Exam II Flashcards
What are the 7 functions of the skeletal system?
Support, protection, movement, electrolyte balance, acid/base balance, blood formation, detoxification
What are the 4 bone shapes?
Short, long, irregular, flat
Where is spongy bone found?
fills the head of the long bones and forms the middle layer of flat bones
Where is compact bone found?
a denser calcified tissue with no visible spaces and it forms the external surfaces of all bones
What are the structures in an osteon?
canal, lamellae, haversian canal, osteocytes
Medullary cavity
bone marrow cavity
Nutrient Foramina
blood vessels penetrate into the bone through these openings
What is the difference between the periosteum and endosteum?
The periosteum lines the external bone surface while the endosteum lines the internal marrow cavity, covers the honeycombed surfaces of spongy bone, and lines the canal system
What are perforating fibers?
collagen fibers of the outer layer of the periosteum that penetrate into the bone matrix as part of the periosteum’s attachment from muscle to tendon to bone
Why is the periosteum so important for bone growth?
The periosteum is so important for bone growth because of its inner layer of osteogenic cells
4 bone cells
osteogenic cells, osteoblasts, osteocytes, osteoclasts
osteogenic cells
stem cells that give rise to most other bone cells; they are found in the endosteum, the inner layer of the periosteum, and the central canals
osteoblasts
bone-forming cells; they synthesize the soft organic matter of the bone matrix, which hardens by mineral deposition
osteocytes
former osteoblasts that have become trapped in the bone matrix they deposited. Resorb or deposit bone matrix, contributing to the homeostasis of bone density and load is applied to a bone
osteoclasts
bone-dissolving cells found on the bone surfaces. Bone remodeling results from the combined action of osteoclasts and osteoblasts
What is the bone matrix made up of?
calcium, phosphate, and hydroxapatite
First step in bone fracture repair
Formation of a hematoma (clot) and granulation tissue: blood vessels are severed by a fracture; the blood forms a clot called a fracture hematoma. Fibrobalsts, macrophages, osteoclasts, and osteogenic cells invade the tissue, along with blood capillaries, converting the clot to a mass called granulation tissue
Second step in bone fracture repair
Fibroblasts deposit collagen while some osteogenic cells become chondroblasts and produce patches of cartilage called soft callus
Third step in bone fracture repair
Conversion to hard callus: Superficial osteogenic cells become osteoblasts, which a bony collar called the hard callus around the fracture. The hard callus acts as a temporary splint; it takes 4 to 6 weeks for a hard callus to form.
Fourth step in bone fracture repair
Remodeling: The hard callus perisits for 3-4 months, while osteoclasts dissolve small fragments of broken bone, and osteoblasts deposit spongy bone to bridge the gap
Metaphysis
The region of transition from cartilage to bone at each end of the primary marrow cavity
5 zones of mataphysis
done of reserve cartilage, zone of cell proliferation, zone of cell hypertrophy, zone of calcification, zone of bone deposition
zone of reserve cartilage
hyaline cartilage has not yet begun to transform into bone (no action)
zone of cell proliferation
chondrocytes multiply and arrange themselves into longitudinal columns of flattened lacunae (hyperplasia of chondrocytes, cartilage lengthens)
zone of cell hypertrophy
chondrocytes cease dividing and enlarge
zone of calcification
minerals are deposited in the matrix and calcify the cartilage (calcium fortification)
zone of bone deposition
walls between lacunae break down and chondrocytes die; osteoblasts line up along the walls of the channels and begin depositing concentric lamellae; osteoclasts dissolve the temporarily calcified cartilage. (replacement of cartilage with bone)
Interstitial growth
the growth of cartilage from within the metaphases (from the center out)
Appositional growth
deposition of new tissues at the surface
What are the hormones involved in bone remodeling?
calcitriol, calcitonin, parathyroid hormone (PTH)
Where are the hormones involved in bone remodeling made?
calcitriol: produced by sequential action of the skin, liver, and kidneys
calcitonin: secreted by C cells of the thyroid gland
PTH: secreted by the parathyroid glands