Exam II-L9 Flashcards
What receptor is affected in CF?
Mutation in CFTR (chloride channel)
In CF, there is impaired chlorine transport, which leads to decreased secretion of ___ and increased uptake of ___ and ___
Less Cl secretion
More Na/water uptake
Why do individuals with CF frequently get infections?
Accumulation of mucus in lungs
Why do individuals with CF frequently have digestion and absorption problems?
Accumulation of mucus in pancreas causes blocked ducts (which deliver dig enzymes)
Where is SGLT2 expressed?
Function?
Express in kidney
Responsible for glucose reabsorption in kidney
SGLT inhibitors allow for excretion of excess ______ in the urine
blood glucose
True or False: SGL2 Inhibitors aid in weight loss and decrease BP
True
Where is dietary glucose absorbed? Via what transporter?
Intestine (SGLT1)
SGLT inhibitors block ___ from being reabsorbed in the kidneys
blood glucose
Which transporter facilitates the transfer of both glucose and sodium INTO the cell, with the energy of the sodium gradient
Symport SGLT 1
True or False: Glucose moves along its concentration gradient in the intestine, via Symport SGLT1
False - Glucose must move AGAINST its concentration gradient in the intestine, via SGLT1
Na/K Pump and GLUT 1 are examples of
Symporters/SGLT1
Does Symporter SGLT1 require ATP? Where does it find energy?
No
- Uses the energy of the sodium gradient
In SGLT1, Na/glucose are co-transported across apical membrane via SGLT. Excess sodium that has entered the cell is pumped out via: ____
NaK ATPase
In the presence of SGLT1, glucose is transported from the epithelial cell into the blood via a ______ on the basolateral membrane
glucose uniporter
What happens if SGLT1 is inhibited?
Diarrhea
What transporter does pancreas use to absorb glucose?
GLUT2
In DM, glucose increases and travels to brain, liver, pancreas, and GLUT1-3. Following this, pancreas absorbs glucose but no ___ is release. Therefore: glucose is not transported into muscle/tissue via ___
insulin; GLUT4
True or False: In patients with DM, kidneys excrete excess glucose into urine to reduce blood glucose levels, leads to glucosuria
True
What transporter does insulin use to transport glucose into muscle and adipose?
GLUT4
Which uniport facilitates transport of glucose into the cell, in favor of its concentration gradient?
GLUT4
What does glucose transport require to work?
Glucose gradient
Does GLUT4 require ATP?
If no, what does it require?
No
- Requires insulin to reach the cell membrane
True or False: Binding of insulin to its receptors promotes recruitment of glucose transporters from intracellular pool to cell membrane
True
Does glucose transport require ATP?
No
Where are glucose uniporters located?
muscle and fat
Do Antiporters require energy? ATP?
Antiporters require energy, but NOT ATP
____: use energy generated during transport of a molecule along its concentration gradient to transport a second molecule against its concentration gradient - both move in opposite directions
Antiporters
Sodium/Calcium move via ____
anitporter
True or False: Symporters require ATP, but not energy
False - symporters do NOT require ATP but do require energy
____: uses energy made during transport of a molecule along its concentration gradient to transport a second molecule against its concentration gradient - both move in same directions
Example of a symporter?
SGLT
Do symporters require ATP? energy?
Symporters require energy - not ATP
Symporters and Antiporters are examples of ____
P, V and F, and ABC Pumps are examples of
secondary active transport
primary active transport
Secondary active transport requires ___ but not ___
energy; ATP
What type of transporter can pump out drugs and make a cancer cell resistant to this drug by limiting amount of drug that gets into the cell?
ABCB1 Pump (also known as MDR)
