Exam 6 Flashcards
what is this and what does it show CD19 20 positive or negative
reed sternberg cell shows hodgkins lymphoma
negative
what is this and what does it show
russel bodies in plasma cells - shows plasma cell neoplasm dyscrasis multiple myeloma
- monoclonal gamma globulin
Th1
-cell surface glyco proteins
-secretions
cell surface glyco proteins: CD4 and TCR
-secretions: Interluekin 2
IFN gama
Th2
-cell surface glyco proteins
-secretions
cell surface glyco proteins: CD4 and TCR
-secretions: Interluekin 4
&5
Tc
-cell surface glyco proteins
-secretions
cell surface glyco proteins: CD8 CD95L TCR
-secretions: Perforin Granzyme
Tr
-cell surface glyco proteins
-secretions
cell surface glyco proteins: CD4 CD25 TCR
-secretions: Inter luekin 10
Somatic Recombination occurs on the alpha chain of the TCR and at what stage (pro, pre, immature, mature)
Somatic Recombination occurs on the beta chain of the TCR and at what stage (pro, pre, immature, mature)
what cell is double positive (pro, pre, immature, mature)
alpha chain in the pre T
beta chain in the pro T
immature
mature cells hace what CD
CD 4 or CD 8
what binds to CTLA-4 and what does it do when it bind
CTLA-4 on the t cell binds to B7 to stop proliferation
what binds to cd28
CD28 is on T cell and it binds to B7 on the APC cell to cause proliferation
Explain the activation/ maturation of T cells
Cancer pt are given ____ to make agressive T cell
IL 2
inhibiting NFAT does what
causes immuno supression no proliferation activation of T cells —- cyclosporins
what starts proliferation of T cells … aka what binds to start proliferation
IL 2
what causes the cell to produce cyclins
IL 2 to IL2 receptors
after proliferation what two types of t cells are produced (which are shorter lived)
effector (shorter lived)
memory T (long lived)
draw types of effector Helper cells and what they secrete
what cells have FAS receptor and what cell hav FASL
all nucleated cells have FAS
CTL cd8 + bind to it
what is released if macrophage cant digest something and what does this activake
IL 12
activate NK cells
what is the first line of defense in viruses,
what does this cause
innate or adaptive
inhibition of intfection by releasing INF-a IFN-B
* antiviral mech
* increase MHC 1exp
* stimulate NK
innate
what activates NK
-INF beta and alpha
-IL12
-IL 15
sti
Central memory and effector memory difference
central
* secondary lymph tissue
* proliferate quick
Effector
* peripheral
* cecrete cytokines
* DONT PROLIFERATE
which cells express CD19
which cells express heavy chain and surrogate
proB cells which is the eliest
pre- b
where does positive selection occur for B cells
periphery
what is anergic and what cells become this
unresponsive cells thtat show low levels of IgM
b cells with weak interaction to cell antigen
what cells become clonally ignorant
self reactive but done respond have ig D and IGM
what needs to bind so that way B cells activate
ag to BCR
(Th2)TCR to MHC 2
(Th2) CD40L to CD40
what cells show CD21
mature B cells
what is peripheral tolerance
mechanisms to get rid of self reactive lymphocytes
where does affinity maturation occur of b cell
germinal center
name the iso type with the following
Th1
Th2
Th17
Th1 IgG
Th2 IgE
Th17 IgA
what is Hyper IGM syndrome
Mutation of CD 40 L so no activation B cemm so Increase IGM and defective CMI cause NO MEMORY
name the difference
tumor specific ag (TSA):
Tumor associated ag TAA:
tumor specific ag (TSA):
* unique to tumor
* cause immune resp
Tumor associated ag TAA:
* shared with normal cell type
* done cause immune
tumore tx as self ag- tollerance of tumor is done becuase….
antigenic modulation of tumor done by …
no co stimulation
eating ag
what are TILS tumor infilrating lyphocytes and
lyphokines activated killer LAKS
both are adoptive immunity to help cancer pt. lyphocytes are removed and tx with IL2
what does rIFN alpha do
Increase MHC molecules and activate macrophage and NK
what is conjugated Ab tx
& unconjugated?
conjugated target delivery of toxins or drug to tumor with specific AG
unconjugated: compliment based naked ab against tumor
how do you turn a tumor cell into apc
make it exp by
most common lymphoma type ?
markers?
non hodgkin or hodgkin
B cell
Cd19 cd20
Follicular lymphoma
* type?
* pain?
* gene?
* fast or slow progression
* age of pt
Follicular lymphoma
* type - b cell
* pain -no pain
* gene - BCL2 gene over expressed (anti apoptotic gene)
* fast or slow progression: slow
* age is middle years
Diffuse large B cell lymphoma
* type?
* location?
* fast or slow progression
* age of pt
- type? b cell non hodgkin
- location : tonsils throught orbit waldeyes ring, CNS in HIV
- fast or slow progression: fast
- age of pt around 60
- CNS in HIV patiens
Burkitt lyphoma
* marker?
* microscopic view?
* fast or slow progression
* age of pt
* what virus associated with this
* translocation of
Burkitt lyphoma
* marker? cd 19 20
* microscopic view? stary sky
* fast or slow progression: aggressive
* age of pt children
* virus: EBV in african involving the maxilla and non ebv in abdominal organs in adults
* translocation of 8:14 with MRC activated
Mantel cell
* what type of lyphoma
* px?
* age of pt
Mantel cell
* what type of lyphoma: B cell
* px? poor prognosis
* 50 MALES
what dz is associated with MALToma
- infection and inflamation
- sjogrens and heliovacter pylori
- can be fixed
Mycosis funguicides
* cell type of lyphoma
* name phases
- cell type of lyphoma Th cd4+ Sezary cells
- name phases
- resembles fungal infection
Adult T cell Luekemia is caused by ____ virus that makes ____ neoplams
Adult T cell Luekemia is caused by __ HTLV1__ virus that makes __ CD4 Th__ neoplams
what virus causes extranodal NK t cell lyphoma
EBV causeing necrotizing neoplasm
Mutiple myeloma
* shows what in the blood?
* what tests?
* sx
- punched out bone
- agressive
- shows what in the blood? stacks of rbc , russle boddies
- what tests? emce jones protein causes renal damage
- bone pain and hyper calcemia
What neoplams is associated with hyperviscosity
agressive?
waldenstrom moderatly agressive
IGM monoclonal
what is the most agressive lymphoma
diffuse large B cell
orbit lymphoma most likely
diffuse
what is nodular sclerosis
px? and age
most common form of hodgkin
-young
-good px
dz associated with hodgkins lyphoma
HIV EBV
Waldeye ring involved in nonhodgkin or hodgkin
non hodgkin
what is it associated with ..
* primary AL is primary amyloidosis ,
* secondary SAA
AL - multiple myoloma, enlarged tongue
SAA - prolonged inflammation like RA
