Exam FINAL: System Diseases Flashcards
This natural defense of the skin creates a tough, waterproof layer
Keratin
This natural defense of the skin allows for new skin every 20-40 days
Skin sloughing
This natural defense of the skin is a low pH, high lipid protector, essentially the same as ear wax
Sebum
This natural defense of the skin is a low pH, high salt defense.
Sweat
This natural defense of the skin is an enzyme that digests the peptidoglycan of bacterial organisms
Lysozyme
Propionibacterium acnes, Corynebacterium spp., Micrococcus spp., Staphylococcus spp., Streptococcus spp., and yeasts are examples of what?
Normal skin flora
This is the organism that causes acne
Propionibacterium acnes
Propionibacterium acnes is Gram positive or Gram negative?
Propionibacterium acnes is Gram +
What does Propionibacterium acnes do?
Digests sebum, attracts neutrophils
How are lesions formed when infected with Propionibacterium acnes?
Neutrophil digestive enzymes caues lesions, or “pus pockets”
This treatment for acne acts by drying plugged follicles and killing microbes. What is a downside of it?
Benzoyl peroxide. It is basically a bleach on your skin.
This is an antibiotic treatment for acne.
Tetracycline
How does Accutane work for acne? What are problems with it?
It inhibits sebum formation. It has many severe side effects. (How is it even legal?!)
What organisms cause impetigo?
Staphyloccocus aureus and Streptococcus pyogenes
This disease is characterized by peeling, crusty skin, and is very contagious.
Impetigo
What disease does SSSS stand for, and what is its cause?
Staphylococcal Scalded Skin Syndrome is caused by Staphylococcus aureus
This non-deadly, but very painful, disease causes large red blisters on the skin that peel off in sheets.
SSSS
Enzymes produced by an organism are _____, or things that allow an organism to produce disease
virulence factors
This is the most treated pathogen currently
Staphylococcus aureus
This is the organism that causes necrotizing fasciitis
Streptococcus pyogenes
Enzymes produced by Streptococcus pyogenes in necrotizing fasciitis cause what action?
Tissue digestion
What may necrotizing fasciitis lead to, as correlated with a drop in blood pressure?
Toxic shock
What is the mortality rate for necrotizing fasciitis? What is the general treatment plan?
30-70% mortality
Surgical removal/amputation of limbs is most appropriate due to the rapid rate of spreading
What organism causes Rocky Mountain Spotted Fever?
Rickettsia rickettsii
What kind of organism is Rickettsia rickettsii?
A gram negative bacillus or coccobacillus
How is Rocky Mountain Spotted Fever spread? Where is it generally found?
Transmitted by tick bites. Mostly found in the Eastern Atlantic states.
What causes the red to black rash seen with Rocky Mountain Spotted Fever? What is happening to to cause this?
Petechiae (hemmorhaging)
The capillaries are degraded by the organism.
Besides the red to black rash, what are 4 symptoms of Rocky Mountain Spotted Fever?
Fever, Chills, Headache, Muscle Pain
What is unique about Rickettsia rickettsii that caused it to be difficult to discover? What kind of parasite is it?
It is an obligate intracellular parasite (needs a host to survive). It does not grow in a culture, therefore was hard to initially discover.
What does Rickettsia rickettsii depend on it’s host for?
It needs to obtain nutrients, NAD+, and CoA from the host, as it does not have it for itself. It uses this to complete cellular respiration.
What binding action does Rickettsia ricketsii have on the host cells, and where does it go?
It binds to cell surface, taken into endothelial cells. It escapes from a phagosome into the cytoplasm.
How is Rocky Mountain Spotted Fever diagnosed?
How is it treated?
Diagnosed using PCR, or other molecular methods
Treated with long course of antibiotics
These are rashes associated with elevated lesions filled with fluid
Vesicular or pustular rash
What was the overall death rate of smallpox, historically? What group of people were more likely to die?
20-80% death rate
Children more likely to die
What disease is the only disease completely eradicated by vaccinations? When was is eradicated?
Smallpox in 1980
What are problems with the vaccine for smallpox?
It’s incredibly harsh, death possible, amputations from infected limb, considered a bioterrorism agent
What virus causes chickenpox?
Varicella-zoster
Where does local infection of chickenpox reside?
In lymph nodes in the neck
What symptoms occur with lymphocyte associated viremia?
Fever, malaise
These are rashes associated with flat to slightly raised colored bumps
Maculo-papular rashes
What are the 2 physical observable symptoms of measles?
Koplik spots and skin rash
What is the worldwide leading cause of vaccine-preventable death among children?
Measles
What is the measles death rate in developed countries? What is it among malnourished children?
1-5%, and 10-30% among malnourished children.
What are examples of health complications from measles?
pneumonia, diarrhea, encephalitis
What happens when a pregnant woman contracts Rubella? What symptoms does it cause?
Congenital Rubella Syndrome causes small birth weight, blindness, hearing loss, mental retardation, heart problems in the infant
What provides restricted entry into the brain for microorganisms, medications, and the immune system?
The blood-brain barrier
This is inflammation of the brain
Encephalitis
This is inflammation of the membranes surrounding the brain and spinal cord
Meningitis
This strain of bacteria causes bacterial meningitis, generally affecting infants and newborns
Haemophilus influenzae type b
This strain of bacteria causes bacterial meningitis, generally affecting children between 1 month-4 years old, and the elderly
Streptococcus pneumoniae
This strain of bacteria causes bacterial meningitis, generally affected college students.
Neisseria meningitidis
True/False: Streptococcus pneumoniae is a Gram + diplococci
TRUE: Streptococcus pneumoniae is a Gram + diplococci
Virulent strains of Streptococcus pneumonia are ___. This means _____.
Encapsulated. This means it has the ability to cause disease.
The subunit vaccine for Streptococcal meningitis acts how?
Induces opsonizing antibody to the capsule of the pathogen
These are immune cells for the brain and CNS (2 ans)
Microglial cells and microphages
How does Neisseria meningitidis enter the body to cause disease?
Enters via droplets through the nasal cavity
How many Americans get meningococcal meningitis from Neisseria meningitidis each year? How many die? How many have long term disabilities resulting?
Meningococcal meningitis (Neiserria meningitidis)
2,500 Americans/year
10-15% die
20% long-term disability
What type of vaccine is used for Neisseria meningitidis and how does it work?
Subunit vaccine that induces opsonizing antibody to capsule
This is the name of the ORGANISM that is also known as the Brain Eating Amoeba
Naegleria fowleri
This is the name of the DISEASE caused by the brain eating amoeba
Naegleria Meningoencephalitis
Where is Naegleria fowleri found?
In fresh, warm water (ponds, ground water, etc)
When do symptoms appear after infection with Naegleria fowleri? What are the symptoms?
3-10 days after exposure.
Severe headache, fever, stiff neck, dementia, coma
What is the route of passage for Naegleria fowleri to infect a human?
Initially up the nose, then makes way into brain
What does Naegleria fowleri do to a human?
Feeds on brain and spinal tissue, destroying it. Death occurs within 10 days.
What is the treatment for Naegleria meningoencephalitis?
There is no treatment. Death is likely (>95% mortality rate)
This is the name of the organism that causes toxoplasmosis.
Toxoplasma gondii
What type of organism is Toxoplasma gondii?
Flagellated protozoan parasite
What is the primary reservoir for Toxoplasma gondii?
Cats
What are two groups of people that are at risk of infection by Toxoplasma gondii?
Pregnant people (fetus at risk) and people with AIDS
What can happen to fetuses that are exposed to Toxoplasmosis infection? (3 ans)
Liver damage, brain abnormalities, blindness
What organism causes Leprosy (Hansen’s disease)?
Mycobacterium leprae
This disease causes change in skin pigmentation, loss of sensation, potentially loss of limbs.
Leprosy (Hansen’s disease)
This animal is a carrier of Mycobacterium leprae.
Armadillo
Where do Mycobacterium leprae multiply and thrive within the body?
In macrophages. They escape the phagolysosome and thrive within these cells.
Is Leprosy treatable? If so, how?
Yes, it is a long, slow treatment process with a drug cocktail
How is rabies virus different from other viruses?
Most viruses have a very narrow window of infection potential, while rabies can infect any mammal
Human “dumb” rabies presents with these symptoms. (5)
Fever, confusion, anxiety, encephalitis, death
Animal “furious” rabies presents with these symptoms. (4)
Wandering, aggression, biting, salivating
What is hydrophobia related to rabies
Fear of water. Perhaps due to inability to swallow saliva
How is rabies diagnosed?
Must be diagnosed post-mortem. Brain biopsy will show plaques in the brain indicative of Rabies infection.
What is the name of the plaques found in the brain of a rabies infected animal?
Negri bodies
What is the treatment and mortality rate of rabies infection in the brain?
There is no treatment once the brain reaches the brain. The mortality rate is nearly 100%
Poliovirus, an “enterovirus” has an ___ ___ shell that protects it from ___.
icosahedra capsid shell that protects it from digestion
What disease is caused by Poliovirus? What are its symptoms?
Poliomyelitis; Paralysis
What is the best way to prevent poliovirius?
Safe, effective vaccine (PV-1,2,3)
What is the name of the organism that causes tetanus?
Clostridium tetani
What is unique aboutu the morphology of the Clostridium tetani cells?
They have a tennis racket shape, sending their spores to one side of the cell to give this appearance
What causes the symptoms of Tetanus once the bacteria makes entry into the host? What symptoms are caused?
The bacterial invasion releases bacterial toxins, causing rigid paralysis.