Exam 3 Flashcards
Basal lamina made of what and what type of collagen
Epithelial
4
Reticular lamina made from what and what type of collagen
CT type 3
Name the colors
Blue reticular lamina
Yellow basal lamina
Green epithelial lamina
ecm consist of
ground substance and fibers
ground substance contains what and what kind of charg
gags proteoglycans PGs and multi adhesive glycoproteins , negative blue on h& e
to stain ground substance what dye would you use and why
carbon rich so PAS or H & E blue cause negative charged
is fibers or ground substance for resisting compression
ground sub
S that wispy substance
Ground
What are the main things that make up CT
ECM and cells
What’s the solid and dotted line
Solid is elastic fiber dotted is collagen fiber
Fiber or fibril, which can be seen with TEM or and LM
Fiber is TEM and LM fibril is TEM only
Reticular lamina is made by
CT
Basal lamina is made by
Epithelium
Which tissue type and name forms a cross link fence shape
4 basal lamina
Hat is type 1 and 2 collagen types
1 is bone and tendon 2 is cartilage
What type forms triple helix bundle
Type 3
T E M label
T fibrils M fibrillin Eelastin
What is Marfan syndrome
Genetic disorder defective fribilin stretch marks hypermobil joints tall aortic aneurysms
Is wandering or fixed short lived
Wandering
What does the fibroblast do
Secretes and maintains constituents of ECM
What cell is it fixed or wandering
Fibroblast
What cell is it fixed or wandering what does it do
Fixed multicellular Adipocyte
What cell is it fixed or wandering
Mast cell , allergic reaction contains granules and gag anticoagulant
What cells is this and is it fixed or wandering
Macrophage fixed
What cell and is it fixed or wandering
Macrophage fixed
What cell secretes antibodies
Plasma cells
What cell is it fixed or wandering
Wandering plasma cell secretes antibodies and have lots of rough er
What cell is it wandering or fixed
Wandering plasma cells
What cell and what does it do
Stem cell differentiates into may cells
What the of connective tissue is mesenchym
Embryonic CT
What general connective tissue is where most immune responses happen
Loose ct
What type of ct in yellow marks
Loose
Name these ct
Dense irregular and dense regular
What cell secretes leptin
White fat
What kind of tissue
Brown fat
What type of tissue and what does it do
Reticular CT forms the Strom a of organs
What cell promotes growth
Mesenchym
Buffy coat has what cell
Luekocytes and platelets
What cells from blood make up exam
Plasma
What has the second least amount in the blood, plasma , Buffy , hematocrit
Hematocrit 45%
What can we sample to monitor tissue health
Plasma
What is the difference between plasma and serum
Plasma has coagulation and serum does not
List from least to most amount in blood: Platelets, erythrocytes, luekocytes
Luekocytes platelets and erythrocytes
What is polycythemia
Increase in RBc cells
What is Luekocytosis
Increase in WBC
What are the formed elements
The Buffy coat (platelets and luekocytes) and hematocrit
What organs remove dead rbc
Spleen and liver
Name the outer and inner of cell. What is the cell
Thrombocyte out hyalomere inner is granulomere
What is a halo mere and what is it made of
Microtubles out of platelet or thrombocyt
What is this cell
Thrombocyte
What happens first degranulates of platelets or platelet aggregation
Degranulates
Cell and function name granules
Neutrophil infection
Cell and its function
Eosinophil worms and paracites
Name cell and granules
Red arrow and yellow arrow is specific gran and purple arrow is azurophilic granules top cells is neutrophil bottoms is eosinophil
Cell and name granule
Yellow is specific granule for basophils
What cell and what does it do
Lymphocyte self recognition
What is a monocyte and what does it doe and look like
Fat chapped c phagocytosis
What are the yellow and red arrows
Yellow is hemopoeitic cord
Red is sinusoidal capillary
Common myeloid spits into what
Colony forming units and then blasts and then mature cells
Name each and which one had heterochromatin
Poly chromatic orthochromatic reticulocyte
- Myoblast
- Metamyoblast
3.band or stab cell
Top is neutrophil bottom is eosinophil
Nuetrophil eosinophil basophil name their specific granules
Nuetrophil: and-h oxidase lysozyme
Eosinophil : crystalloid body
Basophil: heparin histamine
Name from top left to right
Orthocromatic , polychromatic , basophillic eythroblast , reticulocyte
What is hemostasis
Physiological injured vessel
What is thrombosis
Pathological non injured like heart attack
What is epistaxis
Nose bleed
What is hemoptysis
Coughing up blood
What is hematamesisi
Vomiting blood
Hematochezia
Blood in stool
Hematuria
Blood in ruin
What is von willebrand factor
For primary platelet plug
Is primary or secondary cause epistaxis and bleeding of gums
Primary
Primary hemostasis issue caused by what
Thrombocytopenia (low platelets) ; vit c deficiency
What is ADP thrombin A2 or TXA2
Secreted for primary hemostasis for clothing
GPllB-IIIa bind to what
Fibrinogen
How does aspirin work
It prevents production of TXA2
How does placid work
ADP receptor blocker
If you inhibit GPII- III a what happens
You make a blood thinner
What lab tests to assoc primary hemostasis I
CBS , platlete function , von willabrand function, vitamin c test
Explain secondary hemostasis
Factor 3 activated factor 7. 7 activates thrombin to convert fibrinogen to fibrin soluble And then factor 13 cross link to stabilize fibrin
What factors need ca and K to coagulate
2 7 9 10
What is proteins C and S
ANTI coag need K and Ca
what activated factor 13
Thrombin
How does Coumadin and warfarin work
K antagonist
Explain fibrinolysis
What is urokinase … what is strepto kinase
Plasminogen thatat fibrin lyses created by bacteria
What does PTT and PT test for
PT is extrinsic factors 7 10 5 von prothrombin willebrand dz fibrogen… ptt is intrinsic 5,8, 9, 10,11,12
What factors if vit k deficient pt or ptt prolong
2 7 9 10 , pt prolong
Hemophilia is what kind of genetic disorder what pt or ptt prolong what factor causes
Ptt prolong x recessive 8
What is ATIII
Natural coagulant
What is heparin
Natural coag
Where do thrombi formed in the veins go
Right heart to the lungs
Where do thrombi formed in the arterial go
Systemic
What is virchows triad
Endothelial injury
Abnormal blood flow
Hypercoagulability
What cause intact vessel blood clot
Virchows triad . Injured endothelial , abn blood flow, hyper coag
What factor comes with genetic hyper coag
5
Leiden dz
Factor 5 missence , causes resistance to 2 digestion of protein c ,causes dot
What is antiphospholipid syndrome
Auto immune causes stroke MI
How does covid coag work
Increase in d dimer
Lines of zhan
Caused by alt platelets no fibrin shows thrombosisi
What is a mural thrombus and why is it so important
Common reason for system emboli. Thrombus in the heart changer
What is phlebothrobosis
Vein clot
What test for dot
D dimmer
What is thrombophlebitis
Embolus that comes off blood clot
Dot causes what
P[ulmonary embolism saddle embolus (block pulmonary art)
What is atheroemboli
Spontaneous from ulcerated plaques following angioplasty, can happen to retina
What can occur after Angie pasty
Atheroemboli
Embolus in retina
CRAO
Exogenous air vs endogenous air
Exogenous is for obstetrics and pneumonia thorax, endogenous is secondary to subadivers
What organs do white anemic infarctions
Kidney heart and spleen
Organs for hemorrhagic infarcts
Intestines and lungs
Patience with thrombocytopenia are at risk for
Bleeding
Facto v Leiden induces
Hypercoagulable state