Exam II Flashcards
Cognitive aging is what kind of lifelong process?
Developmental, occurring from birth to death
Cognitive aging occurs within a frame work of what?
Gains, declines, and stability
Cognitive aging is impacted by what?
Diet, exercise, health habits, and education
What are other factors that affect cognition?
-Neurobiological influences (related to disease process, sensory systems, auditory/visual systems)
-Affective influences (anxiety, fatigue, pain, depression)
Sensory processes
Transmits stimuli from environment to neutral structures, older age declines auditory and visual processing
Perception
Assign meaning to stimuli, older adults utilize situational context and experience to maintain perceptual abilities necessary to function
Sustained attention
Direct to single task, no change comparing younger to older adults
Selective attention
Direct to a task while simultaneously using resources to ignore distracting info, probably no age change
Alternating attention
Switching between two or more tasks, older adults have more difficulty
Divided attention
Allocate attentional resources to two or more tasks at the same time, declines with age
Types of memory
Sensory, short-term, working, long-term
MOST decline with age!!
Sensory memory
Stores incoming info for a very short time
Short-term memory
15-20 seconds stored without rehearsal
Working memory
Stores, maintains, actively manipulates information
Long-term memory (2 kinds)
Declarative- verbal based memory
Semantic- general world knowledge not linked to a specific learning episode
Procedural (non-declarative) memory
-Stores information for motor based skills and behaviors
-Well preserved in later life
Prospective memory
Remember future oriented or scheduled tasks without the use of external memory aids
Executive functioning
-Reasoning, decision making, problem solving, judgement, abstract thought, and logic
-SIGNIFICANT differences from younger to older as task complexity increases as additional cognitive resources are needed
Problem-solving
Older adults tend to use less efficient strategies, persist longer in using erroneous solutions, and produce more errors
Everyday cognition
Utilize cognitive processes in real world contexts, fewer age related differences
Language production and speech comprehension
Older adults OUTPERFORM younger in message production and discourse- like storytelling
Expertise
-High level of skill/knowledge in one area – problem solving, reasoning, memory
-Maintains in later life and helps compensate for other deficits
Implicit processing
-Unintentional, occurs with awareness, effortful- requires moderate to substantial cognitive resources
-Minimal age young to old
Explicit processing
-Intentional, occurs with awareness, effortful – requires moderate to substantial cognitive resources
-Some age related decline in skill
Intellectual abilities (2 types)
-Fluid intelligence – ability to use abstract reasoning, flexibly shift mental set (decline begins around age 70)
-Crystallized intelligence- accumulation of knowledge, experience, acculturation (increases throughout life and maintains in old age)
How do we optimize cognition in later life?
-Physical activity (aerobic, strengthening, balance, and flexibility)
-Mentally stimulating activities
-Social engagement
Benefits of physical activity
Increased cerebral flow, increased neural growth hormone, increased insulin-resistant growth factor, increased brain volume
Benefits of mentally stimulating activities
-Novel and mentally challenging to promote neural growth, development, and plasticity
-Building cognitive reserve reduces chance that ADLs will surpass available resources
Benefits of social engagement
-Promote connectedness by maintaining social contacts and participating in social activities
-Social isolation and lack of perceived support has a detrimental effect on psychological well-being
Mild Cognitive Impairment (MCI)
-The changes in memory and other areas of cognitive function that may be seen in healthy older adults of at least average intellectual functioning
-Not a strong impact on ADLs, IADLs, or leisure
Dementia demographics
4.3% of adults age 70-74 diagnosed with dementia
47.5% of adults over 90 diagnosed with dementia
What is the most common form of dementia?
Alzheimer’s disease (5.2 million living with AD data from 2014)
What are the characteristics of dementia?
-Cannot meet everyday demands of life
-Affects cognition, behavior, and occupational performance
-Irreversible and often progressive
-Memory loss not always first sign
(T/F) Is dementia the inevitable part of aging?
False
(T/F) Dementia is an acquired, persistent impairment in multiple areas of intellectual functioning due to delirium.
False- NOT due to delirium
What is the impact of dementia on behavior and occupational performance?
-Deterioration in their day to day functioning, ability to engage in meaningful occupations decreases
-Safety becomes a concern, increase in need for assistance, support, or supervision
What impact does dementia have on family?
-Informal caregivers have an increase in stress as well as an impact on physical, mental, and emotional well-being
-Financial situations
What are some reasons individuals with dementia are admitted to long term care?
Need skilled care, deterioration of caregiver health, dysregulation and psychotic behaviors/symptoms
Delirium definition
Alteration of mental status characterized by an inability to appreciate and respond normally to the environment
Difference between delirium and dementia
Delirium is often reversible, viewed as a medical problem that can be diagnosed and treated
Delirium makes up ___% of all dementias, ___% are not reversible
13%, 87%
Causes of delirium
-Thyroid disorders
-UTI
-Electrolyte imbalances
-Hormonal imbalances
-Normal Pressure Hydrocephalus (NPH)
-Tumors
-Stroke
-Intoxication
-Withdrawal from substances
-Depression
-Systemic illness
-End stage liver disease
While delirium makes up 13% of all dementias, what are types that make up the remaining 87%?
-Alzheimer’d disease
-Vascular dementia
-Frontal-temporal dementia
-Lewy-body dementia
-Korsakoff’s syndrome
-Huntington’s disease
-AIDS related
-Parkinson’s with dementia
-Multiple sclerosis
Cause of vascular dementia (VaD)
-Strokes or other vascular disorders that decrease blood flow to the brain
-Single brain infarct or multiple lesions
Can a person have VaD and AD? (mixed)
Yes
Subcortical ischemic vascular dementia (SIVD)
Numerous discrete subcortical lesions
Vascular cognitive impairment (VCI)
-Cognitive changes that occur due to vascular lesions
-Can be treated and doesn’t always turn into VaD
-Recognition of VCI may allow for early diagnosis to avoid progressive cog impairment to dementia
Dysexecutive syndrome
-Hallmark of VCI and VaD
-Problems with attention, working memory, planning, and sequencing
Who is at risk for VCI or VaD?
10-30% of all dementias
Advanced age, male, history of stroke, hypertension
Cause of dementia with Lewy bodies (DLB)
Presence of leeway bodies, damaged nerve cells, amyloid and plaque formation similar to AD
What are Lewy bodies?
Clumps of abnormal protein particles
Hallmark- round neurofilament inclusion bodies
Core features of DLB
-Hallucinations (recurrent and well formed)
-Parkinsonian symptoms (gait, tremors, rigidity, bradykinesia)
-Cognitive fluctuations (prominent attention deficits)
-Progressively worsens
-Cognitive features preceded Parkinsonian features (motor)
With DLB what becomes apparent over time?
Memory impairment
More prominent features of DLB
Deficits on attention, visuospatial and executive function
How is clinical diagnosis strengthened for DLB?
-Repeated falls
-Nonvisual hallucinations
-Delusions
-Fainting
-Transient losses of consciousness
Who is most likely to be diagnosed with DLB?
Men over 65 2x more like
DLB is ___% of all dementias
14-20%
Frontotemporal dementia (FTD) age onset
57 years
Range 51-63
Symptoms of FTD
-Gradual but prominent changes in personality
-Behavioral disturbances and changes in how they interact socially
-Can fail to demonstrate basic emotions
-Neglect personal hygiene or dress inappropriately
-Loss of insight and difficulty planning, problem solving
-Little initiation, lack of spontaneity, difficulty regulating behaviors
(T/F) FTD is not a common dementia
False- most common after AD and DLB
(T/F) Patients with FTD have better cued recall and recognition than patients with AD
True
When does dementia typically develop in patients with Parkinson’s?
-Slowly, roughly 10 years after Parkinson’s diagnosis, cognitive skills diminish first
What is the distinguishing feature between PDD and DLB?
Time sequence of symptoms
Parkinson’s disease with dementia (PDD) cognitive impairments
-Global, attention
-Executive function
-Poor performance on speed tests
-Difficulty initiating
-Decreased tasks requiring delayed recall
-Semantic knowledge
-Frontal executive functions
-Speech/language/visiospatial functions
-Difficulty with specific areas of memory
-Changes in executive function (planning, initiation, organization, memory retrieval)
Alzheimer’s disease (AD)
Intellectual impairment/behavior and personality
Irreversible and progressive
Risk factor for AD
Advancing age, serious head injury with loss of consciousness. genetic factors
Diagnosis of AD
Must demonstrate a decline in three or more of the following
-Memory
-Language
-Perception (especially visuospatial)
-Praxis
-Calculations
-Conceptual or Semantic Knowledge
-Executive Functions
-Personality or social behavior
-Emotional awareness or expression
Is memory impairment a required symptoms for diagnosis of AD?
No
Pathology of AD
-Neuritic plaques and neurofibrillary tangles in neocortex and hippocampus of the brain (seen on autopsy) can see shrinkage in brain
-Neurotransmitter deficits primarily in the cholinergic and noradrenergic and serotonergic systems are also evident
-7-20 year course
What happens over time to the brains of patients with AD?
The brain shrinks
Important AD facts
-AD is highly associated with aging, but not income
-Doesn’t discriminate
-Most of the AD population is female
-The elderly population with AD is less educated than the general elderly population
-51% of nursing home residents suffer from dementia, 1/3 have AD
What is the scale used to assess functional abilities in a patient diagnosed with AD?
Functional Assessment Scale (FAST)
Stage 1 of FAST
No difficulty either subjectively or objectively
Stage 2 of FAST
-Complaints of forgetting location of objects
-Subjective work difficulties
Stage 3 of FAST
-Decreased job functioning evident to co-workers
-Difficulty in traveling to new locations
-Decreased organizational capacity
State 4 of FAST
-Decreased ability to perform complex tasks
Stage 5 of FAST
-Requires assistance in choosing proper clothing to wear for day, season, or occasion
Stage 6 of FAST
-Occasionally or more frequently over the past weeks for the following:
A. Improperly putting on clothes w/out assistance or cueing
B. Unable to bathe properly
C. Inability to handle mechanics of toileting
D. Urinary incontinence
E. Fecal incontinence
Stage 7 of FAST
A. Ability to speak limited to approx. less than or equal to 6 intelligible different words in course of average day or in intensive interview
B. Speech ability is limited to use of single intelligible word in an average day or in intensive interview
C. Ambulatory ability is lost
D. Can’t sit up w/out assistance
E. Loss of ability to smile
F. Loss of ability to hold up head independently
Neuromuscular changes with age
-Decrease in muscle strength and power
-Decrease in skeletal muscle mass
-Decrease in number of functional motor units
-Changes in postural alignment
-Bone and cartilage changes
-Changes in balance and gait
-Decrease in max speed of movement and initiation in response to stimuli
-Increase in threshold for vibration sensation (decreased sensitivity)
-Decrease in proprioception
Continuum of functioning
Physically elite, physically fit, physically independent, physically frail, physically dependent
Physically elite
Train on a regular basis in sports competitions, continue to work in demanding occupation
Physically fit
May still work, may participate in activities with folks younger than them, continue to exercise regularly
Physically independent
Participates in IADLs and is still active in leisure and hobbies. May have one+ chronic conditions, function independently
Physically frail
Lives independently with some assist, may be unable to engage in some IADLs
Physically dependent
Cannot perform some ADL/IADL, requires institutional care or full-time assistance
Definition of strength
Force of muscle contractions and ability to generate force quickly
Definition of power
Timing and coordination
Why do strength and power decrease with aging?
-Decrease in number and diameter in myofibrils and certain types of muscle fibers
-Neurological changes that control muscle contraction
What changes occur in strength with aging?
-Minor until age 60, then becomes more rapid
-Isometric & Concentric strength in UE declines less than LE
What changes occur in power with aging?
-Decreases more quickly than strength
-10% greater rate of decrease than strength
-Example of functional activity that requires power is walking or standing up from a chair – timing and coordination of that muscle contraction