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BASIG q1 > Exam 6 > Flashcards

Exam 6 Flashcards

1
Q

what is this and what does it show CD19 20 positive or negative

A

reed sternberg cell shows hodgkins lymphoma

negative

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2
Q

what is this and what does it show

A

russel bodies in plasma cells - shows plasma cell neoplasm dyscrasis multiple myeloma
- monoclonal gamma globulin

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3
Q

Th1
-cell surface glyco proteins
-secretions

A

cell surface glyco proteins: CD4 and TCR
-secretions: Interluekin 2
IFN gama

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4
Q

Th2
-cell surface glyco proteins
-secretions

A

cell surface glyco proteins: CD4 and TCR
-secretions: Interluekin 4
&5

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5
Q

Tc
-cell surface glyco proteins
-secretions

A

cell surface glyco proteins: CD8 CD95L TCR
-secretions: Perforin Granzyme

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6
Q

Tr
-cell surface glyco proteins
-secretions

A

cell surface glyco proteins: CD4 CD25 TCR
-secretions: Inter luekin 10

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7
Q

Somatic Recombination occurs on the alpha chain of the TCR and at what stage (pro, pre, immature, mature)

Somatic Recombination occurs on the beta chain of the TCR and at what stage (pro, pre, immature, mature)

what cell is double positive (pro, pre, immature, mature)

A

alpha chain in the pre T
beta chain in the pro T
immature

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8
Q

mature cells hace what CD

A

CD 4 or CD 8

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9
Q

what binds to CTLA-4 and what does it do when it bind

A

CTLA-4 on the t cell binds to B7 to stop proliferation

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10
Q

what binds to cd28

A

CD28 is on T cell and it binds to B7 on the APC cell to cause proliferation

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11
Q

Explain the activation/ maturation of T cells

A
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12
Q

Cancer pt are given ____ to make agressive T cell

A

IL 2

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13
Q

inhibiting NFAT does what

A

causes immuno supression no proliferation activation of T cells —- cyclosporins

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14
Q

what starts proliferation of T cells … aka what binds to start proliferation

A

IL 2

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15
Q

what causes the cell to produce cyclins

A

IL 2 to IL2 receptors

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16
Q

after proliferation what two types of t cells are produced (which are shorter lived)

A

effector (shorter lived)
memory T (long lived)

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17
Q

draw types of effector Helper cells and what they secrete

A
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18
Q

what cells have FAS receptor and what cell hav FASL

A

all nucleated cells have FAS
CTL cd8 + bind to it

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19
Q

what is released if macrophage cant digest something and what does this activake

A

IL 12
activate NK cells

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20
Q

what is the first line of defense in viruses,
what does this cause
innate or adaptive

A

inhibition of intfection by releasing INF-a IFN-B
* antiviral mech
* increase MHC 1exp
* stimulate NK

innate

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21
Q

what activates NK

A

-INF beta and alpha
-IL12
-IL 15

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22
Q

sti

Central memory and effector memory difference

A

central
* secondary lymph tissue
* proliferate quick
Effector
* peripheral
* cecrete cytokines
* DONT PROLIFERATE

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23
Q

which cells express CD19
which cells express heavy chain and surrogate

A

proB cells which is the eliest
pre- b

24
Q

where does positive selection occur for B cells

A

periphery

25
Q

what is anergic and what cells become this

A

unresponsive cells thtat show low levels of IgM
b cells with weak interaction to cell antigen

26
Q

what cells become clonally ignorant

A

self reactive but done respond have ig D and IGM

27
Q

what needs to bind so that way B cells activate

A

ag to BCR
(Th2)TCR to MHC 2
(Th2) CD40L to CD40

28
Q

what cells show CD21

A

mature B cells

29
Q

what is peripheral tolerance

A

mechanisms to get rid of self reactive lymphocytes

30
Q

where does affinity maturation occur of b cell

A

germinal center

31
Q

name the iso type with the following
Th1
Th2
Th17

A

Th1 IgG
Th2 IgE
Th17 IgA

32
Q

what is Hyper IGM syndrome

A

Mutation of CD 40 L so no activation B cemm so Increase IGM and defective CMI cause NO MEMORY

33
Q

name the difference
tumor specific ag (TSA):
Tumor associated ag TAA:

A

tumor specific ag (TSA):
* unique to tumor
* cause immune resp
Tumor associated ag TAA:
* shared with normal cell type
* done cause immune

34
Q

tumore tx as self ag- tollerance of tumor is done becuase….
antigenic modulation of tumor done by …

A

no co stimulation

eating ag

35
Q

what are TILS tumor infilrating lyphocytes and
lyphokines activated killer LAKS

A

both are adoptive immunity to help cancer pt. lyphocytes are removed and tx with IL2

36
Q

what does rIFN alpha do

A

Increase MHC molecules and activate macrophage and NK

37
Q

what is conjugated Ab tx
& unconjugated?

A

conjugated target delivery of toxins or drug to tumor with specific AG

unconjugated: compliment based naked ab against tumor

38
Q

how do you turn a tumor cell into apc

A

make it exp by

39
Q

most common lymphoma type ?
markers?
non hodgkin or hodgkin

A

B cell
Cd19 cd20

40
Q

Follicular lymphoma
* type?
* pain?
* gene?
* fast or slow progression
* age of pt

A

Follicular lymphoma
* type - b cell
* pain -no pain
* gene - BCL2 gene over expressed (anti apoptotic gene)
* fast or slow progression: slow
* age is middle years

41
Q

Diffuse large B cell lymphoma
* type?
* location?
* fast or slow progression
* age of pt

A
  • type? b cell non hodgkin
  • location : tonsils throught orbit waldeyes ring, CNS in HIV
  • fast or slow progression: fast
  • age of pt around 60
  • CNS in HIV patiens
42
Q

Burkitt lyphoma
* marker?
* microscopic view?
* fast or slow progression
* age of pt
* what virus associated with this
* translocation of

A

Burkitt lyphoma
* marker? cd 19 20
* microscopic view? stary sky
* fast or slow progression: aggressive
* age of pt children
* virus: EBV in african involving the maxilla and non ebv in abdominal organs in adults
* translocation of 8:14 with MRC activated

43
Q

Mantel cell
* what type of lyphoma
* px?
* age of pt

A

Mantel cell
* what type of lyphoma: B cell
* px? poor prognosis
* 50 MALES

44
Q

what dz is associated with MALToma

A
  • infection and inflamation
  • sjogrens and heliovacter pylori
  • can be fixed
45
Q

Mycosis funguicides
* cell type of lyphoma
* name phases

A
  • cell type of lyphoma Th cd4+ Sezary cells
  • name phases
  • resembles fungal infection
46
Q

Adult T cell Luekemia is caused by ____ virus that makes ____ neoplams

A

Adult T cell Luekemia is caused by __ HTLV1__ virus that makes __ CD4 Th__ neoplams

47
Q

what virus causes extranodal NK t cell lyphoma

A

EBV causeing necrotizing neoplasm

48
Q

Mutiple myeloma
* shows what in the blood?
* what tests?
* sx

A
  • punched out bone
  • agressive
  • shows what in the blood? stacks of rbc , russle boddies
  • what tests? emce jones protein causes renal damage
  • bone pain and hyper calcemia
49
Q

What neoplams is associated with hyperviscosity
agressive?

A

waldenstrom moderatly agressive
IGM monoclonal

50
Q

what is the most agressive lymphoma

A

diffuse large B cell

51
Q

orbit lymphoma most likely

A

diffuse

52
Q

what is nodular sclerosis
px? and age

A

most common form of hodgkin
-young
-good px

53
Q

dz associated with hodgkins lyphoma

A

HIV EBV

54
Q

Waldeye ring involved in nonhodgkin or hodgkin

A

non hodgkin

55
Q

what is it associated with ..
* primary AL is primary amyloidosis ,
* secondary SAA

A

AL - multiple myoloma, enlarged tongue
SAA - prolonged inflammation like RA

BASIG q1 (11 decks)

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