATED filtrate passes up the ascending limb , it gets _______ due to the _.
Diluted
Passage of electrolytes to the medullary fluid
Ascending limb plays a significant role in maintenance of __ of ___.
HIGH osmolarity
Medullary interstitial fluid
While moving down the descending limb , the filtrate is ____ . Reason -
Concentrated
Becoz water moves out ( not electrolytes )
Conditional reabsorption of Na + and water takes place in this segment -
DCT
DCT is capable of reabsorption of __and selective secretion of ___.
HCO3-
H+ , K+ , NH3
DCT is capable of reabsorption of HCO3- and secretion of H+,K+ and NH3 to maintain the ___ and ___balance in blood
pH
Sodium-potassium
_reabsorption of _and _ takes place in DCT .
Conditional
Na+
Water
Collecting duct extends from __ of kidney to _.
Cortex
Inner parts of medulla
Large amounts of water could be REABSORBED from __to produce a __.
Collecting duct
Conc urine
___ allows passage of small amounts of UREA into the medullary interstitium to keep up osmolarity .
Collecting duct
Collecting duct plays a role in the maintenance of ____ and __ of blood . How ?
pH
Ionic balance
By SELECTIVE SECRETION OF H+ and K+ ions
Collecting duct allows passage of ___ into the ___to keep up osmolarity .
Urea
Medullary interstitium
____have the ability to produce a CONC URINE .
Mammals
The ____and ____ play a significant role in the CONC of URINE .
Henle’s loop
Vasa recta
The flow of filtrate in the henle’s loop is in _____direction ,and thus forms a ____ .
Opposite
Counter current
The flow of filtrate in the ____of vasa recta is also in a ___pattern .
2 limbs
Counter- current
The proximity btw the henle’s loop and vasa recta , as well as the counter current in them help in maintaining an _____ towards the _____ .
Increasing osmolarity
Inner medullary interstitium
The osmolarity i the CORTEX is _____ and i the INNER MEDULLA is _____ .
300 mOsmolL-1
1200 mOsmolL-1
Osmolarity increases towards inner medullary interstitium
The main reason for th inc osmolarity towards the inner medullary interstitium -
1) proximity btw henle’s loop and vasa recta
2) counter current in them
The gradient ( 300 osmolarity in cortex and 1200 osmolarity in medulla ) is mainly caused by -
NaCl
Urea
____is transported by the ascending limb of henle’s loop which is exchanged with the __ limb of __.
NaCl
Descending limb
Vasa recta
NaCl is returned to the interstitium by __.
Ascending portion of vasa recta
Small amounts of UREA enter the____ which is transported back to the interstitium by the ______ .
THIN segment of ASCENDING limb of henle’s loop
Collecting tubule
The transport of substances fascinated by special arrangement of henle’s loop and vasa recta is called -
Counter current mechanism
Counter current mechanism helps to -
Maintain a CONC gradient in the medullary interstitium
The presence of the conc gradient in the medullary interstitium helps in -
easy passage of water from the COLLECTING TUBULE , thereby CONCENTRATING the filtrate ( urine )
Human kidneys can produce urine nearly __ times conc than the initial filtrate formed . How ?
4
Becoz of the conc gradient in the medullary interstitium due to the counter -current mechanism .
Osmolarity in the outer medulla -
600 mOsmolL-1
Counter current mechanism helps in the transport of which substances and how ?
NaCl and urea
1) NaCl is transported by the ascending limb of henle’s and is exchanged with the descending limb of vasa recta . NaCl is returned to the interstitium by the ascending limb of vasa .
2) small amount of urea enters the thin segment of the ascending limb of henle’s and is transported back to the interstitium by COLLECTING tubule .
The functioninof kidneys is efficiently monitored and regulated by ___ .
Hormonal feedback mechanism
The hormonal feedback mechanisms regulating kidney function involve ___, ____and to some extent , the____.
Hypothalamus
JGA
Heart
_in the blood are activated by changes in blood volume , body fliud vol or ionic conc .
Osmoreceptors
An ______ can stimulate osmoreceptors which stimulate the ____ to release ADH or vasopressin from the __.
Excessive loss of fluid from the body
Hypothalamus
Neurohypophysis
ADH facilitates ____ form __parts of the TUBULE , thereby preventing ___.
Water reabsorption
Latter parts (DCT , collecting duct )
Diuresis
What suppresse the ADH release to complete the feedback (which started with the release of ADH ) ?
An inc in body fluid vol can switch off the osmoreceptors ans suppress ADH release .
ADH can also affect the kidney function by its ____effects on ___.
Constrictors effects
Blood vessels
ADH causes ____in BLOOD PRESSURE . How ?
Increase
Due to its contractors activity on blood vessels
ADH inc / dec the GFR .
Inc
Becoz of the inc in constrictory activity of ADH , an increase in ___ can inc the___ and thereby the GFR .
Blood pressure
Glomerular blood flow
How can OSMORECEPTORS be activated ?
Changes in blood vol
Changes in body fluid vol
Changes in ionic conc
What happens when there is excessive loss of fluid form the body ?
1) Osmoreceptors are activated
2) they stimulate hypothalamus to release ADH from neurohypophysis .
3) ADH facilitates water reabsorption from the latter parts of tubule , preventing diuresis .
The JGA plays a ______role .
Complex regulatory role
What activates the JG cells to release RENIN ?
Fall in glomerular blood flow Or
Fall in glomerular blood pressure Or
Fall in GFR
JG cells are activated to release renin to inc / dec GFR ?
Inc
ADH is secreted hen GFR falls / rises ?
Falls
Renin converts ____ in blood to __ an further to ____.
Angiotensinogen
Angiotensin 1
Angiotensin 2
Aniotensinogen is released from the _____.
Blood
Angiotensin 2 is a powerful ____.
Vasoconstrictor
Function of angiotensin 2 -
1) Angiotensin 2 being a powerful vasoconstrictor, inc the glomerular blood pressure and thereby the GFR
2) activates the adrenal cortex to release ALDOSTERONE .
Angiotensin 2 activates the ___ to release ALDOSTERONE .
Adrenal cortex
Aldosterone causes reabsorption of ___and ___ from the ____ parts of the tubule .
Na+
H2O
Distal parts
Aldosterone dec / inc GFR .
Inc
Function of ALDOSTERONE released with the help of angiotensin 2 -
Causes reabsorption of Na+ and H2O from distal parts of the tubule .
It’s leads to an inc in blood pressure and GFR .
The complex mechanism that starts with JG cells is called -
Renin-angiotensin mechanism
How does renin -angiotensin mechanism inc GFR ?m
1) renin converts angiotensinogen to angiotensin 1 and angiotensin 2 . Angiotensin causes vasoconstriction and inc GFR
2) angiotensin2 activated release of aldosterone from adrenal cortex . Aldosterone causes reabsorption of Na + and H2O .
An inc in GFR ( blood flow ) to the ____of the heart can cause the release of ____ .
Atria
ANF ( atrial natriuretic factor )
ANF causes ______.
Vasodilation ( dilation of blood vessels )
ANF inc / dec blood pressure .
Dec
dec GFR
____acts as a check on renin- angiotensin mechanism .
ANF mechanism
Urine formed by the nephrons is ultimately carried to the ____ where it is stored till a ____ signal is given by the ___.
Urinary bladder
Voluntary
CNS
The voluntary signal by the CNS is initiated by -
Stretching of the urinary bladder as it gets filled with urine .
When the urinary bladder is stretched __send signals to the CNS .
Stretch receptors on the walls of the bladder
The CNS passes on ____to initiate the CONTRACTION of _____ of the bladder .
Motor messages
Smooth muscles
______of smooth muscles of bladder and simultaneous _____of the URETHRAL SPHINCTER causing the release of urine .
Conc
Relaxation
Release of urine is called ____ and the neural mechanism causing it is called ______ .
Micturition
Micturition reflex
An adult human excretes on an average ______ urine per day .
1 - 1.5 L /day
The urine formed is a light yellow coloured watery fluid which is slightly ___ and has a characteristic odour .
Acidic ( pH - 6 )
Odour
On an average , ____ of UREA is excreted out per day .
25 - 30 gm
Various conditions can affect the ____ of urine .
Characteristics
Analysis of urine helps in clinical diagnosis of many ____ as well as ____ .
Metabolic disorders
Malfunctioning of the kidneys
Presence of ___ and ___ in urine are indicative of DIABETES MELLITUS .
Glucose - glycosuria
Ketone bodies - ketonuria
Relaxation of _____ causes micturition .
Urethral sphincter
Other than kidneys , __ , ___and ____ also help in elimination of excretory wastes .
Lungs
Liver
Skin
Our lungs remove large amounts of co2 ( approx ____ /min ) and also significant quantities of _____.
200ml / min
Water every day
Liver secretes. -____ containing substances like ____
Bile Bilirubin Biliverdin Cholesterol Degraded steroid hormones Vitamins Drugs
The bile containing substances secreted by liver are removed from the body by -
Passed out along with digestive wastes
____and ___glands in the SKIN can eliminate certain substances through their secretions .
Sweat
Sebaceous
Sweat produced is a watery fluid containing -
NaCl
Small amt of UREA
Lactic acid
Primary function of sweat -
Facilitate a cooling effect on the body surface
But it also helps in the removal of some wastes
Sebaceous glands eliminate certain substances like __ ,__ and ___ through ____.
Sterols
Hydrocarbons
Waxes
Sebum
____provides a protective oily covering for the skin .
Secretions of sebaceous glands released through sebum
Small amounts of ___could be eliminated through SALIVA too .
Nitrogenous wastes
Malfunctioning of kidneys can lead to -
Accumulation of urea in the blood 🩸
Accumulation of urea in the blood is called _____ , which is highly harmful and may lead to _____.
Uraemia
Kidney failure
In case of uraemia , urea can be removed by a process called -
hemoDialysis
During the process of haemodialysis , the blood drained from a ___ is pumped into a _____ called ___.
Convenient artery
Dialysing unit
Artificial kidney
Blood drained from a convenient artery is pumped into a dialysing unit after adding __.
An anticoagulant. Like HEPARIN
The dialysing unit contain a ____surrounded by a ____ having the same composition as that of ___.
Coiled cellophane tube
Fluid ( dialysing fluid )
Plasma
The dialysing fluid has the same composition as that of plasma except te ___.
Nitrogenous wastes
The ___ cellophane membrane of the tube allows the passage of molecules based on _____.
Porous
Conc gradient
As ___are absent in the dialysing fluid , these substances freely move out ,thereby clearing the blood .
Nitrogenous wastes
The cleared blood is pumped back to the body through a ___ after adding _____.
VEIN
Anti-heparin
__is the ultimate method in the correction of ACUTE RENAL FAILURES (kidney failures )
Kidney transplant
A functional kidney is used in transplantation from a donor , preferably a_____, to minimise chances of _________ of the host .
Close relative
Rejection by the immune system
Name the disorder in which a STONE or INSOLUBLE mass of crystallised salts are formed within the kidney .
Renal calculi
Renal calculi is caused by the formation of ____ within the kidney .
OXALATES ( calcium oxalate crystals ) -stone or insoluble mass of crystallised salts
Inflammation of GLOMERULI of kidney -
Glomerulonephritis