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Biochemistry I/II > Exam II-L9 > Flashcards

Exam II-L9 Flashcards

1
Q

What receptor is affected in CF?

A

Mutation in CFTR (chloride channel)

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2
Q

In CF, there is impaired chlorine transport, which leads to decreased secretion of ___ and increased uptake of ___ and ___

A

Less Cl secretion
More Na/water uptake

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3
Q

Why do individuals with CF frequently get infections?

A

Accumulation of mucus in lungs

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4
Q

Why do individuals with CF frequently have digestion and absorption problems?

A

Accumulation of mucus in pancreas causes blocked ducts (which deliver dig enzymes)

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5
Q

Where is SGLT2 expressed?
Function?

A

Express in kidney
Responsible for glucose reabsorption in kidney

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6
Q

SGLT inhibitors allow for excretion of excess ______ in the urine

A

blood glucose

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7
Q

True or False: SGL2 Inhibitors aid in weight loss and decrease BP

A

True

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8
Q

Where is dietary glucose absorbed? Via what transporter?

A

Intestine (SGLT1)

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9
Q

SGLT inhibitors block ___ from being reabsorbed in the kidneys

A

blood glucose

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10
Q

Which transporter facilitates the transfer of both glucose and sodium INTO the cell, with the energy of the sodium gradient

A

Symport SGLT 1

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11
Q

True or False: Glucose moves along its concentration gradient in the intestine, via Symport SGLT1

A

False - Glucose must move AGAINST its concentration gradient in the intestine, via SGLT1

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12
Q

Na/K Pump and GLUT 1 are examples of

A

Symporters/SGLT1

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13
Q

Does Symporter SGLT1 require ATP? Where does it find energy?

A

No
- Uses the energy of the sodium gradient

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14
Q

In SGLT1, Na/glucose are co-transported across apical membrane via SGLT. Excess sodium that has entered the cell is pumped out via: ____

A

NaK ATPase

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15
Q

In the presence of SGLT1, glucose is transported from the epithelial cell into the blood via a ______ on the basolateral membrane

A

glucose uniporter

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16
Q

What happens if SGLT1 is inhibited?

A

Diarrhea

17
Q

What transporter does pancreas use to absorb glucose?

A

GLUT2

18
Q

In DM, glucose increases and travels to brain, liver, pancreas, and GLUT1-3. Following this, pancreas absorbs glucose but no ___ is release. Therefore: glucose is not transported into muscle/tissue via ___

A

insulin; GLUT4

19
Q

True or False: In patients with DM, kidneys excrete excess glucose into urine to reduce blood glucose levels, leads to glucosuria

A

True

20
Q

What transporter does insulin use to transport glucose into muscle and adipose?

A

GLUT4

21
Q

Which uniport facilitates transport of glucose into the cell, in favor of its concentration gradient?

A

GLUT4

22
Q

What does glucose transport require to work?

A

Glucose gradient

23
Q

Does GLUT4 require ATP?
If no, what does it require?

A

No
- Requires insulin to reach the cell membrane

24
Q

True or False: Binding of insulin to its receptors promotes recruitment of glucose transporters from intracellular pool to cell membrane

A

True

25
Q

Does glucose transport require ATP?

A

No

26
Q

Where are glucose uniporters located?

A

muscle and fat

27
Q

Do Antiporters require energy? ATP?

A

Antiporters require energy, but NOT ATP

28
Q

____: use energy generated during transport of a molecule along its concentration gradient to transport a second molecule against its concentration gradient - both move in opposite directions

A

Antiporters

29
Q

Sodium/Calcium move via ____

A

anitporter

30
Q

True or False: Symporters require ATP, but not energy

A

False - symporters do NOT require ATP but do require energy

31
Q

____: uses energy made during transport of a molecule along its concentration gradient to transport a second molecule against its concentration gradient - both move in same directions

A
32
Q

Example of a symporter?

A

SGLT

33
Q

Do symporters require ATP? energy?

A

Symporters require energy - not ATP

34
Q

Symporters and Antiporters are examples of ____

P, V and F, and ABC Pumps are examples of

A

secondary active transport

primary active transport

35
Q

Secondary active transport requires ___ but not ___

A

energy; ATP

36
Q

What type of transporter can pump out drugs and make a cancer cell resistant to this drug by limiting amount of drug that gets into the cell?

A

ABCB1 Pump (also known as MDR)

Biochemistry I/II (23 decks)

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